Category: Interviews
A Sarcopenia-Related MicroRNA May Help Pinpoint Its Origin
November 17, 2025
In Aging Cell, researchers have discovered a potential way to use a microRNA to diagnose sarcopenia, the age-related loss of muscle. Primary and secondary sarcopenia Previous research has been able
NAD+ Rescues Mouse Tauopathy by Fixing Alternative Splicing
November 14, 2025
A new study reveals a surprising mechanism that might be behind the beneficial effects of NAD+ in preclinical models of Alzheimer’s [1]. Which way to splice it? Not every part
The Key Questions of Longevity Research
November 13, 2025
In GeroScience, a large team of researchers, including João Pedro de Magalhães, has described a hundred currently unsolved problems in the field. Finding the right questions Understanding the fundamental nature
If Death Were Optional, Would You Still Choose It?
November 12, 2025
The idea of living longer, healthier lives thanks to rejuvenation biotechnology has steadily become more common. Gradually increasing numbers of articles are discussing this idea, especially as science is starting
Multilingualism Is Associated With Delayed Aging
November 12, 2025
A recent study of over 80,000 Europeans concluded that speaking more than one language is associated with delayed aging. Further analysis suggested that the protective effect of speaking one foreign
New Gene Therapy Robustly Lowers LDL and Triglycerides
November 11, 2025
A new Phase 1 trial produced encouraging safety and efficacy results for a CRISPR-based gene therapy that silences a gene important for lipid regulation. This therapy might increase adherence and
High-Fiber Foods May Fight T Cell Senescence
November 10, 2025
Researchers have discovered that butyrate, a short-chain fatty acid with well-documented gut benefits, fights senescence in T cells. Immune senescence drives inflammaging Senescence of the immune system (immunosenescence) is a
Mice With Reduced Astrocytic Oxidative Stress Live Longer
November 7, 2025
Scientists have discovered that directly reducing the production of reactive oxygen species (ROS) at their source in astrocytes, mitochondrial complex III, improves neuronal health and significantly increases lifespan in a
Insilico Unveils Portfolio of Unique Cardiometabolic Assets
November 7, 2025
Nov 7, 2025 – Insilico Medicine (“Insilico”), a clinical-stage generative artificial intelligence (AI)-driven drug discovery and development company, today announced the launch of its innovative cardiometabolic disease portfolio of unique
EDA2R May Be an Aging Biomarker and Inflammaging Target
November 6, 2025
A review in Aging Cell has cataloged the harmful effects of EDA2R, a protein that affects three distinct inflammation-related pathways. A necessary protein gone bad Like nearly every other protein
Rapamycin May Delay Age-Related Fertility Decline
November 5, 2025
In a recent study, researchers identified that an increase in the expression of ribosome-related genes and a loss of protein homeostasis contribute to the age-related decline in female fertility. Rapamycin
Skin Aging Underlined by Loss of Capillary Macrophages
November 4, 2025
A new study ties the disappearance of capillary-associated macrophages to age-related vascular degeneration in the skin. Boosting their function with a growth factor offers a possible avenue for anti-aging interventions
Rejuvenation Roundup October 2025
November 3, 2025
The trick-or-treaters have all gone home as the leaves have fallen to the ground, but rejuvenation biotech attempts to prevent human beings from fading away. Here’s what’s been done to
Men Might Need More Exercise to Lower Cardiovascular Risks
October 31, 2025
A new observational study suggests that men need more than twice as much exercise as women do to achieve the same level of reduction in the risk of cardiovascular heart
Maintenance Stays Efficient in Healthy Older People’s Cells
October 30, 2025
Researchers publishing in Aging Cell have found that the efficiency of autophagy, a cellular maintenance process, increases rather than decreases in some T cells derived from healthy older people. Keeping
A Sarcopenia-Related MicroRNA May Help Pinpoint Its Origin
November 17, 2025
In Aging Cell, researchers have discovered a potential way to use a microRNA to diagnose sarcopenia, the age-related loss of muscle. Primary and secondary sarcopenia Previous research has been able to distinguish sarcopenia by its sources. Primary sarcopenia directly comes from the processes of aging, while secondary sarcopenia is a
NAD+ Rescues Mouse Tauopathy by Fixing Alternative Splicing
November 14, 2025
A new study reveals a surprising mechanism that might be behind the beneficial effects of NAD+ in preclinical models of Alzheimer’s [1]. Which way to splice it? Not every part of a DNA sequence gets translated into a protein. Each sequence consists of exons, which are included in the final
The Key Questions of Longevity Research
November 13, 2025
In GeroScience, a large team of researchers, including João Pedro de Magalhães, has described a hundred currently unsolved problems in the field. Finding the right questions Understanding the fundamental nature of aging has been a problem since people first endeavored to live longer, to the point that finding the right
If Death Were Optional, Would You Still Choose It?
November 12, 2025
The idea of living longer, healthier lives thanks to rejuvenation biotechnology has steadily become more common. Gradually increasing numbers of articles are discussing this idea, especially as science is starting to catch up and may eventually even deliver on it. With that in mind, I was pleasantly surprised this week
Multilingualism Is Associated With Delayed Aging
November 12, 2025
A recent study of over 80,000 Europeans concluded that speaking more than one language is associated with delayed aging. Further analysis suggested that the protective effect of speaking one foreign language diminished with age, while the protective effect of speaking two or more foreign languages was more robust with aging
New Gene Therapy Robustly Lowers LDL and Triglycerides
November 11, 2025
A new Phase 1 trial produced encouraging safety and efficacy results for a CRISPR-based gene therapy that silences a gene important for lipid regulation. This therapy might increase adherence and reduce side effects [1]. Addressing the adherence problem High levels of LDL cholesterol (LDL-C) and triglycerides are a major risk
High-Fiber Foods May Fight T Cell Senescence
November 10, 2025
Researchers have discovered that butyrate, a short-chain fatty acid with well-documented gut benefits, fights senescence in T cells. Immune senescence drives inflammaging Senescence of the immune system (immunosenescence) is a problem that drives many others. In particular, T cells are known to secrete inflammatory SASP compounds [1] and drive the
Mice With Reduced Astrocytic Oxidative Stress Live Longer
November 7, 2025
Scientists have discovered that directly reducing the production of reactive oxygen species (ROS) at their source in astrocytes, mitochondrial complex III, improves neuronal health and significantly increases lifespan in a mouse model of Alzheimer’s [1]. Dangerous species Reactive oxygen species (ROS) are short-lived, highly reactive oxygen-containing molecules such as superoxide
Insilico Unveils Portfolio of Unique Cardiometabolic Assets
November 7, 2025
Nov 7, 2025 – Insilico Medicine (“Insilico”), a clinical-stage generative artificial intelligence (AI)-driven drug discovery and development company, today announced the launch of its innovative cardiometabolic disease portfolio of unique highly-differentiated molecules discovered using generative AI. Powered by Insilico’s proprietary end-to-end Pharma.AI platform, the portfolio covers a range of diverse
EDA2R May Be an Aging Biomarker and Inflammaging Target
November 6, 2025
A review in Aging Cell has cataloged the harmful effects of EDA2R, a protein that affects three distinct inflammation-related pathways. A necessary protein gone bad Like nearly every other protein with documented harmful effects, this one is required for certain systems to function properly. The EDA gene is needed for
Rapamycin May Delay Age-Related Fertility Decline
November 5, 2025
In a recent study, researchers identified that an increase in the expression of ribosome-related genes and a loss of protein homeostasis contribute to the age-related decline in female fertility. Rapamycin restored this balance and increased fertility rates in a human trial [1]. The first system to age The loss of
Skin Aging Underlined by Loss of Capillary Macrophages
November 4, 2025
A new study ties the disappearance of capillary-associated macrophages to age-related vascular degeneration in the skin. Boosting their function with a growth factor offers a possible avenue for anti-aging interventions [1]. Macrophages, capillaries, and skin aging Skin aging might not be the most dangerous aspect of aging, but it certainly
Rejuvenation Roundup October 2025
November 3, 2025
The trick-or-treaters have all gone home as the leaves have fallen to the ground, but rejuvenation biotech attempts to prevent human beings from fading away. Here’s what’s been done to fight aging in October. Team and activities Our Campaign for Public Longevity: Public trust is the breakthrough that unlocks all
Men Might Need More Exercise to Lower Cardiovascular Risks
October 31, 2025
A new observational study suggests that men need more than twice as much exercise as women do to achieve the same level of reduction in the risk of cardiovascular heart disease [1]. Understanding sex differences In recent years, scientists have questioned how much exercise is needed for tangible health benefits.
Maintenance Stays Efficient in Healthy Older People’s Cells
October 30, 2025
Researchers publishing in Aging Cell have found that the efficiency of autophagy, a cellular maintenance process, increases rather than decreases in some T cells derived from healthy older people. Keeping cells healthy The researchers introduce their paper by discussing autophagy and its decline in aging. They focus specifically on its