Category: News
Transient Epigenetic Rejuvenation Recorded in Athletes
August 22, 2025
A new study has found that professional soccer players experience a drop in their biological age after a match, as measured by biomarkers assessed with state-of-the-art methylation clocks [1]. We
Researchers Identify a Key Senescence-Spreading Factor
August 21, 2025
In Metabolism Clinical & Experimental, researchers have described how the reduced isoform of the SASP factor HMGB1 causes senescence to spread. An alarm that doesn’t turn off HMGB1 is an
Low-Dose Lithium Reverses Features of Alzheimer’s in Mice
August 20, 2025
In a recent study, researchers identified the critical role that lithium plays in brain health and the development of mild cognitive impairment and Alzheimer’s disease. Supplementing with a lithium salt
An Overly Youthful Immune System Might Cause Autoimmunity
August 19, 2025
Scientists have proposed a hypothesis that immune aging might be necessary to shield people from autoimmune effects, as the repertoire of autoantigens expands with age [1]. A double-edged sword? The
Exosomes Reduce Sarcopenia in a Mouse Model
August 18, 2025
Researchers have discovered that exosomes secreted by mesenchymal stem cells derived from human umbilical cord tissue (hucMSC-Exos) restore muscle function in a mouse model of sarcopenia. Useful messengers Exosomes are
Moving to a More Walkable City Increases Step Count
August 15, 2025
Working with data from a smartphone app, scientists have shown for the first time that relocating to a more walkable city is linked to increased daily step counts [1]. Most
How Inflammation Is Linked to Heart Disease
August 14, 2025
In Cell Reports Medicine, researchers have published a detailed review on the relationship between cardiovascular disease and the age-related inflammation known as inflammaging. The immune system itself ages Inflammaging occurs
Cannabis as a Treatment for Age-Related Diseases
August 13, 2025
Researchers have recently published a review on how cannabis use among older adults impacts age-related conditions and longevity [1]. Cannabinoids and longevity In recent years, researchers have observed an increase
Nir Barzilai: “Positive Evidence for Metformin is Mounting”
August 12, 2025
Dr. Nir Barzilai, the director of the Institute for Aging Research at the Albert Einstein College of Medicine, among his many other titles, is one of geroscience’s most prominent figures.
How FGF21 Fights Back Against a Muscle-Wasting Disease
August 11, 2025
In Aging, researchers have reported on how an increase in FGF21, a myokine that encourages muscle growth, impacts the progression of amyotrophic lateral sclerosis (ALS). Progressive and fatal ALS is
Mitochondria Transplant Improves Chemotherapy in Lung Cancer
August 8, 2025
Scientists have demonstrated that injecting healthy mitochondria either systematically or directly into the tumor microenvironment boosts the efficiency of a standard anti-cancer therapy [1]. Mitochondria’s dual role in lung cancer
Lifespan Alliance Launch & New Leadership at LRI
August 7, 2025
Mountain View, California — Lifespan Research Institute, a nonprofit leader in longevity science and advocacy, announces the launch of the Lifespan Alliance, a sponsorship initiative uniting mission-driven companies and visionary
A Better Extracellular Matrix Makes Aged Cells Act Youthful
August 7, 2025
Researchers have found that growing older cells in a youthful medium causes them to behave and function more like younger cells, suggesting a new method of creating stem cell-based therapies.
Nicotine Consumption Improves Motor Functions in Male Mice
August 6, 2025
A recent study reported that long-term nicotine consumption had a positive impact on motor function in male mice. The beneficial effects were mediated by sphingolipid and NAD+ metabolism [1]. Two
Study Paves Road for Oral Delivery of Proteins
August 5, 2025
Using a pathogen-originated protein and a human antibody, scientists have created a chimeric construct that can deliver protein cargo via the intestine. This technology could potentially replace cumbersome injections [1].
Transient Epigenetic Rejuvenation Recorded in Athletes
August 22, 2025
A new study has found that professional soccer players experience a drop in their biological age after a match, as measured by biomarkers assessed with state-of-the-art methylation clocks [1]. We asked Dr. Steve Horvath, the study’s co-author, to comment. Clocks, stress, and exercise Epigenetic clocks have
Researchers Identify a Key Senescence-Spreading Factor
August 21, 2025
In Metabolism Clinical & Experimental, researchers have described how the reduced isoform of the SASP factor HMGB1 causes senescence to spread. An alarm that doesn’t turn off HMGB1 is an alarmin protein, which, as its name suggests, is released as a response to damage, making it
Low-Dose Lithium Reverses Features of Alzheimer’s in Mice
August 20, 2025
In a recent study, researchers identified the critical role that lithium plays in brain health and the development of mild cognitive impairment and Alzheimer’s disease. Supplementing with a lithium salt called lithium orotate can reverse many of its cognitive decline-related changes on the molecular and cellular
An Overly Youthful Immune System Might Cause Autoimmunity
August 19, 2025
Scientists have proposed a hypothesis that immune aging might be necessary to shield people from autoimmune effects, as the repertoire of autoantigens expands with age [1]. A double-edged sword? The decline of the immune system is a major driver of aging, making us more susceptible to
Exosomes Reduce Sarcopenia in a Mouse Model
August 18, 2025
Researchers have discovered that exosomes secreted by mesenchymal stem cells derived from human umbilical cord tissue (hucMSC-Exos) restore muscle function in a mouse model of sarcopenia. Useful messengers Exosomes are vesicles that carry molecular messages from cell to cell. When derived from youthful sources, they have
Moving to a More Walkable City Increases Step Count
August 15, 2025
Working with data from a smartphone app, scientists have shown for the first time that relocating to a more walkable city is linked to increased daily step counts [1]. Most of the increase consists of moderate-to-vigorous physical activity (MVPA), which is particularly healthy. A natural experiment
How Inflammation Is Linked to Heart Disease
August 14, 2025
In Cell Reports Medicine, researchers have published a detailed review on the relationship between cardiovascular disease and the age-related inflammation known as inflammaging. The immune system itself ages Inflammaging occurs in both the cells sending out signals and in the cells receiving them. The numbers of
Cannabis as a Treatment for Age-Related Diseases
August 13, 2025
Researchers have recently published a review on how cannabis use among older adults impacts age-related conditions and longevity [1]. Cannabinoids and longevity In recent years, researchers have observed an increase in cannabis use among older adults, mostly for chronic conditions, such as arthritis, pain, sleep improvement,
Nir Barzilai: “Positive Evidence for Metformin is Mounting”
August 12, 2025
Dr. Nir Barzilai, the director of the Institute for Aging Research at the Albert Einstein College of Medicine, among his many other titles, is one of geroscience’s most prominent figures. He is everywhere all at once, seemingly collaborating with the entire world, but is best known
How FGF21 Fights Back Against a Muscle-Wasting Disease
August 11, 2025
In Aging, researchers have reported on how an increase in FGF21, a myokine that encourages muscle growth, impacts the progression of amyotrophic lateral sclerosis (ALS). Progressive and fatal ALS is an age-related disease that is characterized by the degeneration of motor neurons throughout the spinal cord
Mitochondria Transplant Improves Chemotherapy in Lung Cancer
August 8, 2025
Scientists have demonstrated that injecting healthy mitochondria either systematically or directly into the tumor microenvironment boosts the efficiency of a standard anti-cancer therapy [1]. Mitochondria’s dual role in lung cancer While not the most prevalent type of cancer, lung cancer causes more deaths than any other.
Lifespan Alliance Launch & New Leadership at LRI
August 7, 2025
Mountain View, California — Lifespan Research Institute, a nonprofit leader in longevity science and advocacy, announces the launch of the Lifespan Alliance, a sponsorship initiative uniting mission-driven companies and visionary organizations dedicated to extending healthy human lifespan. Member organizations, including launch sponsors AgingBiotech.info, Immortal Dragons, Rejuve.bio,
A Better Extracellular Matrix Makes Aged Cells Act Youthful
August 7, 2025
Researchers have found that growing older cells in a youthful medium causes them to behave and function more like younger cells, suggesting a new method of creating stem cell-based therapies. Cultivating patient-derived cells For some time, mesenchymal stem cells (MSCs), which can be used to differentiate
Nicotine Consumption Improves Motor Functions in Male Mice
August 6, 2025
A recent study reported that long-term nicotine consumption had a positive impact on motor function in male mice. The beneficial effects were mediated by sphingolipid and NAD+ metabolism [1]. Two faces of tobacco smoking Smoking tobacco is widely considered detrimental to health for multiple good reasons,
Study Paves Road for Oral Delivery of Proteins
August 5, 2025
Using a pathogen-originated protein and a human antibody, scientists have created a chimeric construct that can deliver protein cargo via the intestine. This technology could potentially replace cumbersome injections [1]. Getting rid of the needle Protein-based treatments are very powerful, but they cannot yet be administered