Category: News
A Brain Clock for Finding Rejuvenating Medications
August 4, 2025
Researchers have developed a transcription-based clock that estimates brain age and used it to identify potential interventions against age-related neurodegeneration. Deciding which -omic to use While neurodegeneration and brain aging
Study Finds Metformin’s Action Is Regulated by the Brain
August 1, 2025
A new study has shown that, unlike many other glucose-lowering drugs, metformin is regulated by the protein Ras1 in a specific subset of neurons, and when injected into the brain,
Rejuvenation Roundup July 2025
August 1, 2025
Summer is heating things up, both in the Northern Hemisphere and in the world of rejuvenation biotechnology. Here’s what’s happened in July. Team and activities The 2025 Longevity Summit Dublin:
Senescent Cells, Osteoporosis, and Alzheimer’s Are Linked
July 31, 2025
Researchers publishing in Nature Aging have discovered how Alzheimer’s-related protein aggregates are also related to senescent cells and osteoporosis. Beyond the brain The amyloid tangles that result from a loss
Rejuvenating Muscles in Mice With Senomorphic Treatment
July 30, 2025
A recent study investigated senescence in mouse and human skeletal muscle tissue. The authors demonstrated that the antiviral drug maraviroc reduces senescence and improves muscle health in aged mice [1].
The Tale of One Tower: SF-Based Vertical Longevity Village
July 29, 2025
In downtown San Francisco, an entire tower is becoming a hub for longevity, AI, crypto, and robotics. It just hosted its first longevity conference. How does a group conquer a
Fighting Osteoarthritis by Targeting Fatty Acids
July 28, 2025
In the Cell journal iScience, researchers have published their discovery of a protein that inhibits osteoarthritis in mice by diminishing fatty acid production. Fats in the wrong place Previous work
7,000 Steps a Day Are Enough for Most Benefits
July 25, 2025
A massive new meta-analysis confirms that 10,000 daily steps are not required for most of the health benefits of walking. Around 7,000 seems to be the sweet spot [1]. A
A Gene That Keeps Cells Under Control
July 24, 2025
Researchers publishing in Cell Stem Cell have investigated the function of the gene DNMT3A and found that it has wide-ranging effects beyond methylation. More effects than expected Clonal hematopoiesis (CH),
Organ-Specific Aging Analysis Reveals Disease Connections
July 23, 2025
A recent study explored the differences in the speed of organ aging. The researchers have built models that can predict the odds of diseases and mortality risk based on organ-specific
FDA-Approved Drug Combo Rescues Alzheimer’s in Mice
July 22, 2025
Scientists have creatively used large databases of existing FDA-approved drugs and electronic medical records to locate candidates that are potentially effective against Alzheimer’s [1]. New approaches needed Many previously discovered
Vesicles From Antler Cells Restore Bone in Monkeys
July 21, 2025
Researchers publishing in Nature Aging have discovered that extracellular vesicles (EVs) derived from antler blastema progenitor cells (ABPCs) restore bone mass to rhesus macaques. Finding the most effective EVs In
AI Reveals a Hidden Effect in a Failed Alzheimer’s Trial
July 18, 2025
Scientists have created an AI model that stratifies Alzheimer’s patients into subgroups that progress slowly or rapidly. When applied to a real-world failed trial, it revealed a robust effect in
Engineered Stem Cells Reduce Lung Fibrosis in Mice
July 17, 2025
In Molecular Therapy, researchers have described their creation of cells that express the regenerative factor GDF11 and found that they ameliorate fibrosis in a mouse model. Context-dependent benefits Like sirtuins
A Hallucinogenic Mushroom Compound Extends Mouse Lifespan
July 16, 2025
Researchers investigated psilocybin, a psychedelic compound found in hallucinogenic mushrooms, for its anti-aging properties. They found that it extends cellular and organismal lifespan, even when administered later in life [1].
A Brain Clock for Finding Rejuvenating Medications
August 4, 2025
Researchers have developed a transcription-based clock that estimates brain age and used it to identify potential interventions against age-related neurodegeneration. Deciding which -omic to use While neurodegeneration and brain aging are not precisely the same [1], the two are tightly linked [2]. Substantial previous work has
Study Finds Metformin’s Action Is Regulated by the Brain
August 1, 2025
A new study has shown that, unlike many other glucose-lowering drugs, metformin is regulated by the protein Ras1 in a specific subset of neurons, and when injected into the brain, even tiny doses of metformin can do the job [1]. The brain connection The safe and
Rejuvenation Roundup July 2025
August 1, 2025
Summer is heating things up, both in the Northern Hemisphere and in the world of rejuvenation biotechnology. Here’s what’s happened in July. Team and activities The 2025 Longevity Summit Dublin: The 2025 Longevity Summit Dublin was held in July, and we have the highlights from the
Senescent Cells, Osteoporosis, and Alzheimer’s Are Linked
July 31, 2025
Researchers publishing in Nature Aging have discovered how Alzheimer’s-related protein aggregates are also related to senescent cells and osteoporosis. Beyond the brain The amyloid tangles that result from a loss of proteostasis are very well-known in the context of Alzheimer’s and other neurodegenerative diseases. However, amyloid
Rejuvenating Muscles in Mice With Senomorphic Treatment
July 30, 2025
A recent study investigated senescence in mouse and human skeletal muscle tissue. The authors demonstrated that the antiviral drug maraviroc reduces senescence and improves muscle health in aged mice [1]. Aging muscle tissue Senescent cells are one of the hallmarks of aging. One of their key
The Tale of One Tower: SF-Based Vertical Longevity Village
July 29, 2025
In downtown San Francisco, an entire tower is becoming a hub for longevity, AI, crypto, and robotics. It just hosted its first longevity conference. How does a group conquer a big city? The longevity community unites tens of thousands of researchers, founders, and enthusiasts, but this
Fighting Osteoarthritis by Targeting Fatty Acids
July 28, 2025
In the Cell journal iScience, researchers have published their discovery of a protein that inhibits osteoarthritis in mice by diminishing fatty acid production. Fats in the wrong place Previous work has found a strong link between obesity and osteoarthritis of the knee [1]. While the increased
7,000 Steps a Day Are Enough for Most Benefits
July 25, 2025
A massive new meta-analysis confirms that 10,000 daily steps are not required for most of the health benefits of walking. Around 7,000 seems to be the sweet spot [1]. A step in the right direction “10,000 steps a day” is some of the most frequently heard
A Gene That Keeps Cells Under Control
July 24, 2025
Researchers publishing in Cell Stem Cell have investigated the function of the gene DNMT3A and found that it has wide-ranging effects beyond methylation. More effects than expected Clonal hematopoiesis (CH), which occurs when stem cells create large numbers of cells with the same mutation, is linked
Organ-Specific Aging Analysis Reveals Disease Connections
July 23, 2025
A recent study explored the differences in the speed of organ aging. The researchers have built models that can predict the odds of diseases and mortality risk based on organ-specific proteins found in plasma [1]. Not all organs age equally Since each organ in the human
FDA-Approved Drug Combo Rescues Alzheimer’s in Mice
July 22, 2025
Scientists have creatively used large databases of existing FDA-approved drugs and electronic medical records to locate candidates that are potentially effective against Alzheimer’s [1]. New approaches needed Many previously discovered drugs may be effective beyond their original indications, but it is challenging to match them to
Vesicles From Antler Cells Restore Bone in Monkeys
July 21, 2025
Researchers publishing in Nature Aging have discovered that extracellular vesicles (EVs) derived from antler blastema progenitor cells (ABPCs) restore bone mass to rhesus macaques. Finding the most effective EVs In the world of rejuvenation research, EVs are nothing new. We have covered them extensively, as studies
AI Reveals a Hidden Effect in a Failed Alzheimer’s Trial
July 18, 2025
Scientists have created an AI model that stratifies Alzheimer’s patients into subgroups that progress slowly or rapidly. When applied to a real-world failed trial, it revealed a robust effect in the former subgroup [1]. Stratify and conquer Drugs don’t work for everyone equally. Unfortunately, clinical trials
Engineered Stem Cells Reduce Lung Fibrosis in Mice
July 17, 2025
In Molecular Therapy, researchers have described their creation of cells that express the regenerative factor GDF11 and found that they ameliorate fibrosis in a mouse model. Context-dependent benefits Like sirtuins and klotho, GDF11 is a biochemical factor that has been heavily investigated in the context of
A Hallucinogenic Mushroom Compound Extends Mouse Lifespan
July 16, 2025
Researchers investigated psilocybin, a psychedelic compound found in hallucinogenic mushrooms, for its anti-aging properties. They found that it extends cellular and organismal lifespan, even when administered later in life [1]. From ancient times to contemporary therapies Hallucinogenic mushrooms have a long history of use, reaching back