Category: News
A Key Protein for Tendon Health
February 17, 2025
Researchers publishing in Matrix Biology Plus have discovered that cochlin, a protein that decreases with age, is vital for the health of tendons. Tendons require a healthy extracellular matrix Previous
A Potential New Target for Normal Brain Aging
February 13, 2025
Yesterday in Aging Cell, researchers published their findings that using gene therapy to overexpress a synaptic promoter increases cognitive ability in ordinary, middle-aged mice. Hevin vs. SPARC Astrocytes are general-purpose
Probiotics Slow Down Alzheimer’s Disease in Mice
February 12, 2025
A new study dives into a human-derived probiotic cocktail meant to protect against Alzheimer’s disease. The treatment improves gut health and reduces inflammation in mice [1]. The earlier, the better
Mitochondrial Damage May Drive Type 2 Diabetes
February 11, 2025
A new study suggests that damaged mitochondria activate the integrated stress response, which causes pancreatic β-cells, as well as liver and fat cells, to lose their identity and malfunction [1].
Creating a Functional Pancreas From Human Cells
February 10, 2025
In Cell Reports Medicine, researchers have described how they created a fully functional pancreas made from human cells and found it to work in mice. A new era of organ
Some Stem Cells Remain Youthful With Age
February 6, 2025
A team of scientists has discovered that some hematopoietic stem cells (HSCs) lose their ability to differentiate into useful somatic cells and that removing those bad HSCs is beneficial. Blood
How the Yamanaka Factors Affect Female Reproduction in Rats
February 5, 2025
The authors of a recent study reported that OSKM/Yamanaka factor gene therapy in rats results in higher fertility at an older age compared to controls and allows older rats to
Early Adult Mortality Remains High in the US
February 4, 2025
Mortality among Americans aged 25-44 has risen substantially between 2011 and 2023, a new study has found, and it remains high even after having passed the COVID-related peak [1]. Riches
New Nanoparticles for Treating Arthritis
February 3, 2025
In the Journal of Nanobiotechnology, researchers have described a new method of delivering a long-lasting treatment into cartilage. A protein that promotes autophagy Previous work has linked expression of the
Rejuvenation Roundup January 2025
February 3, 2025
As rejuvenation research advances from theory to practice, more therapies start making their way into the clinic. 2025 continues with both mouse experiments and human clinical trials. Interviews Cyclarity Launches
Artificially Grown Tissue Repairs Heart Failure in Monkeys
January 31, 2025
German scientists have created lab-grown “patches” of heart muscle tissue derived from pluripotent stem cells. Following a success with rhesus monkeys, they have obtained approval for a human trial [1].
Inhibiting a Fundamental Factor in Brain Inflammation
January 30, 2025
Researchers have devised a method of reducing brain inflammation by creating a long-lasting inhibitor of the inflammatory factor NF-κB. Targeting inflammaging at its roots This study, published in the Nature
Ultrasound as a Tool to Eliminate Senescent Cells
January 29, 2025
A new study suggests that low-intensity pulsed ultrasound (LIPUS) can be beneficial in eliminating senescent cells through the recruitment and activation of immune cells [1]. The double-edged sword of the
New Database Lets You Know How Processed Your Food Is
January 28, 2025
Scientists have presented GroceryDB, an open-access online database that measures the degree of processing of tens of thousands of products sold in three major US grocery chains [1]. What is
Restoring Cellular Proliferation Through Exosomes
January 27, 2025
In Cell Metabolism, researchers have described how a microRNA (miRNA) derived from exosomes generated by human embryonic stem cells (hESCs) restores function and fights senescence in cell cultures and mice.
A Key Protein for Tendon Health
February 17, 2025
Researchers publishing in Matrix Biology Plus have discovered that cochlin, a protein that decreases with age, is vital for the health of tendons. Tendons require a healthy extracellular matrix Previous work has found that tendon tissues, which link muscle to bone, require a healthy extracellular matrix
A Potential New Target for Normal Brain Aging
February 13, 2025
Yesterday in Aging Cell, researchers published their findings that using gene therapy to overexpress a synaptic promoter increases cognitive ability in ordinary, middle-aged mice. Hevin vs. SPARC Astrocytes are general-purpose helper cells of the brain, and one of their tasks is to maintain synapse structure [1].
Probiotics Slow Down Alzheimer’s Disease in Mice
February 12, 2025
A new study dives into a human-derived probiotic cocktail meant to protect against Alzheimer’s disease. The treatment improves gut health and reduces inflammation in mice [1]. The earlier, the better Early interventions to prevent or delay Alzheimer’s disease might be a more feasible approach than reversing
Mitochondrial Damage May Drive Type 2 Diabetes
February 11, 2025
A new study suggests that damaged mitochondria activate the integrated stress response, which causes pancreatic β-cells, as well as liver and fat cells, to lose their identity and malfunction [1]. Blocking this response had benefits in mouse models. The mitochondria-diabetes connection Like with many diseases, the
Creating a Functional Pancreas From Human Cells
February 10, 2025
In Cell Reports Medicine, researchers have described how they created a fully functional pancreas made from human cells and found it to work in mice. A new era of organ replacement In their introduction, the researchers discuss the well-known problems with insulin injections to treat Type
Some Stem Cells Remain Youthful With Age
February 6, 2025
A team of scientists has discovered that some hematopoietic stem cells (HSCs) lose their ability to differentiate into useful somatic cells and that removing those bad HSCs is beneficial. Blood creation diminishes with age Hematopoiesis refers to the production of blood cells, both white and red.
How the Yamanaka Factors Affect Female Reproduction in Rats
February 5, 2025
The authors of a recent study reported that OSKM/Yamanaka factor gene therapy in rats results in higher fertility at an older age compared to controls and allows older rats to have regular cycles [1]. Rejuvenating Yamanaka factors Multiple studies have suggested that gene therapy that uses
Early Adult Mortality Remains High in the US
February 4, 2025
Mortality among Americans aged 25-44 has risen substantially between 2011 and 2023, a new study has found, and it remains high even after having passed the COVID-related peak [1]. Riches to rags Despite the US being one of the world’s richest countries, Americans’ average life expectancy
New Nanoparticles for Treating Arthritis
February 3, 2025
In the Journal of Nanobiotechnology, researchers have described a new method of delivering a long-lasting treatment into cartilage. A protein that promotes autophagy Previous work has linked expression of the FGF18 protein with healthy cartilage and joints [1]. Problems with the gene responsible for FGF18 lead
Rejuvenation Roundup January 2025
February 3, 2025
As rejuvenation research advances from theory to practice, more therapies start making their way into the clinic. 2025 continues with both mouse experiments and human clinical trials. Interviews Cyclarity Launches Human Trial to Cure Atherosclerosis: Recently, Cyclarity Therapeutics announced the launch of a Phase 1 human
Artificially Grown Tissue Repairs Heart Failure in Monkeys
January 31, 2025
German scientists have created lab-grown “patches” of heart muscle tissue derived from pluripotent stem cells. Following a success with rhesus monkeys, they have obtained approval for a human trial [1]. Wear and tear As one of the most hard-working tissues in the body, the heart muscle
Inhibiting a Fundamental Factor in Brain Inflammation
January 30, 2025
Researchers have devised a method of reducing brain inflammation by creating a long-lasting inhibitor of the inflammatory factor NF-κB. Targeting inflammaging at its roots This study, published in the Nature journal Experimental & Molecular Medicine, begins with a discussion of age-related chronic inflammation (inflammaging) and its
Ultrasound as a Tool to Eliminate Senescent Cells
January 29, 2025
A new study suggests that low-intensity pulsed ultrasound (LIPUS) can be beneficial in eliminating senescent cells through the recruitment and activation of immune cells [1]. The double-edged sword of the SASP One of the characteristics of an aging organism is the accumulation of senescent cells. Various
New Database Lets You Know How Processed Your Food Is
January 28, 2025
Scientists have presented GroceryDB, an open-access online database that measures the degree of processing of tens of thousands of products sold in three major US grocery chains [1]. What is ultra-processed food? While there is no universally accepted definition, the NOVA food classification system is widely
Restoring Cellular Proliferation Through Exosomes
January 27, 2025
In Cell Metabolism, researchers have described how a microRNA (miRNA) derived from exosomes generated by human embryonic stem cells (hESCs) restores function and fights senescence in cell cultures and mice. Looking for a better senomorphic This study begins with a discussion of cellular senescence and its