Category: News
Reprogramming Epigenetics to Fight Back Pain
April 7, 2025
A new paper published in the Nature journal Bone Research has found that reprogramming the epigenetics of spinal disc cells reduces senescence and alleviates pain in a rat model. The
World’s First Pig-to-Human Liver Transplant
April 4, 2025
Chinese scientists announced the world’s first successful transplantation of a genetically modified pig liver into a brain-dead patient. This represents an important step towards routinely using pig organs to save
Extracellular Vesicles Restore Some Heart Function to Mice
April 3, 2025
Publishing in Stem Cell Research & Therapy, researchers have found that small extracellular vesicles (sEVs) derived from young mice alleviate heart dysfunction in older mice. Reaffirming an approach These researchers
Activation of Silent X Chromosome Might Improve Cognition
April 2, 2025
Using a mouse model, researchers from UCSF have found that the genes that become activated on the silent X chromosome might explain some sex-dependent differences in cognitive abilities during aging
Scientists Discover a New Mitigator of Senescence
April 1, 2025
Working with flies, mice, and human cells, scientists have demonstrated that a highly conserved protein can modulate cellular senescence, potentially opening a new avenue for future therapies [1]. DNA damage
Rejuvenation Roundup March 2025
April 1, 2025
It’s April Fool’s Day, but until we prevent our bodies from gradually deteriorating, the joke will always be on us. Here’s a no-fooling list of what’s been done to fight
Changes in Aging Adrenal Glands Disturb Hormonal Balance
March 31, 2025
In the Journal of Endocrinological Investigation, reviewers have described how aging affects the adrenal glands, which has downstream effects on the rest of the human body. Small but vital This
Need for Cholesterol May Explain Alzheimer’s Brain Patterns
March 28, 2025
Some brain regions are more vulnerable to Alzheimer’s disease than others. A new study suggests that this might be due to how they uptake cholesterol [1]. Why do some parts
Researchers Find New Target for Spinal Disc Degeneration
March 27, 2025
Researchers have found a new avenue for approaching spinal disc degeneration and published their work in Aging Cell. A very common problem Back problems in the elderly are widely known
Heat May Speed Up Epigenetic Aging in Older Adults
March 26, 2025
A recent study reported significant associations between increased heat days and accelerated epigenetic aging [1]. Heat alters DNA While warm summer days on the beach are pleasant, extreme heat is
Anti-Amyloid Drug Reduces Alzheimer’s Risk in Small Subgroup
March 25, 2025
According to an open-label study from Washington University in St. Louis, the anti-amyloid drug gantenerumab reduced the risk of developing familial Alzheimer’s disease in a subgroup of participants [1]. Is
Joshua “Scotch” McClure: “Infectious Disease Drives Aging”
March 24, 2025
Like many people, I’m both wary of and intrigued by people who make bombastic claims. Years in the longevity field have taught me caution but also that big claims are
Scientists Create Cytoskeleton-Like Structures From RNA
March 21, 2025
In a new study, researchers report producing self-assembling nanotubes and rings made from RNA molecules inside artificial cell-like lipid vesicles. In the future, this technology could facilitate the creation of
A Core Senescence Biomarker Fights Inflammation
March 20, 2025
Researchers publishing in Nature Communications have found that p53, a biomarker and inducer of senescence, suppresses both inflammation and DNA damage in senescent cells. Senescence against cancer One of the
A Hypothalamus Neuropeptide Reduces Aging in a Mouse Model
March 19, 2025
Researchers have improved multiple health metrics in prematurely aged mice by re-establishing the production of neuropeptide Y in the hypothalamus [1]. An essential protein Age-related decline in the function of
Reprogramming Epigenetics to Fight Back Pain
April 7, 2025
A new paper published in the Nature journal Bone Research has found that reprogramming the epigenetics of spinal disc cells reduces senescence and alleviates pain in a rat model. The soft tissue degrades Nucleus pulposus cells, which maintain the discs in the spine [1], are prone
World’s First Pig-to-Human Liver Transplant
April 4, 2025
Chinese scientists announced the world’s first successful transplantation of a genetically modified pig liver into a brain-dead patient. This represents an important step towards routinely using pig organs to save human lives [1]. Where do we get spare parts? The shortage of organs for transplantation is
Extracellular Vesicles Restore Some Heart Function to Mice
April 3, 2025
Publishing in Stem Cell Research & Therapy, researchers have found that small extracellular vesicles (sEVs) derived from young mice alleviate heart dysfunction in older mice. Reaffirming an approach These researchers note that there are a few ways to classify extracellular vesicles. Many of the earlier classifications
Activation of Silent X Chromosome Might Improve Cognition
April 2, 2025
Using a mouse model, researchers from UCSF have found that the genes that become activated on the silent X chromosome might explain some sex-dependent differences in cognitive abilities during aging [1]. XX and XY It is widely known that women live longer than men [2]. Women
Scientists Discover a New Mitigator of Senescence
April 1, 2025
Working with flies, mice, and human cells, scientists have demonstrated that a highly conserved protein can modulate cellular senescence, potentially opening a new avenue for future therapies [1]. DNA damage and senescence Imagine what would happen if the computer code in the software we use daily
Rejuvenation Roundup March 2025
April 1, 2025
It’s April Fool’s Day, but until we prevent our bodies from gradually deteriorating, the joke will always be on us. Here’s a no-fooling list of what’s been done to fight aging last month. Interviews Joshua “Scotch” McClure: “Infectious Disease Drives Aging”: According to McClure, his company’s
Changes in Aging Adrenal Glands Disturb Hormonal Balance
March 31, 2025
In the Journal of Endocrinological Investigation, reviewers have described how aging affects the adrenal glands, which has downstream effects on the rest of the human body. Small but vital This paper begins with an in-depth description of the anatomy of the adrenal glands, which sit atop
Need for Cholesterol May Explain Alzheimer’s Brain Patterns
March 28, 2025
Some brain regions are more vulnerable to Alzheimer’s disease than others. A new study suggests that this might be due to how they uptake cholesterol [1]. Why do some parts of the brain succumb earlier? Despite decades of research and vast amounts of funding, scientists still
Researchers Find New Target for Spinal Disc Degeneration
March 27, 2025
Researchers have found a new avenue for approaching spinal disc degeneration and published their work in Aging Cell. A very common problem Back problems in the elderly are widely known to be caused by a deteriorating spine. Some of these problems are due to the vertebrae
Heat May Speed Up Epigenetic Aging in Older Adults
March 26, 2025
A recent study reported significant associations between increased heat days and accelerated epigenetic aging [1]. Heat alters DNA While warm summer days on the beach are pleasant, extreme heat is not as enjoyable, especially in daily life. It is also not healthy, since extreme heat has
Anti-Amyloid Drug Reduces Alzheimer’s Risk in Small Subgroup
March 25, 2025
According to an open-label study from Washington University in St. Louis, the anti-amyloid drug gantenerumab reduced the risk of developing familial Alzheimer’s disease in a subgroup of participants [1]. Is it about amyloid beta? Despite billions of dollars invested in developing therapies against Alzheimer’s disease, the
Joshua “Scotch” McClure: “Infectious Disease Drives Aging”
March 24, 2025
Like many people, I’m both wary of and intrigued by people who make bombastic claims. Years in the longevity field have taught me caution but also that big claims are not necessarily outlandish, and few people make bigger claims than Joshua “Scotch” McClure, founder and CEO
Scientists Create Cytoskeleton-Like Structures From RNA
March 21, 2025
In a new study, researchers report producing self-assembling nanotubes and rings made from RNA molecules inside artificial cell-like lipid vesicles. In the future, this technology could facilitate the creation of synthetic cells for various research, diagnostic, and therapeutic applications [1]. Paperless origami DNA and RNA molecules
A Core Senescence Biomarker Fights Inflammation
March 20, 2025
Researchers publishing in Nature Communications have found that p53, a biomarker and inducer of senescence, suppresses both inflammation and DNA damage in senescent cells. Senescence against cancer One of the main reasons why cells become senescent is to prevent cancer. The senescence-inducing compound p53, in particular,
A Hypothalamus Neuropeptide Reduces Aging in a Mouse Model
March 19, 2025
Researchers have improved multiple health metrics in prematurely aged mice by re-establishing the production of neuropeptide Y in the hypothalamus [1]. An essential protein Age-related decline in the function of the hypothalamus, a core region of the brain, has been suggested to be a “key factor