Category: News
Engineering T Cells to Fight Brain Cancer
November 18, 2024
Researchers publishing in Nature have reported a new advance in developing chimeric antigen receptor (CAR) T cells to fight solid tumors in the brain. A difficult endeavor CAR T cell-based
Study of Direct Reprogramming Challenges Consensus
November 15, 2024
Scientists have shown that in a direct cellular reprogramming scenario, neurons are produced almost exclusively by a rare subtype of multipotent cells. Their findings, they claim, change our understanding of
Preventing Alzheimer’s Proteins From Accumulating
November 14, 2024
Boosting a key autophagy-related protein discourages a core component of Alzheimer’s from taking hold, according to a study published in Aging Cell. Taking out the trash Autophagy is the maintenance
A Senolytic Accelerates Reproductive Aging in Aged Mice
November 13, 2024
In a new study, researchers tested the impact of the senolytic drug ABT-263 on the reproductive systems of old female mice. ABT-263 treatment did not rescue age-related changes in hormonal
Rozalyn Anderson Explains Caloric Restriction
November 12, 2024
At the University of Wisconsin-Madison, Dr. Rozalyn Anderson is studying one of the oldest-known and yet most powerful anti-aging interventions: caloric restriction (CR). Back in 1935, CR helped launch the
Rejuvenating the Hippocampus With Metabolites
November 11, 2024
Researchers have reported in Aging Cell that injecting specific one-carbon metabolites into the hippocampus can rejuvenate its cells. A small molecule approach Epigenetic alterations have been found to impact the
AI in Longevity: The Reality Today
November 8, 2024
Back in 2006, a website called “The Death Clock” appeared on the internet, with a promise to answer one of life’s greatest questions: “When will I die?” Since then, over
Extracellular Vesicles for Treating Arthritis
November 7, 2024
A study in Pharmacological Research has found that small extracellular vesicles derived from embryonic stem cells (ESC-sEVs) alleviate osteoarthritis in cells and mice. Restoring senescent cells’ function Excessive senescent cell
Mesenchymal Stem Cells Rejuvenate Aged Mice
November 6, 2024
In a new study, the researchers administered human umbilical cord-derived mesenchymal stem cells (HUCMSCs) to aged mice and observed reduced degeneration in multiple organs, changes to microbial composition, metabolic alterations,
Ketogenic Diet Effective Against Multiple Sclerosis in Mice
November 5, 2024
Scientists have found that both a ketogenic diet and oral supplementation with ketone bodies alleviate symptoms of multiple sclerosis, a serious autoimmune disorder, in a mouse model [1]. Keto and
Towards Fine-Tuned Control of Gene Expression
November 4, 2024
In a groundbreaking Nature paper, researchers have developed synthetic regulatory sequences that could prevent targeted gene therapies from having effects in unwanted cell types. More than methylation While methylation is
New Crowdfunding Project Looks for a “Better Rapamycin”
November 1, 2024
Ora Biomedical and the Rapamycin Longevity Lab have launched a project to screen more than 600 mTOR inhibitors in the hope of finding some that are superior to geroscience’s poster
Rejuvenation Roundup October 2024
November 1, 2024
The trick-or-treaters have all gotten their candy, but age-related diseases haunt us still. Here’s what we’ve learned about them in October. LEAF News Team and activities Fall Is Here, but
Senescent Cells Promote Cartilage Regeneration in Rats
October 31, 2024
In a rat experiment, researchers publishing in Aging Cell have found that senescent cells and SASP factors are key in regenerating knee cartilage. Not always negative Cellular senescence is widely
NOVOS Supplement: Lifespan Extension in Male Mice
October 30, 2024
A recent preprint study suggests that a NOVOS supplement can improve healthspan and extend lifespan in male mice [1]. Multiple ingredients, one goal This preprint’s authors start by discussing dietary
Engineering T Cells to Fight Brain Cancer
November 18, 2024
Researchers publishing in Nature have reported a new advance in developing chimeric antigen receptor (CAR) T cells to fight solid tumors in the brain. A difficult endeavor CAR T cell-based therapies are normally discussed in the context of blood cancers, as getting them to effectively attack
Study of Direct Reprogramming Challenges Consensus
November 15, 2024
Scientists have shown that in a direct cellular reprogramming scenario, neurons are produced almost exclusively by a rare subtype of multipotent cells. Their findings, they claim, change our understanding of reprogramming, but not everyone agrees [1]. Direct action In the world of cellular reprogramming, the two
Preventing Alzheimer’s Proteins From Accumulating
November 14, 2024
Boosting a key autophagy-related protein discourages a core component of Alzheimer’s from taking hold, according to a study published in Aging Cell. Taking out the trash Autophagy is the maintenance process of the cell, in which autophagosomes engulf unwanted organelles and other material and fuse together
A Senolytic Accelerates Reproductive Aging in Aged Mice
November 13, 2024
In a new study, researchers tested the impact of the senolytic drug ABT-263 on the reproductive systems of old female mice. ABT-263 treatment did not rescue age-related changes in hormonal levels, further depleted ovarian reserves, and didn’t improve most of the tested signs of reproductive aging
Rozalyn Anderson Explains Caloric Restriction
November 12, 2024
At the University of Wisconsin-Madison, Dr. Rozalyn Anderson is studying one of the oldest-known and yet most powerful anti-aging interventions: caloric restriction (CR). Back in 1935, CR helped launch the entire longevity field when a pioneering study by Clive McCay and his colleagues at Cornell University
Rejuvenating the Hippocampus With Metabolites
November 11, 2024
Researchers have reported in Aging Cell that injecting specific one-carbon metabolites into the hippocampus can rejuvenate its cells. A small molecule approach Epigenetic alterations have been found to impact the neuroplasticity of the brain, leading to problems with learning and memory [1]. This research team has
AI in Longevity: The Reality Today
November 8, 2024
Back in 2006, a website called “The Death Clock” appeared on the internet, with a promise to answer one of life’s greatest questions: “When will I die?” Since then, over 60 million people have used the site, which gives a somewhat grim countdown to the day
Extracellular Vesicles for Treating Arthritis
November 7, 2024
A study in Pharmacological Research has found that small extracellular vesicles derived from embryonic stem cells (ESC-sEVs) alleviate osteoarthritis in cells and mice. Restoring senescent cells’ function Excessive senescent cell buildup in cartilage has negative effects and leads to osteoarthritis [1]. Constant exposure to SASP factors
Mesenchymal Stem Cells Rejuvenate Aged Mice
November 6, 2024
In a new study, the researchers administered human umbilical cord-derived mesenchymal stem cells (HUCMSCs) to aged mice and observed reduced degeneration in multiple organs, changes to microbial composition, metabolic alterations, improvements in behavior and ability, and reduced fearfulness [1]. Therapeutic potential Earlier this year, we reported
Ketogenic Diet Effective Against Multiple Sclerosis in Mice
November 5, 2024
Scientists have found that both a ketogenic diet and oral supplementation with ketone bodies alleviate symptoms of multiple sclerosis, a serious autoimmune disorder, in a mouse model [1]. Keto and autoimmune diseases In ketogenic diets, the vast majority of calories are derived from fat, some from
Towards Fine-Tuned Control of Gene Expression
November 4, 2024
In a groundbreaking Nature paper, researchers have developed synthetic regulatory sequences that could prevent targeted gene therapies from having effects in unwanted cell types. More than methylation While methylation is the most well-known regulator of gene expression, it isn’t the only thing that determines what is
New Crowdfunding Project Looks for a “Better Rapamycin”
November 1, 2024
Ora Biomedical and the Rapamycin Longevity Lab have launched a project to screen more than 600 mTOR inhibitors in the hope of finding some that are superior to geroscience’s poster child, rapamycin. Better than chance Rapamycin, one of the most potent compounds for prolonging lifespan in
Rejuvenation Roundup October 2024
November 1, 2024
The trick-or-treaters have all gotten their candy, but age-related diseases haunt us still. Here’s what we’ve learned about them in October. LEAF News Team and activities Fall Is Here, but It’s Full Steam Ahead for Lifespan.io: For those of us living in the Northern Hemisphere, the
Senescent Cells Promote Cartilage Regeneration in Rats
October 31, 2024
In a rat experiment, researchers publishing in Aging Cell have found that senescent cells and SASP factors are key in regenerating knee cartilage. Not always negative Cellular senescence is widely known to have negative effects, to the point that it is one of the hallmarks of
NOVOS Supplement: Lifespan Extension in Male Mice
October 30, 2024
A recent preprint study suggests that a NOVOS supplement can improve healthspan and extend lifespan in male mice [1]. Multiple ingredients, one goal This preprint’s authors start by discussing dietary supplements’ beneficial effects on lifespan and markers of healthspan in multiple organisms and their possible additive