Category: News
The Best Talks of GSA 2024
November 26, 2024
Today, we bring you a selection of presentations from the annual conference organized by the Gerontological Society of America. Most of our savvy readers, if asked to name the biggest
Finding Cells That Send Signals Against Arthritis
November 25, 2024
In Aging, researchers have reported that deriving extracellular vesicles from mesenchymal stromal cells (MSCs) in fat tissue has beneficial effects in models of osteoarthritis. Which source to use? Earlier this
How Exercise Preserves Function in Motor Nerves
November 21, 2024
In Aging Cell, researchers have described the specific cell types that give exercise protective effects against motor nerve degeneration. A different level of back problems With aging, the prevalence of
Dietary Diversity Is Associated With Delayed Aging
November 20, 2024
An analysis of data from over twenty thousand people has indicated that greater dietary diversity is associated with slower biological aging [1]. Your health is what you eat Good dietary
Intranasal Spray Alleviates Early Alzheimer’s in Mice
November 19, 2024
A novel therapy based on induced neuronal stem cells shows promise in a mouse model of Alzheimer’s disease – and it can be administered intranasally [1]. Who needs cells? Stem
Engineering T Cells to Fight Brain Cancer
November 18, 2024
Researchers publishing in Nature have reported a new advance in developing chimeric antigen receptor (CAR) T cells to fight solid tumors in the brain. A difficult endeavor CAR T cell-based
Study of Direct Reprogramming Challenges Consensus
November 15, 2024
Scientists have shown that in a direct cellular reprogramming scenario, neurons are produced almost exclusively by a rare subtype of multipotent cells. Their findings, they claim, change our understanding of
Preventing Alzheimer’s Proteins From Accumulating
November 14, 2024
Boosting a key autophagy-related protein discourages a core component of Alzheimer’s from taking hold, according to a study published in Aging Cell. Taking out the trash Autophagy is the maintenance
A Senolytic Accelerates Reproductive Aging in Aged Mice
November 13, 2024
In a new study, researchers tested the impact of the senolytic drug ABT-263 on the reproductive systems of old female mice. ABT-263 treatment did not rescue age-related changes in hormonal
Rozalyn Anderson Explains Caloric Restriction
November 12, 2024
At the University of Wisconsin-Madison, Dr. Rozalyn Anderson is studying one of the oldest-known and yet most powerful anti-aging interventions: caloric restriction (CR). Back in 1935, CR helped launch the
Rejuvenating the Hippocampus With Metabolites
November 11, 2024
Researchers have reported in Aging Cell that injecting specific one-carbon metabolites into the hippocampus can rejuvenate its cells. A small molecule approach Epigenetic alterations have been found to impact the
AI in Longevity: The Reality Today
November 8, 2024
Back in 2006, a website called “The Death Clock” appeared on the internet, with a promise to answer one of life’s greatest questions: “When will I die?” Since then, over
Extracellular Vesicles for Treating Arthritis
November 7, 2024
A study in Pharmacological Research has found that small extracellular vesicles derived from embryonic stem cells (ESC-sEVs) alleviate osteoarthritis in cells and mice. Restoring senescent cells’ function Excessive senescent cell
Mesenchymal Stem Cells Rejuvenate Aged Mice
November 6, 2024
In a new study, the researchers administered human umbilical cord-derived mesenchymal stem cells (HUCMSCs) to aged mice and observed reduced degeneration in multiple organs, changes to microbial composition, metabolic alterations,
Ketogenic Diet Effective Against Multiple Sclerosis in Mice
November 5, 2024
Scientists have found that both a ketogenic diet and oral supplementation with ketone bodies alleviate symptoms of multiple sclerosis, a serious autoimmune disorder, in a mouse model [1]. Keto and
The Best Talks of GSA 2024
November 26, 2024
Today, we bring you a selection of presentations from the annual conference organized by the Gerontological Society of America. Most of our savvy readers, if asked to name the biggest gerontology conference, would probably go with the venerable ARDD in Copenhagen or the new favorite, Hevolution
Finding Cells That Send Signals Against Arthritis
November 25, 2024
In Aging, researchers have reported that deriving extracellular vesicles from mesenchymal stromal cells (MSCs) in fat tissue has beneficial effects in models of osteoarthritis. Which source to use? Earlier this month, we wrote about how small extracellular vesicles derived from embryonic cells (ESC-sEVs) alleviate arthritis in
How Exercise Preserves Function in Motor Nerves
November 21, 2024
In Aging Cell, researchers have described the specific cell types that give exercise protective effects against motor nerve degeneration. A different level of back problems With aging, the prevalence of nerves connecting to muscle tissue dwindles, a phenomenon known as denervation [1]. This has been linked
Dietary Diversity Is Associated With Delayed Aging
November 20, 2024
An analysis of data from over twenty thousand people has indicated that greater dietary diversity is associated with slower biological aging [1]. Your health is what you eat Good dietary habits are linked to many health benefits, and different diets were previously reported to impact the
Intranasal Spray Alleviates Early Alzheimer’s in Mice
November 19, 2024
A novel therapy based on induced neuronal stem cells shows promise in a mouse model of Alzheimer’s disease – and it can be administered intranasally [1]. Who needs cells? Stem cell therapies have made great strides in recent decades. They have been successfully employed against numerous
Engineering T Cells to Fight Brain Cancer
November 18, 2024
Researchers publishing in Nature have reported a new advance in developing chimeric antigen receptor (CAR) T cells to fight solid tumors in the brain. A difficult endeavor CAR T cell-based therapies are normally discussed in the context of blood cancers, as getting them to effectively attack
Study of Direct Reprogramming Challenges Consensus
November 15, 2024
Scientists have shown that in a direct cellular reprogramming scenario, neurons are produced almost exclusively by a rare subtype of multipotent cells. Their findings, they claim, change our understanding of reprogramming, but not everyone agrees [1]. Direct action In the world of cellular reprogramming, the two
Preventing Alzheimer’s Proteins From Accumulating
November 14, 2024
Boosting a key autophagy-related protein discourages a core component of Alzheimer’s from taking hold, according to a study published in Aging Cell. Taking out the trash Autophagy is the maintenance process of the cell, in which autophagosomes engulf unwanted organelles and other material and fuse together
A Senolytic Accelerates Reproductive Aging in Aged Mice
November 13, 2024
In a new study, researchers tested the impact of the senolytic drug ABT-263 on the reproductive systems of old female mice. ABT-263 treatment did not rescue age-related changes in hormonal levels, further depleted ovarian reserves, and didn’t improve most of the tested signs of reproductive aging
Rozalyn Anderson Explains Caloric Restriction
November 12, 2024
At the University of Wisconsin-Madison, Dr. Rozalyn Anderson is studying one of the oldest-known and yet most powerful anti-aging interventions: caloric restriction (CR). Back in 1935, CR helped launch the entire longevity field when a pioneering study by Clive McCay and his colleagues at Cornell University
Rejuvenating the Hippocampus With Metabolites
November 11, 2024
Researchers have reported in Aging Cell that injecting specific one-carbon metabolites into the hippocampus can rejuvenate its cells. A small molecule approach Epigenetic alterations have been found to impact the neuroplasticity of the brain, leading to problems with learning and memory [1]. This research team has
AI in Longevity: The Reality Today
November 8, 2024
Back in 2006, a website called “The Death Clock” appeared on the internet, with a promise to answer one of life’s greatest questions: “When will I die?” Since then, over 60 million people have used the site, which gives a somewhat grim countdown to the day
Extracellular Vesicles for Treating Arthritis
November 7, 2024
A study in Pharmacological Research has found that small extracellular vesicles derived from embryonic stem cells (ESC-sEVs) alleviate osteoarthritis in cells and mice. Restoring senescent cells’ function Excessive senescent cell buildup in cartilage has negative effects and leads to osteoarthritis [1]. Constant exposure to SASP factors
Mesenchymal Stem Cells Rejuvenate Aged Mice
November 6, 2024
In a new study, the researchers administered human umbilical cord-derived mesenchymal stem cells (HUCMSCs) to aged mice and observed reduced degeneration in multiple organs, changes to microbial composition, metabolic alterations, improvements in behavior and ability, and reduced fearfulness [1]. Therapeutic potential Earlier this year, we reported
Ketogenic Diet Effective Against Multiple Sclerosis in Mice
November 5, 2024
Scientists have found that both a ketogenic diet and oral supplementation with ketone bodies alleviate symptoms of multiple sclerosis, a serious autoimmune disorder, in a mouse model [1]. Keto and autoimmune diseases In ketogenic diets, the vast majority of calories are derived from fat, some from