Category: News
Cryptic Exons for Targeting Neurodegenerative Disease
October 8, 2024
Amyotrophic lateral sclerosis (ALS) only affects a fraction of cells and must be treated with high specificity. Scientists have achieved that by targeting mRNA sites associated with the disease [1].
Senescent Macrophages: A Unique Target
October 7, 2024
In Aging, researchers have published a new study on a tool meant for analyzing macrophage senescence along with differences between inflammaging and regular inflammation. Macrophages are driven to senescence Previous
Fall Is Here, but It’s Full Steam Ahead for Lifespan.io
October 7, 2024
For those of us living in the Northern Hemisphere, the summer days are gone and the cooler days of fall have arrived. While it’s time to ditch the beachwear for
UK Citizens Are Healthier Than Americans, but Don’t Feel So
October 4, 2024
A new study shows that in midlife, United States citizens are less healthy than their British counterparts. The latter, however, smoke more and rate their health worse [1]. I’ll show
Exercise Intensity, Duration, and Amount All Matter
October 3, 2024
In the European Journal of Protective Cardiology, researchers have published evidence that the intensity of exercise is somewhat more important than volume in reducing all-cause mortality risk, although both have
mTOR and SGLT-2 Inhibitors Impact Age-Related Processes
October 2, 2024
The authors of a recent review propose that there may be positive synergistic effects from combining mTOR inhibitors and sodium-glucose co-transporter-2 (SGLT-2) inhibitors [1]. Inhibition of two molecules is better
Boosting Autophagy in Astrocytes Might Help Cure Alzheimer’s
October 1, 2024
With Alzheimer’s disease, most of the focus has been on neurons. A new study’s researchers suggest boosting the process of cellular junk removal in astrocytes, brain cells that perform maintenance
Rejuvenation Roundup September 2024
October 1, 2024
This past month, we’ve covered plenty of research news and information about conferences, but now we have some news of our own. Here’s what’s been happening in the rejuvenation biotechnology
Lifespan.io and SENS Research Foundation Unite
October 1, 2024
October 1, 2024 – Lifespan.io (Lifespan Extension Advocacy Foundation) and SENS Research Foundation are excited to announce the completion of their merger, forming a new 501(c)(3) non-profit: Lifespan Research Institute.
How Lifesaving Treatments Can Cause Long-Term Harm
September 30, 2024
A research paper published in Aging explored a link between breast cancer, hematopoietic cell transplants (HCTs), an increase in physical frailty, and cellular senescence. Treatment comes at a cost HCTs
Study Suggests Mammals’ Lifespan Is Limited by Epigenetics
September 30, 2024
Juan José Alba-Linares and his research team have published a preprint study that examined why different animals age at different rates. They found that epigenetic changes over time could explain
A Bank of Centenarian Stem Cells
September 29, 2024
Researchers are keeping a bank of induced pluripotent stem cells (iPSCs) derived from centenarians and their descendants. They describe the purpose of this bank and its uses in Aging Cell.
Reprogramming Senescent Cells Extends Lifespan in Mice
September 27, 2024
Dr. Belmonte’s group at Altos Labs targeted stressed and senescent cells with partial reprogramming, producing large increases in lifespan in male mice [1]. What are they doing there? Since the
A Likely Beneficial Compound Also Predicts Mortality
September 26, 2024
Researchers publishing in Aging have found that fibroblast growth factor 21 (FGF21), an apparently beneficial protein naturally produced by the human body, heralds a greater likelihood of death. Multiple documented
Metformin Slows Aging in Non-Human Primates
September 26, 2024
In a new study, metformin, which has already shown good results in rodents and in human epidemiological studies, alleviated multiple signs of aging in male cynomolgus monkeys [1]. Now in
Cryptic Exons for Targeting Neurodegenerative Disease
October 8, 2024
Amyotrophic lateral sclerosis (ALS) only affects a fraction of cells and must be treated with high specificity. Scientists have achieved that by targeting mRNA sites associated with the disease [1]. Cryptic behavior ALS is a neurodegenerative disease in which age is a major factor. While it
Senescent Macrophages: A Unique Target
October 7, 2024
In Aging, researchers have published a new study on a tool meant for analyzing macrophage senescence along with differences between inflammaging and regular inflammation. Macrophages are driven to senescence Previous work has found that excessive senescent cells are uniquely harmful to macrophages, recruiting them into senescence
Fall Is Here, but It’s Full Steam Ahead for Lifespan.io
October 7, 2024
For those of us living in the Northern Hemisphere, the summer days are gone and the cooler days of fall have arrived. While it’s time to ditch the beachwear for chunky sweaters and a hot chocolate by the fire, things have been heating up in the
UK Citizens Are Healthier Than Americans, but Don’t Feel So
October 4, 2024
A new study shows that in midlife, United States citizens are less healthy than their British counterparts. The latter, however, smoke more and rate their health worse [1]. I’ll show you my health if you show me yours It is well-known that despite the US being
Exercise Intensity, Duration, and Amount All Matter
October 3, 2024
In the European Journal of Protective Cardiology, researchers have published evidence that the intensity of exercise is somewhat more important than volume in reducing all-cause mortality risk, although both have significant correlations. The questions of how long and how much Conventional wisdom had maintained that exercise
mTOR and SGLT-2 Inhibitors Impact Age-Related Processes
October 2, 2024
The authors of a recent review propose that there may be positive synergistic effects from combining mTOR inhibitors and sodium-glucose co-transporter-2 (SGLT-2) inhibitors [1]. Inhibition of two molecules is better than one mTOR is a well-known molecule in aging research. Inhibition of mTOR has been shown
Boosting Autophagy in Astrocytes Might Help Cure Alzheimer’s
October 1, 2024
With Alzheimer’s disease, most of the focus has been on neurons. A new study’s researchers suggest boosting the process of cellular junk removal in astrocytes, brain cells that perform maintenance tasks, as a new pathway [1]. Looking at a different cell type Accumulation of amyloid beta,
Rejuvenation Roundup September 2024
October 1, 2024
This past month, we’ve covered plenty of research news and information about conferences, but now we have some news of our own. Here’s what’s been happening in the rejuvenation biotechnology world. LEAF News Lifespan.io and SENS Research Foundation Unite to Launch a New Powerhouse in Aging
Lifespan.io and SENS Research Foundation Unite
October 1, 2024
October 1, 2024 – Lifespan.io (Lifespan Extension Advocacy Foundation) and SENS Research Foundation are excited to announce the completion of their merger, forming a new 501(c)(3) non-profit: Lifespan Research Institute. Lifespan Research Institute (“LRI”) will develop, promote, and ensure widespread access to regenerative medicine solutions targeting
How Lifesaving Treatments Can Cause Long-Term Harm
September 30, 2024
A research paper published in Aging explored a link between breast cancer, hematopoietic cell transplants (HCTs), an increase in physical frailty, and cellular senescence. Treatment comes at a cost HCTs and breast cancer treatment are lifesaving procedures. However, chemotherapy in breast cancer sharply increases p16INK4a, a
Study Suggests Mammals’ Lifespan Is Limited by Epigenetics
September 30, 2024
Juan José Alba-Linares and his research team have published a preprint study that examined why different animals age at different rates. They found that epigenetic changes over time could explain why some animals live longer and estimated an upper limit for mammalian lifespan [1]. A problem
A Bank of Centenarian Stem Cells
September 29, 2024
Researchers are keeping a bank of induced pluripotent stem cells (iPSCs) derived from centenarians and their descendants. They describe the purpose of this bank and its uses in Aging Cell. A category of their own Centenarians don’t merely live for a hundred years; they spend more
Reprogramming Senescent Cells Extends Lifespan in Mice
September 27, 2024
Dr. Belmonte’s group at Altos Labs targeted stressed and senescent cells with partial reprogramming, producing large increases in lifespan in male mice [1]. What are they doing there? Since the discovery of cellular reprogramming almost two decades ago, a lot of hopes have been put into
A Likely Beneficial Compound Also Predicts Mortality
September 26, 2024
Researchers publishing in Aging have found that fibroblast growth factor 21 (FGF21), an apparently beneficial protein naturally produced by the human body, heralds a greater likelihood of death. Multiple documented benefits FGF21 plays crucial roles in the human body. Secreted by the liver and many other
Metformin Slows Aging in Non-Human Primates
September 26, 2024
In a new study, metformin, which has already shown good results in rodents and in human epidemiological studies, alleviated multiple signs of aging in male cynomolgus monkeys [1]. Now in monkeys Metformin, a well-established anti-diabetes drug, has been touted as a possible geroprotector since a study