Lifespan Research Institute

Category: News

Parkinson's

Mitochondria Injection Alleviates Parkinson’s in Mice

Scientists have tested a novel method of providing cells with healthy mitochondria to fight Parkinson’s disease [1]. Replacing damaged mitochondria Parkinson’s disease is the second-most prevalent neurodegenerative disorder, and it

Reason Interview

New Gene Therapy Reverses Atherosclerosis In Mice

Repair Biotechnologies, a company based in Syracuse, New York, has announced findings from early research suggesting that its technology can quickly stop the advancement of atherosclerosis. While these preclinical results

Neurons

Reprogramming Helps Old Mice Produce More Neurons

Scientists have found that partial cellular reprogramming, both full-body and restricted to specific brain regions, rescues neurogenesis in the brains of old mice [1]. Cells going back in time Partial

Cell targeting

Finding Senolytics to Stop Lung Disease

Researchers publishing in the Journal of Clinical Investigation have developed a new method of screening for compounds, and they found one that appears to directly attack senescent cells involved in

Intestinal Villi

Senolytic CAR T Cells Rescue Intestinal Aging in Mice

Scientists have demonstrated that CAR T cells can be employed against senescent intestinal stem cells, improving regeneration and ameliorating age-related symptoms such as “leaky gut” [1]. Cell-on-cell warfare Cellular senescence

Socializing elderly

More Social Connections Associated with Slower Aging

Recent research has contributed to the growing body of evidence regarding social isolation, loneliness, and biological aging [1]. Social isolation is not generally screened for During doctor visits, patients are

Desci March

Longevity and DeSci Recap – March 2024

Welcome back for the latest edition of the Longevity and DeSci Recap. This March has seen a swarm of activity as the longevity and DeSci world has sprung to renewed

Obesity and inflammation

An Inflammatory Molecule May Also Encourage Obesity

A team of researchers has waded into a controversial and contradictory area of study, publishing information on the link between obesity and an inflammatory molecule that increases with aging. A context-dependent molecule The authors point out previous research that singled out the interleukin IL-6, a key

Parkinson's

Mitochondria Injection Alleviates Parkinson’s in Mice

Scientists have tested a novel method of providing cells with healthy mitochondria to fight Parkinson’s disease [1]. Replacing damaged mitochondria Parkinson’s disease is the second-most prevalent neurodegenerative disorder, and it affects 10 million people worldwide. The disease is age-related, as its prevalence rises rapidly in people

Epigenetic protection

Very Long-Lived People Have Protected Epigenetics

A team of researchers has reported in Aging Cell that longer-lived Chinese women have less epigenetic noise in crucial areas of the genome. Order and disorder We have previously reported that the accumulation of epigenetic noise appears to be the main cause of epigenetic alterations. Multiple

Reason Interview

New Gene Therapy Reverses Atherosclerosis In Mice

Repair Biotechnologies, a company based in Syracuse, New York, has announced findings from early research suggesting that its technology can quickly stop the advancement of atherosclerosis. While these preclinical results are in mice, this approach has the potential for treating atherosclerosis in humans. In March, the

Medications

Some Medications Associated with Improved Aging Biomarkers

The authors of a recent study published in Aging Cell tested 21 groups of medication used by the elderly and reported that some of them impact aging biomarkers [1]. Repurposing existing drugs to fight aging The search for drugs that slow aging includes finding new compounds

Neurons

Reprogramming Helps Old Mice Produce More Neurons

Scientists have found that partial cellular reprogramming, both full-body and restricted to specific brain regions, rescues neurogenesis in the brains of old mice [1]. Cells going back in time Partial reprogramming improves various health metrics and increases lifespan in animal models [2]. For instance, Dr. David

Cell targeting

Finding Senolytics to Stop Lung Disease

Researchers publishing in the Journal of Clinical Investigation have developed a new method of screening for compounds, and they found one that appears to directly attack senescent cells involved in lung fibrosis. A disease of senescence Senescent cells are a major part of an age-related lung

Obesity with age

Scientists Discover a New Mechanism of Age-Related Obesity

A new study suggests that the reason why aging is associated with obesity lies in specific neurons found in the brain [1]. Tell that to the brain It is often hard to lose weight, and it becomes harder with age. While it seems simple enough to eat

Seven compounds

Small Molecules Reverse Many Age-Related Changes in Cells

A team of Harvard researchers has published a paper in eLife detailing the downstream effects of small molecule partial cellular reprogramming. Rejuvenating cells from the ground up We have recently reported on a review of partial cellular reprogramming that used a cocktail of small molecules named

SENS Lifespan.io Merge Announcement

SENS Research Foundation and Lifespan.io Announce Merge

NEW YORK, April 3, 2024 – In a groundbreaking announcement set to impact the future of longevity research and outreach, two historic longevity nonprofits – SENS Research Foundation and Lifespan.io (Lifespan Extension Advocacy Foundation) – have unveiled plans to merge, upon completion of regulatory approvals. Lifespan.io,

Intestinal Villi

Senolytic CAR T Cells Rescue Intestinal Aging in Mice

Scientists have demonstrated that CAR T cells can be employed against senescent intestinal stem cells, improving regeneration and ameliorating age-related symptoms such as “leaky gut” [1]. Cell-on-cell warfare Cellular senescence is a heterogeneous phenomenon in which cells stop dividing and malfunction, driving up inflammation. While senescent

Socializing elderly

More Social Connections Associated with Slower Aging

Recent research has contributed to the growing body of evidence regarding social isolation, loneliness, and biological aging [1]. Social isolation is not generally screened for During doctor visits, patients are often screened for many physical conditions. However, screening for social isolation in the clinic is not

Desci March

Longevity and DeSci Recap – March 2024

Welcome back for the latest edition of the Longevity and DeSci Recap. This March has seen a swarm of activity as the longevity and DeSci world has sprung to renewed life. Between the many upcoming conferences, latest investment news, and innovations happening at the Vitalia pop-up

A4LI Speaker

Longevity Gets Political at an Unprecedented DC Event

The longevity community has always been a niche one, but many of its members realize this is not how we defeat aging. This goal requires immense resources as well as political and regulatory changes that can only be obtained at a national level. With all our

E-cigarette and cigarettes

The Epigenetic Similarities Between E-Cigarettes and Smoking

The authors of a new paper in Cancer Research have published the surprising finding that cigarettes and e-cigarettes have some similar effects on DNA methylation that have been reported to lead to cancer. Harm reduction might not truly reduce harm It is well-known that cigarettes are