Category: News
A Small Molecule to Restore the Liver
March 18, 2024
In Cell, a team of researchers, including the founders of the biotech company HepaRegeniX, has published a paper on HRX215, a molecule that encourages liver regeneration. When the liver doesn’t
Study Suggests 14 Existing Drugs Increase Human Lifespan
March 15, 2024
Scientists have used a huge database to find links between existing drugs and human lifespan. Only 14 of more than 400 showed a positive correlation [1]. Reinventing the wheel? One
Controlling a Protein to Stop Obesity
March 14, 2024
In GeroScience, researchers have described how turning off a specific protein prevents mice from getting obese in old age. Mimicking hypoxia Hypoxia-inducible factors (HIFs) are a collection of three proteins
InSilico Shares Details on AI-Generated Drug Candidate
March 14, 2024
In a new paper, InSilico has reported on its impressive success with a drug against idiopathic pulmonary fibrosis that was created by AI “from A to Z” and is currently
Senolytic Activity of Drug-Polyphenol Combinations
March 13, 2024
The authors of a paper published in Pharmaceuticals tested multiple drug-polyphenol combinations to find the ones with the best senolytic properties [1]. Targeting senescent cells in lung diseases Various drugs
Hard Science and Long-Shot Ideas Meet in Vitalia
March 12, 2024
Vitalia, the longevity pop-up city that came into being earlier this year on the island of Roatan off the coast of Honduras, was a first-of-its-kind event that we will more
Reprogramming Cells to Research Aging
March 11, 2024
Instead of using cellular reprogramming to directly treat age-related diseases, a perspective published in Nature Communications focuses on the opposite: using reprogrammed cells to form aged tissues and organoids on
High Protein Consumption May Drive Atherosclerosis
March 8, 2024
A new study suggests that increased protein intake, specifically of the amino acid leucine, can exacerbate atherosclerosis by inhibiting autophagy in macrophages [1]. Protein: friend or foe? The protein we
Lowering the Bar to Invest in Longevity
March 7, 2024
Maximon, Marcuard Heritage, and GenTwo have announced the launch of a new longevity-related investment opportunity. Their proposal allows professional investors to get access to Maximon’s portfolio of longevity companies via
Looking for Safety in Epigenetic Rejuvenation
March 7, 2024
In Nature Communications, Ali Yücel and Vadim Gladyshev have published a review of the current state of the art in partial cellular reprogramming, detailing what this technology does and how
Intermittent Rapamycin Lessens Negative Effects in Mice
March 6, 2024
A recent Molecular Metabolism paper dives into the differences between intermittent and chronic rapamycin treatment and its differential impact on male and female mice [1]. The dark side of rapamycin
Decreasing Autophagy Might Reverse Ovarian Aging
March 5, 2024
Experimenting in vitro and in mice, scientists have found that ovarian aging is linked to increased autophagy and apoptosis in granulosa cells and that it can be reversed by an
Using Ultrasound to Assist Gene Therapy
March 4, 2024
A new publication in iScience has described a novel way in which heart tissue can be encouraged to accept a gene therapy by using ultrasound to create cavitation bubbles. A
Longevity and DeSci Recap – February 2024
March 4, 2024
Last month has been a hive of activity in the longevity finance sphere, with a number of significant fundings taking place that are set to generate new lifespan solutions for
Ultra-Processed Food Linked to Numerous Health Risks
March 1, 2024
A new massive umbrella review of epidemiological meta-analyses reinforces the idea that ultra-processed food is bad for most aspects of human health [1]. Is it even food? Many words have
A Small Molecule to Restore the Liver
March 18, 2024
In Cell, a team of researchers, including the founders of the biotech company HepaRegeniX, has published a paper on HRX215, a molecule that encourages liver regeneration. When the liver doesn’t regenerate The researchers note that the liver has a “nearly unlimited regenerative potential” under healthy circumstances.
Study Suggests 14 Existing Drugs Increase Human Lifespan
March 15, 2024
Scientists have used a huge database to find links between existing drugs and human lifespan. Only 14 of more than 400 showed a positive correlation [1]. Reinventing the wheel? One of the subfields in geroscience was born from the idea that some drugs currently in use
Controlling a Protein to Stop Obesity
March 14, 2024
In GeroScience, researchers have described how turning off a specific protein prevents mice from getting obese in old age. Mimicking hypoxia Hypoxia-inducible factors (HIFs) are a collection of three proteins that are sensitive to oxygen, and, like their name suggests, they normally activate when a cell
InSilico Shares Details on AI-Generated Drug Candidate
March 14, 2024
In a new paper, InSilico has reported on its impressive success with a drug against idiopathic pulmonary fibrosis that was created by AI “from A to Z” and is currently in Phase 2 trials [1]. AI against aging Many people in the longevity community hope that
Senolytic Activity of Drug-Polyphenol Combinations
March 13, 2024
The authors of a paper published in Pharmaceuticals tested multiple drug-polyphenol combinations to find the ones with the best senolytic properties [1]. Targeting senescent cells in lung diseases Various drugs are being used to address some of the problems associated with cellular senescence. For example, some
Hard Science and Long-Shot Ideas Meet in Vitalia
March 12, 2024
Vitalia, the longevity pop-up city that came into being earlier this year on the island of Roatan off the coast of Honduras, was a first-of-its-kind event that we will more extensively cover later. Today, we are happy to present a roundup of the talks from the
Reprogramming Cells to Research Aging
March 11, 2024
Instead of using cellular reprogramming to directly treat age-related diseases, a perspective published in Nature Communications focuses on the opposite: using reprogrammed cells to form aged tissues and organoids on which to conduct experiments. Why not just use donors? Obviously, there is no shortage of age-related
High Protein Consumption May Drive Atherosclerosis
March 8, 2024
A new study suggests that increased protein intake, specifically of the amino acid leucine, can exacerbate atherosclerosis by inhibiting autophagy in macrophages [1]. Protein: friend or foe? The protein we get from food is indispensable, as it allows us to produce our own proteins, but the
Lowering the Bar to Invest in Longevity
March 7, 2024
Maximon, Marcuard Heritage, and GenTwo have announced the launch of a new longevity-related investment opportunity. Their proposal allows professional investors to get access to Maximon’s portfolio of longevity companies via an actively managed certificate (AMC). According to Maximon, there have been many requests to launch an
Looking for Safety in Epigenetic Rejuvenation
March 7, 2024
In Nature Communications, Ali Yücel and Vadim Gladyshev have published a review of the current state of the art in partial cellular reprogramming, detailing what this technology does and how it might be used safely. Affecting methylation directly This paper begins by treading familiar ground on
Intermittent Rapamycin Lessens Negative Effects in Mice
March 6, 2024
A recent Molecular Metabolism paper dives into the differences between intermittent and chronic rapamycin treatment and its differential impact on male and female mice [1]. The dark side of rapamycin Rapamycin doesn’t need much introduction in the lifespan extension community. This mTOR inhibitor has been shown
Decreasing Autophagy Might Reverse Ovarian Aging
March 5, 2024
Experimenting in vitro and in mice, scientists have found that ovarian aging is linked to increased autophagy and apoptosis in granulosa cells and that it can be reversed by an estrogen receptor inhibitor [1]. When ovaries get tired Female reproductive aging is an intriguing phenomenon that
Using Ultrasound to Assist Gene Therapy
March 4, 2024
A new publication in iScience has described a novel way in which heart tissue can be encouraged to accept a gene therapy by using ultrasound to create cavitation bubbles. A little-known target and a new delivery vector This paper begins with a discussion of S-adenosylhomocysteine (SAH),
Longevity and DeSci Recap – February 2024
March 4, 2024
Last month has been a hive of activity in the longevity finance sphere, with a number of significant fundings taking place that are set to generate new lifespan solutions for the future. Highlights include Yuva Biosciences’ $7.5 million for anti-hair loss tech, Tagomics’ £6.7 million for
Ultra-Processed Food Linked to Numerous Health Risks
March 1, 2024
A new massive umbrella review of epidemiological meta-analyses reinforces the idea that ultra-processed food is bad for most aspects of human health [1]. Is it even food? Many words have been uttered about the dangers of ultra-processed food, so can another study add anything new? The