Category: News
Rejuvenation Roundup November 2025
December 1, 2025
Many researchers in the United States have finished eating turkey and begun shopping, but their work continues. Here’s what people around the world have been doing to fight aging in
A Subtype of T Cells Counters Senescence in Mice
November 28, 2025
Scientists have discovered that a cytotoxic subtype of CD4 T cells, which is enriched in old people, helps control cellular senescence. This hints at a new type of anti-senescence strategy
An AI-Based System Has Found a Potential Longevity Drug
November 27, 2025
In a preprint published in bioRxiv, Prof. Vadim Gladyshev and a team of researchers have used an artificial intelligence-based system to discover a wide variety of potential interventions, including a
The Roles of Phenylalanine and Tyrosine in Lifespan
November 26, 2025
A recent study investigated the impact of two amino acids, phenylalanine and tyrosine, on lifespan using UK Biobank data. The researchers reported an association between tyrosine and shorter lifespan, with
Fixing Lysosomes Improves Blood Stem Cell Function
November 25, 2025
In a recent study, scientists have demonstrated that lysosomal dysfunction actively decreases the potency of hematopoietic stem cells. Calming lysosomes reversed this process, opening avenues for new treatments [1]. Few
Nanoparticles Improve Intercellular Mitochondrial Transfer
November 24, 2025
Scientists have created “nanoflowers” that nudge donor cells to produce more mitochondria, which can then be transferred to recipient cells to boost their mitochondrial function [1]. Mitochondrial transfer is difficult
George Church on Building “Scientific Superintelligence”
November 21, 2025
George Church, a Harvard professor and a famed geroscientist, is also known as a serial entrepreneur who has co-founded dozens of biotech companies. While Church maintains that he’s involved in
How Senescent Cells Encourage Melanoma Growth
November 20, 2025
Researchers publishing in Aging Cell have documented a key reason why older people are much more likely to get melanoma. Why older people have significantly worse melanoma cases While melanoma
The Impact of Plant Polyphenols on Ovarian Aging
November 19, 2025
A recent review in the Journal of Ovarian Research summarizes current knowledge of the impact of various polyphenols on different aspects of ovarian aging. The researchers discuss that polyphenol supplementation
Improved Stem Cells Rejuvenate the Brains of Monkeys
November 18, 2025
Scientists have genetically modified human mesenchymal progenitor cells to express a more potent version of the “longevity gene” FOXO3, producing rejuvenative effects in monkeys, mice, and human cells [1]. Making
A Sarcopenia-Related MicroRNA May Help Pinpoint Its Origin
November 17, 2025
In Aging Cell, researchers have discovered a potential way to use a microRNA to diagnose sarcopenia, the age-related loss of muscle. Primary and secondary sarcopenia Previous research has been able
NAD+ Rescues Mouse Tauopathy by Fixing Alternative Splicing
November 14, 2025
A new study reveals a surprising mechanism that might be behind the beneficial effects of NAD+ in preclinical models of Alzheimer’s [1]. Which way to splice it? Not every part
The Key Questions of Longevity Research
November 13, 2025
In GeroScience, a large team of researchers, including João Pedro de Magalhães, has described a hundred currently unsolved problems in the field. Finding the right questions Understanding the fundamental nature
If Death Were Optional, Would You Still Choose It?
November 12, 2025
The idea of living longer, healthier lives thanks to rejuvenation biotechnology has steadily become more common. Gradually increasing numbers of articles are discussing this idea, especially as science is starting
Multilingualism Is Associated With Delayed Aging
November 12, 2025
A recent study of over 80,000 Europeans concluded that speaking more than one language is associated with delayed aging. Further analysis suggested that the protective effect of speaking one foreign
Rejuvenation Roundup November 2025
December 1, 2025
Many researchers in the United States have finished eating turkey and begun shopping, but their work continues. Here’s what people around the world have been doing to fight aging in November. Interviews George Church on Building “Scientific Superintelligence”: This involves creating an array of AI models
A Subtype of T Cells Counters Senescence in Mice
November 28, 2025
Scientists have discovered that a cytotoxic subtype of CD4 T cells, which is enriched in old people, helps control cellular senescence. This hints at a new type of anti-senescence strategy but also suggests that an immune system can be “overly youthful.” When generals become fighters CD4
An AI-Based System Has Found a Potential Longevity Drug
November 27, 2025
In a preprint published in bioRxiv, Prof. Vadim Gladyshev and a team of researchers have used an artificial intelligence-based system to discover a wide variety of potential interventions, including a drug that significantly improves biomarkers of frailty in mice. Repurposing previous data Previous research efforts have
The Roles of Phenylalanine and Tyrosine in Lifespan
November 26, 2025
A recent study investigated the impact of two amino acids, phenylalanine and tyrosine, on lifespan using UK Biobank data. The researchers reported an association between tyrosine and shorter lifespan, with sex-specific differences. The results for phenylalanine were more inconsistent [1]. One by one Model animal research
Fixing Lysosomes Improves Blood Stem Cell Function
November 25, 2025
In a recent study, scientists have demonstrated that lysosomal dysfunction actively decreases the potency of hematopoietic stem cells. Calming lysosomes reversed this process, opening avenues for new treatments [1]. Few and far between Hematopoietic stem cells (HSCs) are rare and precious: they produce blood progenitor cells,
Nanoparticles Improve Intercellular Mitochondrial Transfer
November 24, 2025
Scientists have created “nanoflowers” that nudge donor cells to produce more mitochondria, which can then be transferred to recipient cells to boost their mitochondrial function [1]. Mitochondrial transfer is difficult to improve Energy is required for life, and most energy in our cells is produced by
George Church on Building “Scientific Superintelligence”
November 21, 2025
George Church, a Harvard professor and a famed geroscientist, is also known as a serial entrepreneur who has co-founded dozens of biotech companies. While Church maintains that he’s involved in them all, one company has been seeing an unusual amount of his attention: Lila Sciences, where
How Senescent Cells Encourage Melanoma Growth
November 20, 2025
Researchers publishing in Aging Cell have documented a key reason why older people are much more likely to get melanoma. Why older people have significantly worse melanoma cases While melanoma is much more treatable now than in the past, it still remains a serious danger. Melanoma
The Impact of Plant Polyphenols on Ovarian Aging
November 19, 2025
A recent review in the Journal of Ovarian Research summarizes current knowledge of the impact of various polyphenols on different aspects of ovarian aging. The researchers discuss that polyphenol supplementation could be used as an intervention to delay ovarian aging [1]. Every woman’s problem Ovarian aging
Improved Stem Cells Rejuvenate the Brains of Monkeys
November 18, 2025
Scientists have genetically modified human mesenchymal progenitor cells to express a more potent version of the “longevity gene” FOXO3, producing rejuvenative effects in monkeys, mice, and human cells [1]. Making aging-resistant cells Stem cell exhaustion is one of the mechanisms of aging. Replenishing the aging stem
A Sarcopenia-Related MicroRNA May Help Pinpoint Its Origin
November 17, 2025
In Aging Cell, researchers have discovered a potential way to use a microRNA to diagnose sarcopenia, the age-related loss of muscle. Primary and secondary sarcopenia Previous research has been able to distinguish sarcopenia by its sources. Primary sarcopenia directly comes from the processes of aging, while
NAD+ Rescues Mouse Tauopathy by Fixing Alternative Splicing
November 14, 2025
A new study reveals a surprising mechanism that might be behind the beneficial effects of NAD+ in preclinical models of Alzheimer’s [1]. Which way to splice it? Not every part of a DNA sequence gets translated into a protein. Each sequence consists of exons, which are
The Key Questions of Longevity Research
November 13, 2025
In GeroScience, a large team of researchers, including João Pedro de Magalhães, has described a hundred currently unsolved problems in the field. Finding the right questions Understanding the fundamental nature of aging has been a problem since people first endeavored to live longer, to the point
If Death Were Optional, Would You Still Choose It?
November 12, 2025
The idea of living longer, healthier lives thanks to rejuvenation biotechnology has steadily become more common. Gradually increasing numbers of articles are discussing this idea, especially as science is starting to catch up and may eventually even deliver on it. With that in mind, I was
Multilingualism Is Associated With Delayed Aging
November 12, 2025
A recent study of over 80,000 Europeans concluded that speaking more than one language is associated with delayed aging. Further analysis suggested that the protective effect of speaking one foreign language diminished with age, while the protective effect of speaking two or more foreign languages was