Category: News
Uncovering a Predictive Biomarker for Alzheimer’s
April 20, 2023
Researchers publishing in Alzheimer’s and Dementia have published a correlation between the Alzheimer’s-linked protein tau and another protein, bisecting N-acetylglucosamine (GlcNAc), which suggests its usefulness as a biomarker. The need
Journal Club April 2023
April 20, 2023
In the Journal Club this month, we will be exploring a new study published in Nature Structural and Molecular Biology, where researchers demonstrated that by manipulating the DREAM protein complex,
Case Reports of Sclerotic Fibrosis in the Heart
April 19, 2023
A pair of case reports published in Heliyon have shed more light on the connection between systemic sclerosis and fatal heart failure, highlighting a need for early diagnosis and treatment.
Amyloid-β Clearance by the Liver Might Help with Alzheimer’s
April 19, 2023
Chinese scientists have found that the liver removes amyloid-β from circulation in mice, which also decreases its levels in the brain. The age-related impairment of this process might offer a
Rapamycin Rescues Age-Impaired Blood Flow in Mice
April 18, 2023
Scientists have concluded that rapamycin treatment started in early mid-life can prevent age-related blood flow impairment in the hindlimbs of wild-type, atherosclerotic, and Alzheimer’s model mice [1]. PAD and aging
Heart Organoids May Change Future Research
April 17, 2023
Researchers publishing in Nature Biotechnology have generated epicardioids, which are pluripotent, self-organizing stem cells that allow for better understanding, research, and potentially prevention and treatment of heart disease. A background
Review: Moderate Drinking Doesn’t Lower Mortality
April 17, 2023
A new comprehensive meta-analysis failed to find any protective effect of moderate drinking on mortality risk [1]. Linear or U-shaped? There is an ancient idea that while excessive drinking will
Comparing Mushroom and Animal Protein for Muscle Building
April 14, 2023
Scientists have reported that protein derived from mushrooms (mycoprotein) has a similar impact on muscle mass and strength as animal-based protein in young, healthy people undergoing resistance training [1]. Choosing
Longevity Prize Announces First Winners
April 13, 2023
The winners of the Hypothesis Prize have been announced as part of the Longevity Prize initiative. This is an important step for funding rejuvenation research and sets a great precedent
Age-Related Changes in RNA Transcription Speed
April 13, 2023
Research published yesterday in Nature has described one way in which RNA sequencing changes in the cell with age and how this may be linked to lifespan. Transcriptional elongation Transcriptional
Examining a Factor in the Diabetic Heart
April 12, 2023
Research published in Heliyon has outlined the effects of F-Klb, a signaling molecule receptor that is released under metabolic stress, on the hearts of diabetic patients. A protector that loses
Physical Activity, Sleeping, Sedentary Behavior, and Aging
April 12, 2023
Regular exercise, getting enough sleep, and avoiding sedentary behavior are frequently reported as being important in determining how slowly we age. A team of researchers recently set out to determine
Air Pollution Promotes Cancer Through Inflammation
April 11, 2023
Researchers have concluded that airborne fine particulate matter, which has been consistently linked to cancer, promotes lung cancer via inflammation and not necessarily via mutagenesis [1]. Not just mutations Common
Reducing Axonal Death and Inflammation in Mouse Brains
April 10, 2023
Researchers have published a study in Aging Cell on how inhibiting the death of axons in the brain protects the brains of old mice from inflammation. Necroptosis in the brain
Low Carb Intake Linked to Insulin Resistance
April 7, 2023
Scientists have published a new study where they suggest that low carbohydrate consumption is significantly associated with increased insulin resistance in healthy, lean people [1]. Benefits and risks Diet is
Uncovering a Predictive Biomarker for Alzheimer’s
April 20, 2023
Researchers publishing in Alzheimer’s and Dementia have published a correlation between the Alzheimer’s-linked protein tau and another protein, bisecting N-acetylglucosamine (GlcNAc), which suggests its usefulness as a biomarker. The need for early prediction This paper begins with a note that to be effective, Alzheimer’s treatment must
Journal Club April 2023
April 20, 2023
In the Journal Club this month, we will be exploring a new study published in Nature Structural and Molecular Biology, where researchers demonstrated that by manipulating the DREAM protein complex, a major regulator of DNA damage response, it may be possible to reduce the number of
Case Reports of Sclerotic Fibrosis in the Heart
April 19, 2023
A pair of case reports published in Heliyon have shed more light on the connection between systemic sclerosis and fatal heart failure, highlighting a need for early diagnosis and treatment. A systemic autoimmune disease Systemic sclerosis was once known as scleroderma, as the most visible signs
Amyloid-β Clearance by the Liver Might Help with Alzheimer’s
April 19, 2023
Chinese scientists have found that the liver removes amyloid-β from circulation in mice, which also decreases its levels in the brain. The age-related impairment of this process might offer a new clue for fighting Alzheimer’s disease [1]. The janitor of the body Despite the flop-laden history
Rapamycin Rescues Age-Impaired Blood Flow in Mice
April 18, 2023
Scientists have concluded that rapamycin treatment started in early mid-life can prevent age-related blood flow impairment in the hindlimbs of wild-type, atherosclerotic, and Alzheimer’s model mice [1]. PAD and aging Peripheral artery disease (PAD) is defined as reduced blood flow to the lower limbs. Age is
Heart Organoids May Change Future Research
April 17, 2023
Researchers publishing in Nature Biotechnology have generated epicardioids, which are pluripotent, self-organizing stem cells that allow for better understanding, research, and potentially prevention and treatment of heart disease. A background of heart development The epicardium, a layer of cells surrounding the heart, plays a major role
Review: Moderate Drinking Doesn’t Lower Mortality
April 17, 2023
A new comprehensive meta-analysis failed to find any protective effect of moderate drinking on mortality risk [1]. Linear or U-shaped? There is an ancient idea that while excessive drinking will kill you, moderate alcohol consumption is actually good for you, and until recently, it seemed to
Comparing Mushroom and Animal Protein for Muscle Building
April 14, 2023
Scientists have reported that protein derived from mushrooms (mycoprotein) has a similar impact on muscle mass and strength as animal-based protein in young, healthy people undergoing resistance training [1]. Choosing between animal and non-animal sources Proteins are essential for muscle building, and strong muscles are important
Longevity Prize Announces First Winners
April 13, 2023
The winners of the Hypothesis Prize have been announced as part of the Longevity Prize initiative. This is an important step for funding rejuvenation research and sets a great precedent for future longevity-focused prizes and open science. Introducing the Longevity Prize The Longevity Prize is a
Age-Related Changes in RNA Transcription Speed
April 13, 2023
Research published yesterday in Nature has described one way in which RNA sequencing changes in the cell with age and how this may be linked to lifespan. Transcriptional elongation Transcriptional elongation is a fundamental biological process, as it affects the basic steps involved in the production
Examining a Factor in the Diabetic Heart
April 12, 2023
Research published in Heliyon has outlined the effects of F-Klb, a signaling molecule receptor that is released under metabolic stress, on the hearts of diabetic patients. A protector that loses its effectiveness Fibroblast growth factor 21 (FGF21) is a regulator of metabolism that is produced both
Physical Activity, Sleeping, Sedentary Behavior, and Aging
April 12, 2023
Regular exercise, getting enough sleep, and avoiding sedentary behavior are frequently reported as being important in determining how slowly we age. A team of researchers recently set out to determine the link between physical activity, sleeping, and sedentary behavior [1]. Finding out if sleep, exercise, and
Air Pollution Promotes Cancer Through Inflammation
April 11, 2023
Researchers have concluded that airborne fine particulate matter, which has been consistently linked to cancer, promotes lung cancer via inflammation and not necessarily via mutagenesis [1]. Not just mutations Common wisdom says that carcinogens increase cancer risk mostly by promoting oncogenic mutations. Research has reported that
Reducing Axonal Death and Inflammation in Mouse Brains
April 10, 2023
Researchers have published a study in Aging Cell on how inhibiting the death of axons in the brain protects the brains of old mice from inflammation. Necroptosis in the brain It is well-known that aged organisms have problems with cognitive function, and this is strongly linked
Low Carb Intake Linked to Insulin Resistance
April 7, 2023
Scientists have published a new study where they suggest that low carbohydrate consumption is significantly associated with increased insulin resistance in healthy, lean people [1]. Benefits and risks Diet is a powerful mediator of health and longevity. While there is broad consensus on what dietary components