Lifespan Research Institute

Category: News

Sniffing mouse

How NAD+ Relates to Smell Loss with Age

Researchers publishing in Aging Cell have elucidated a relationship between aging, the loss of smell, and NAD+ in a mouse model. Olfactory ability declines with age Roughly half of people

Leadership

Insider Insight: Meet the Organizers of LongHack

LongHack, the longevity hackathon hosted by DeSci organization VitaDAO, was held on January 20th-23rd, 2023. Gathering researchers, developers, and other interested parties to create new tools and solutions for longevity,

Rejuvenation Roundup February

Rejuvenation Roundup February 2023

We continue to grow as an organization and in readership, but the fight against aging is far from over. Here’s what’s been done in February. Lifespan.io News Team and activities

Matthew O'Connor Interview

Ending Atherosclerosis: Cyclarity and Dr. Matthew O’Connor

Cyclarity Therapeutics is striving to make powerful treatments for cardiovascular disease and, most importantly, make them accessible and affordable. Their cutting-edge cyclodextrin technology targets atherosclerosis, aiming to eliminate the buildup

NOVOS logo

Chris Mirabile on the NOVOS Approach

With multiple experts on its scientific advisory board, NOVOS offers supplements containing ingredients that recent research has linked to longevity. This company also markets biological age tests for people who

Advanced clock

Nonlinear Analysis for a Better Epigenetic Clock

A team publishing in Human Genomics has developed a new model for analyzing epigenetic changes that uses nonlinear analysis. Current clocks are linear Current epigenetic clocks, including the original Horvath

Brain tumor

Senescent Cells Contribute to Brain Cancer

Combining results from human tumors and a mouse model, researchers publishing in Nature Communications have shown that senescent cells promote the growth of glioblastoma, a form of brain cancer. Deadly,

Protein muscle

High Protein Intake Associated With Sarcopenia

Researchers publishing in Age and Ageing have found that, rather than being protective, an increase in dietary protein is associated with an increased chance of sarcopenia. Sarcopenia is a well-known

Sniffing mouse

How NAD+ Relates to Smell Loss with Age

Researchers publishing in Aging Cell have elucidated a relationship between aging, the loss of smell, and NAD+ in a mouse model. Olfactory ability declines with age Roughly half of people over the age of 65 experience a decreased ability to smell [1], and research has shown

Tzipi Strauss

Prof. Tzipi Strauss on the Upcoming Longevity Center

Despite its small size, Israel is packing quite a punch when it comes to innovation, having earned the moniker “the startup nation”. It also has advanced healthcare and some of the best hospitals in the world. In one of them, Sheba Medical Center, the first-of-its-kind Longevity

Leadership

Insider Insight: Meet the Organizers of LongHack

LongHack, the longevity hackathon hosted by DeSci organization VitaDAO, was held on January 20th-23rd, 2023. Gathering researchers, developers, and other interested parties to create new tools and solutions for longevity, ten teams competed to impress the judging panel and take home prizes: 5,500 VITA and 3,500

Exercise and supplements

Exercise and Supplements Against Age-Related Inflammation

In a new systematic review, researchers have shown that combining some dietary supplements and exercise might be beneficial for people over the age of 60 [1]. A double-edged sword Chronic low-level inflammation accompanies many hereditary and age-associated diseases. Inflammation also plays an important role in ‘healthy’

Obesity and time

Association Between BMI and Mortality Revisited

In a new paper, Ryan K. Masters, professor at CU Boulder, suggests that when adjusted for body shape and lifelong shifts, the relationship between BMI and mortality is more linear and robust than previously thought, with normal BMI being the healthiest [1]. BMI’s many problems Most

Rejuvenation Roundup February

Rejuvenation Roundup February 2023

We continue to grow as an organization and in readership, but the fight against aging is far from over. Here’s what’s been done in February. Lifespan.io News Team and activities Our Organization Grows to Support Rejuvenation Research: Spring is not far away here in the Northern

Matthew O'Connor Interview

Ending Atherosclerosis: Cyclarity and Dr. Matthew O’Connor

Cyclarity Therapeutics is striving to make powerful treatments for cardiovascular disease and, most importantly, make them accessible and affordable. Their cutting-edge cyclodextrin technology targets atherosclerosis, aiming to eliminate the buildup of non-degradable oxidized cholesterol that gets stuck inside cells in the arterial walls. The company has

NOVOS logo

Chris Mirabile on the NOVOS Approach

With multiple experts on its scientific advisory board, NOVOS offers supplements containing ingredients that recent research has linked to longevity. This company also markets biological age tests for people who want to monitor their progress. We spoke with NOVOS founder and CEO Chris Mirabile about the

Advanced clock

Nonlinear Analysis for a Better Epigenetic Clock

A team publishing in Human Genomics has developed a new model for analyzing epigenetic changes that uses nonlinear analysis. Current clocks are linear Current epigenetic clocks, including the original Horvath clock and the death-predicting GrimAge, use linear analyses of methylation sites to estimate biological age. However,

Brain tumor

Senescent Cells Contribute to Brain Cancer

Combining results from human tumors and a mouse model, researchers publishing in Nature Communications have shown that senescent cells promote the growth of glioblastoma, a form of brain cancer. Deadly, aggressive, and hard to treat Glioblastoma is one of the most dangerous forms of cancer. Even

Genetic erasure

Removal of Neuronal APOE4 Alleviates Alzheimer’s in Mice

In a new study published in Nature Aging, scientists have shown that targeted ablation of neuronal APOE4, which produces the ApoE4 protein, significantly protects against Alzheimer’s disease in a mouse model [1]. The dreadful allele An infamous variant of the APOE gene, APOE4, is the strongest

Cell manufacturing

The State of the Art in Immune Cell Therapy

A pair of researchers from Stanford University have published a detailed review of the current state of CAR T immune cell therapies in Nature. A new state of the art in fighting cancer Chimeric antigen receptor (CAR) is a technology that allows researchers to alter T

Food clock

Caloric Restriction Might Slow Down Human Aging

In a paper published in Nature Aging, researchers have shown that caloric restriction modestly slows down the pace of aging in healthy young people as measured by one of the DNA methylation clocks [1]. CALERIE design A plethora of animal data has shown beneficial effects of

Protein muscle

High Protein Intake Associated With Sarcopenia

Researchers publishing in Age and Ageing have found that, rather than being protective, an increase in dietary protein is associated with an increased chance of sarcopenia. Sarcopenia is a well-known disorder that occurs with aging. People with sarcopenia lack adequate muscular function, leading to frailty, a

Lifespan.io Editorial

Our Organization Grows to Support Rejuvenation Research

Spring is not far away here in the Northern Hemisphere, and with it, the signs of life and new growth are appearing. Much like the change of seasons, our organization is also growing and preparing to continue the fight against age-related diseases. Matt Kaeberlein joins our