Category: News
New Gene Therapy Robustly Lowers LDL and Triglycerides
November 11, 2025
A new Phase 1 trial produced encouraging safety and efficacy results for a CRISPR-based gene therapy that silences a gene important for lipid regulation. This therapy might increase adherence and
High-Fiber Foods May Fight T Cell Senescence
November 10, 2025
Researchers have discovered that butyrate, a short-chain fatty acid with well-documented gut benefits, fights senescence in T cells. Immune senescence drives inflammaging Senescence of the immune system (immunosenescence) is a
Mice With Reduced Astrocytic Oxidative Stress Live Longer
November 7, 2025
Scientists have discovered that directly reducing the production of reactive oxygen species (ROS) at their source in astrocytes, mitochondrial complex III, improves neuronal health and significantly increases lifespan in a
EDA2R May Be an Aging Biomarker and Inflammaging Target
November 6, 2025
A review in Aging Cell has cataloged the harmful effects of EDA2R, a protein that affects three distinct inflammation-related pathways. A necessary protein gone bad Like nearly every other protein
Rapamycin May Delay Age-Related Fertility Decline
November 5, 2025
In a recent study, researchers identified that an increase in the expression of ribosome-related genes and a loss of protein homeostasis contribute to the age-related decline in female fertility. Rapamycin
Skin Aging Underlined by Loss of Capillary Macrophages
November 4, 2025
A new study ties the disappearance of capillary-associated macrophages to age-related vascular degeneration in the skin. Boosting their function with a growth factor offers a possible avenue for anti-aging interventions
Rejuvenation Roundup October 2025
November 3, 2025
The trick-or-treaters have all gone home as the leaves have fallen to the ground, but rejuvenation biotech attempts to prevent human beings from fading away. Here’s what’s been done to
Men Might Need More Exercise to Lower Cardiovascular Risks
October 31, 2025
A new observational study suggests that men need more than twice as much exercise as women do to achieve the same level of reduction in the risk of cardiovascular heart
Maintenance Stays Efficient in Healthy Older People’s Cells
October 30, 2025
Researchers publishing in Aging Cell have found that the efficiency of autophagy, a cellular maintenance process, increases rather than decreases in some T cells derived from healthy older people. Keeping
Organ Fat Is Associated With Carotid Atherosclerosis
October 29, 2025
A recent study discovered an association between visceral and, to a lesser extent, hepatic fat with cardiovascular risk factors and carotid atherosclerosis. This association persists even after adjusting for cardiovascular
Review Links Lingering Infections to Senescence
October 28, 2025
In a comprehensive review, scientists discuss the various mechanisms by which chronic infections drive cellular senescence and aging [1]. Lurking in the body People are mostly aware of acute infections,
Stiff Collagen May Lead to Senescent Cells
October 27, 2025
A preprint study has found that the stiffness of the extracellular matrix (ECM) itself encourages cells to undergo senescence. An unexplored relationship ECM stiffness and cellular senescence are both well-known
Amyloid-Fibrinogen Complexes Exacerbate Alzheimer’s in Mice
October 24, 2025
A study from Rockefeller University suggests that an unholy duo of two proteins causes harm in much lower concentrations than either of them alone. This points to a possible route
Measuring Dog Aging With Protein Metabolism
October 23, 2025
Researchers working with data from the Dog Aging Project have found that post-translationally modified amino acids (ptmAAs), which are generated from protein metabolism, are useful in determining the biological ages
Andrea Maier on Longevity Medicine for All
October 22, 2025
Dr. Andrea Maier, Oon Chiew Seng Professor in Medicine at the National University of Singapore, is a veteran geroscientist and one of the most familiar faces in the rising field
New Gene Therapy Robustly Lowers LDL and Triglycerides
November 11, 2025
A new Phase 1 trial produced encouraging safety and efficacy results for a CRISPR-based gene therapy that silences a gene important for lipid regulation. This therapy might increase adherence and reduce side effects [1]. Addressing the adherence problem High levels of LDL cholesterol (LDL-C) and triglycerides
High-Fiber Foods May Fight T Cell Senescence
November 10, 2025
Researchers have discovered that butyrate, a short-chain fatty acid with well-documented gut benefits, fights senescence in T cells. Immune senescence drives inflammaging Senescence of the immune system (immunosenescence) is a problem that drives many others. In particular, T cells are known to secrete inflammatory SASP compounds
Mice With Reduced Astrocytic Oxidative Stress Live Longer
November 7, 2025
Scientists have discovered that directly reducing the production of reactive oxygen species (ROS) at their source in astrocytes, mitochondrial complex III, improves neuronal health and significantly increases lifespan in a mouse model of Alzheimer’s [1]. Dangerous species Reactive oxygen species (ROS) are short-lived, highly reactive oxygen-containing
EDA2R May Be an Aging Biomarker and Inflammaging Target
November 6, 2025
A review in Aging Cell has cataloged the harmful effects of EDA2R, a protein that affects three distinct inflammation-related pathways. A necessary protein gone bad Like nearly every other protein with documented harmful effects, this one is required for certain systems to function properly. The EDA
Rapamycin May Delay Age-Related Fertility Decline
November 5, 2025
In a recent study, researchers identified that an increase in the expression of ribosome-related genes and a loss of protein homeostasis contribute to the age-related decline in female fertility. Rapamycin restored this balance and increased fertility rates in a human trial [1]. The first system to
Skin Aging Underlined by Loss of Capillary Macrophages
November 4, 2025
A new study ties the disappearance of capillary-associated macrophages to age-related vascular degeneration in the skin. Boosting their function with a growth factor offers a possible avenue for anti-aging interventions [1]. Macrophages, capillaries, and skin aging Skin aging might not be the most dangerous aspect of
Rejuvenation Roundup October 2025
November 3, 2025
The trick-or-treaters have all gone home as the leaves have fallen to the ground, but rejuvenation biotech attempts to prevent human beings from fading away. Here’s what’s been done to fight aging in October. Team and activities Our Campaign for Public Longevity: Public trust is the
Men Might Need More Exercise to Lower Cardiovascular Risks
October 31, 2025
A new observational study suggests that men need more than twice as much exercise as women do to achieve the same level of reduction in the risk of cardiovascular heart disease [1]. Understanding sex differences In recent years, scientists have questioned how much exercise is needed
Maintenance Stays Efficient in Healthy Older People’s Cells
October 30, 2025
Researchers publishing in Aging Cell have found that the efficiency of autophagy, a cellular maintenance process, increases rather than decreases in some T cells derived from healthy older people. Keeping cells healthy The researchers introduce their paper by discussing autophagy and its decline in aging. They
Organ Fat Is Associated With Carotid Atherosclerosis
October 29, 2025
A recent study discovered an association between visceral and, to a lesser extent, hepatic fat with cardiovascular risk factors and carotid atherosclerosis. This association persists even after adjusting for cardiovascular risk factors [1]. Beyond BMI Body mass index (BMI) is a metric that compares height to
Review Links Lingering Infections to Senescence
October 28, 2025
In a comprehensive review, scientists discuss the various mechanisms by which chronic infections drive cellular senescence and aging [1]. Lurking in the body People are mostly aware of acute infections, such as the common cold, COVID-19, and malaria. Science has made great strides against these kinds
Stiff Collagen May Lead to Senescent Cells
October 27, 2025
A preprint study has found that the stiffness of the extracellular matrix (ECM) itself encourages cells to undergo senescence. An unexplored relationship ECM stiffness and cellular senescence are both well-known aspects of aging. The cross-linked collagens, such as glucosepane, that lead to a less-flexible ECM accumulate
Amyloid-Fibrinogen Complexes Exacerbate Alzheimer’s in Mice
October 24, 2025
A study from Rockefeller University suggests that an unholy duo of two proteins causes harm in much lower concentrations than either of them alone. This points to a possible route for intervention [1]. When amyloid met fibrinogen Amyloid beta (Aβ) and tau proteins are the usual
Measuring Dog Aging With Protein Metabolism
October 23, 2025
Researchers working with data from the Dog Aging Project have found that post-translationally modified amino acids (ptmAAs), which are generated from protein metabolism, are useful in determining the biological ages of dogs. The Dog Aging Project With enrollment beginning in 2020, the Dog Aging Project (DAP)
Andrea Maier on Longevity Medicine for All
October 22, 2025
Dr. Andrea Maier, Oon Chiew Seng Professor in Medicine at the National University of Singapore, is a veteran geroscientist and one of the most familiar faces in the rising field of longevity medicine, which aims to translate the early successes of geroscience into clinical practice. Parallel