Category: News
Silly Walking for Serious Exercise
January 6, 2023
Researchers have shown that a particular walking style that many people immediately recognize can count as high-intensity exercise [1]. Does exercise have to be boring? In the fight against aging,
Targeting Cdc42 Improves Stem Cells in Old Mice
January 5, 2023
Researchers publishing in the Nature journal npj Regenerative Medicine have zeroed in on a major reason behind stem cell exhaustion and determined that inhibiting it has significantly rejuvenative effects. A
Senescent Cells Harm Muscle Regeneration in Mice
January 4, 2023
New research published in Nature has shown that senescent cells hamper muscle regeneration through inflammation and fibrosis [1]. Cellular senescence is one of the hallmarks of aging. However, there is
Novel Longevity Gene Variants Identified in Centenarians
January 4, 2023
In a study published in International Journal of Molecular Sciences, a team of researchers known for their studies on long-lived individuals has discovered four new genetic loci that partially explain
Emma Teeling on What We Can Learn from Bats
January 3, 2023
Emma Teeling is a professor at University College of Dublin, and her research focuses on bats. In this interview, Emma explains why many bats, despite having tiny body sizes and
Rejuvenation Roundup December 2022
January 3, 2023
The holiday season is over, the new year is upon us, and we return to our mission of giving us many more years to come. Here’s what’s been done on
Changes To The Lamina Contribute To Heart Weakness
December 22, 2022
A paper just published in Nature Aging has explained how changes to the lamina contribute to heart weakness in model organisms. A protective enclosure for genetic stability Lamin proteins enclose
Transcriptome-Wide Organization Changes in Aging
December 21, 2022
In a new study published in Nature Aging, researchers have shown that aging is associated with a decreased expression of long transcripts over multiple tissues across several animal species [1].
Fighting Osteoporosis Through Cellular Signaling
December 19, 2022
A paper published in Experimental Gerontology has detailed how a bacterially derived compound may be useful in fighting osteoporosis. Osteoblasts and osteoclasts Osteoblasts are cells that build bone, and osteoclasts
Short Bouts of Vigorous Activity May Reduce Mortality Risk
December 16, 2022
In a study published in Nature Medicine, scientists have shown that short bouts of everyday vigorous physical activity, such as stair climbing, are associated with a considerable reduction in mortality
Phytocannabinoids and Skin Rejuvenation
December 16, 2022
The Journal Club returns for the last time this year at 12:00 Eastern on Tuesday 20th on the Lifespan.io Facebook page. This month, Dr. Oliver Medvedik is taking a look
Exploring Autophagy to Fight AMD
December 15, 2022
Publishing in Free Radical Biology and Medicine, a team of Chinese researchers has investigated the potential role of autophagy in fighting oxidative stress and potentially staving off age-related macular degeneration
Size Matters in Cellular Aging
December 14, 2022
In a new review article published in Frontiers in Cell and Developmental Biology, researchers have suggested adding cellular enlargement to the hallmarks of aging [1]. Bigger is not always better
Study Suggests NMN May Improve NAD+ and Walking Speed
December 13, 2022
A new study suggests that NMN supplementation elevates NAD+ levels and increases walking distance in healthy participants, with 600 mg/day being the optimal dose [1]. NAD+ and its precursors While
Genetically Enhancing T Cells to Fight Tumors
December 12, 2022
A team of researchers from multiple Japanese universities has found a way to genetically enhance T cells against solid tumors, as published today in Nature Biomedical Engineering. A focus on
Silly Walking for Serious Exercise
January 6, 2023
Researchers have shown that a particular walking style that many people immediately recognize can count as high-intensity exercise [1]. Does exercise have to be boring? In the fight against aging, anything goes. As we have reported numerous times, exercise is one of the most effective anti-aging
Targeting Cdc42 Improves Stem Cells in Old Mice
January 5, 2023
Researchers publishing in the Nature journal npj Regenerative Medicine have zeroed in on a major reason behind stem cell exhaustion and determined that inhibiting it has significantly rejuvenative effects. A protein that suppresses stem cells In both humans and mice, the protein Cdc42 increases with aging.
Senescent Cells Harm Muscle Regeneration in Mice
January 4, 2023
New research published in Nature has shown that senescent cells hamper muscle regeneration through inflammation and fibrosis [1]. Cellular senescence is one of the hallmarks of aging. However, there is a growing understanding that, just like aging itself, senescence is a complex and heterogeneous phenomenon [2].
Novel Longevity Gene Variants Identified in Centenarians
January 4, 2023
In a study published in International Journal of Molecular Sciences, a team of researchers known for their studies on long-lived individuals has discovered four new genetic loci that partially explain extreme longevity [1]. Genetics can be friend or foe Centenarians are people who have lived for
Emma Teeling on What We Can Learn from Bats
January 3, 2023
Emma Teeling is a professor at University College of Dublin, and her research focuses on bats. In this interview, Emma explains why many bats, despite having tiny body sizes and leading very metabolically demanding lifestyles, are so amazingly long-lived. Will we ever be able to learn
Rejuvenation Roundup December 2022
January 3, 2023
The holiday season is over, the new year is upon us, and we return to our mission of giving us many more years to come. Here’s what’s been done on the rejuvenation front last month. LEAF News Team and activities Wishing You a Happy Holiday and
Changes To The Lamina Contribute To Heart Weakness
December 22, 2022
A paper just published in Nature Aging has explained how changes to the lamina contribute to heart weakness in model organisms. A protective enclosure for genetic stability Lamin proteins enclose the nucleus in the lamina, the cellular envelope that contains and protects DNA. In progeria, a
Transcriptome-Wide Organization Changes in Aging
December 21, 2022
In a new study published in Nature Aging, researchers have shown that aging is associated with a decreased expression of long transcripts over multiple tissues across several animal species [1]. Global changes It is well known that aging is accompanied by changes in the expression of
Fighting Osteoporosis Through Cellular Signaling
December 19, 2022
A paper published in Experimental Gerontology has detailed how a bacterially derived compound may be useful in fighting osteoporosis. Osteoblasts and osteoclasts Osteoblasts are cells that build bone, and osteoclasts are cells that consume it. These two processes happen consistently and naturally in the human body.
Short Bouts of Vigorous Activity May Reduce Mortality Risk
December 16, 2022
In a study published in Nature Medicine, scientists have shown that short bouts of everyday vigorous physical activity, such as stair climbing, are associated with a considerable reduction in mortality risk, especially in cardiovascular mortality [1]. Everyday activities and health Exercise is one of the most
Phytocannabinoids and Skin Rejuvenation
December 16, 2022
The Journal Club returns for the last time this year at 12:00 Eastern on Tuesday 20th on the Lifespan.io Facebook page. This month, Dr. Oliver Medvedik is taking a look at a new paper that explores phytocannabinoids in the context of skin aging and rejuvenation. Phytocannabinoids
Exploring Autophagy to Fight AMD
December 15, 2022
Publishing in Free Radical Biology and Medicine, a team of Chinese researchers has investigated the potential role of autophagy in fighting oxidative stress and potentially staving off age-related macular degeneration (AMD). AMD, oxidative stress, and autophagy AMD comes in two major forms. In the nonexudative (dry)
Size Matters in Cellular Aging
December 14, 2022
In a new review article published in Frontiers in Cell and Developmental Biology, researchers have suggested adding cellular enlargement to the hallmarks of aging [1]. Bigger is not always better Different cell types are known to have different shapes and sizes, which are dictated by their
Study Suggests NMN May Improve NAD+ and Walking Speed
December 13, 2022
A new study suggests that NMN supplementation elevates NAD+ levels and increases walking distance in healthy participants, with 600 mg/day being the optimal dose [1]. NAD+ and its precursors While NAD+ can be supplemented via precursors such as NMN, this route has a few roadblocks as
Genetically Enhancing T Cells to Fight Tumors
December 12, 2022
A team of researchers from multiple Japanese universities has found a way to genetically enhance T cells against solid tumors, as published today in Nature Biomedical Engineering. A focus on signals This highly in-depth paper begins with a discussion of signaling in the response of chimeric