Category: News
The Role of Mitochondrial Antioxidants in Longevity
May 19, 2022
A study published in Redox Biology has reported that the upregulation of thioredoxin, a fundamental part of mitochondrial defense against reactive oxygen species, is associated with longevity in mutant C.
Reprogramming Cells with Vittorio Sebastiano of Turn.bio
May 19, 2022
Vittorio Sebastiano is an Associate Professor (Research) of Obstetrics and Gynecology at Stanford University and one of the most prominent scientists in the emerging field of cellular reprogramming. He is
FOXM1 Induction Extends Lifespan in Mice
May 18, 2022
In a new study published in Nature Aging, researchers have shown that inducing a truncated FOXM1 gene extends lifespan in both progeric and naturally aging mice [1]. FOXO genes and
Discussing Crowd Funded Cures with Savva Kerdemelidis
May 17, 2022
We have written extensively about VitaDAO, a collective dedicated to community-governed, decentralized drug development. Probably the fastest and cheapest way to get geroprotective drugs to the market is by repurposing
Caloric Restriction, Feeding Times Lengthen Mouse Lifespan
May 17, 2022
In a new study published in Science, researchers show that caloric restriction and time-restricted feeding have an additive effect on lifespan in mice [1]. A well-known intervention Caloric restriction is
The Development of Glowing Pluripotent Cells
May 16, 2022
A team of Chinese researchers has described a novel method of illuminating pluripotent stem cells in a paper published in Aging. How and why Using a lentivirus, the researchers genetically
João Pedro de Magalhães on Reprogramming and Aging Theories
May 13, 2022
Professor João Pedro de Magalhães leads the Genomics of Ageing and Rejuvenation Lab at the Institute of Inflammation and Ageing in the University of Birmingham. He is also CSO of
Using an Endemic Virus as a Gene Therapy for Life Extension
May 12, 2022
In a study printed in PNAS, researchers have shown that telomerase reverse transcriptase (TERT) can be given to cells in living mice through a viral vector, taking the idea of
Walking Pace Correlated with Increased Telomere Length
May 11, 2022
Publishing in Nature Communications, Dr. Tom Yate, Dr. Neliesh J. Samani, and colleagues used data from approximately 400,000 people in the UK Biobank in order to examine the relationship between
Drug Cocktail Delays Aging in Mice
May 10, 2022
Scientists have shown that a combination of rapamycin, acarbose, and phenylbutyrate has a synergetic rejuvenation effect when administered to 20-month-old mice for three months [1]. Fighting on multiple fronts In
NMN Boosts Effectiveness of Immunotherapy in Mice
May 10, 2022
In a pre-print paper, scientists have shown that treatment with NMN increases the survival and anti-cancer efficacy of CAR-T cells [1]. The problem with immunotherapy T cells are a central
The Gut Microbiome Affects the Brain, Eyes, and Gut in Mice
May 9, 2022
Publishing in Microbiome, a team of researchers has ascertained multiple physical effects of aging gut flora in mice. Antibiotics and fecal transfers The researchers used three groups of mice: young
Cannabidiol Increases Lifespan and Healthspan in Worms
May 6, 2022
Scientists have shown that an active ingredient of cannabis significantly upregulates autophagy, extending both lifespan and healthspan in C. elegans nematode worms. Two of the most well-known components of marijuana
Why The Skin of Naked Mole Rats Ages Slowly
May 5, 2022
A study published in Aging has shown that the skin of the naked mole rat retains nearly all of its physical and biochemical properties as these animals chronologically age, providing
Prof. Richard Miller on the Interventions Testing Program
May 5, 2022
Richard A. Miller is a Professor of Pathology at the University of Michigan and the Director of Michigan’s Paul F. Glenn Center for Biology of Aging Research. He is also
The Role of Mitochondrial Antioxidants in Longevity
May 19, 2022
A study published in Redox Biology has reported that the upregulation of thioredoxin, a fundamental part of mitochondrial defense against reactive oxygen species, is associated with longevity in mutant C. elegans worms. Free radicals, revisited The free radical theory of aging, which focuses on reactive oxygen
Reprogramming Cells with Vittorio Sebastiano of Turn.bio
May 19, 2022
Vittorio Sebastiano is an Associate Professor (Research) of Obstetrics and Gynecology at Stanford University and one of the most prominent scientists in the emerging field of cellular reprogramming. He is also co-founder and Scientific Advisory Board Chairman of Turn Biotechnologies, a cellular rejuvenation company based on
FOXM1 Induction Extends Lifespan in Mice
May 18, 2022
In a new study published in Nature Aging, researchers have shown that inducing a truncated FOXM1 gene extends lifespan in both progeric and naturally aging mice [1]. FOXO genes and longevity Forkhead box (FOX) genes are transcription factors: genes that drive the expression of other genes
Discussing Crowd Funded Cures with Savva Kerdemelidis
May 17, 2022
We have written extensively about VitaDAO, a collective dedicated to community-governed, decentralized drug development. Probably the fastest and cheapest way to get geroprotective drugs to the market is by repurposing existing drugs, such as rapamycin, metformin, and acarbose. These drugs cost next to nothing, have a
Caloric Restriction, Feeding Times Lengthen Mouse Lifespan
May 17, 2022
In a new study published in Science, researchers show that caloric restriction and time-restricted feeding have an additive effect on lifespan in mice [1]. A well-known intervention Caloric restriction is considered the first intervention to reliably show that aging is a malleable phenomenon. The first trials
The Development of Glowing Pluripotent Cells
May 16, 2022
A team of Chinese researchers has described a novel method of illuminating pluripotent stem cells in a paper published in Aging. How and why Using a lentivirus, the researchers genetically engineered mouse embryos to express green fluorescent protein (GFP) when it expresses the Yamanaka factor Oct4.
João Pedro de Magalhães on Reprogramming and Aging Theories
May 13, 2022
Professor João Pedro de Magalhães leads the Genomics of Ageing and Rejuvenation Lab at the Institute of Inflammation and Ageing in the University of Birmingham. He is also CSO of YouthBio Therapeutics, a US-based biotech company that develops rejuvenation gene therapies based on partial reprogramming by
Using an Endemic Virus as a Gene Therapy for Life Extension
May 12, 2022
In a study printed in PNAS, researchers have shown that telomerase reverse transcriptase (TERT) can be given to cells in living mice through a viral vector, taking the idea of life-extending gene therapies from science fiction to reality. Why a cytomegalovirus? The human cytomegalovirus (CMV) is
Walking Pace Correlated with Increased Telomere Length
May 11, 2022
Publishing in Nature Communications, Dr. Tom Yate, Dr. Neliesh J. Samani, and colleagues used data from approximately 400,000 people in the UK Biobank in order to examine the relationship between walking pace and telomere length. Previous evidence suggests that increased physical activity and cardiorespiratory fitness is
Drug Cocktail Delays Aging in Mice
May 10, 2022
Scientists have shown that a combination of rapamycin, acarbose, and phenylbutyrate has a synergetic rejuvenation effect when administered to 20-month-old mice for three months [1]. Fighting on multiple fronts In this paper, the authors argue that to tackle such a multifaced process as aging, it might
NMN Boosts Effectiveness of Immunotherapy in Mice
May 10, 2022
In a pre-print paper, scientists have shown that treatment with NMN increases the survival and anti-cancer efficacy of CAR-T cells [1]. The problem with immunotherapy T cells are a central element of the adaptive immune system, and some of them can be cytotoxic: they have the
The Gut Microbiome Affects the Brain, Eyes, and Gut in Mice
May 9, 2022
Publishing in Microbiome, a team of researchers has ascertained multiple physical effects of aging gut flora in mice. Antibiotics and fecal transfers The researchers used three groups of mice: young (3 months), old (18 months), and aged (24 months). Young and old groups were divided into
Cannabidiol Increases Lifespan and Healthspan in Worms
May 6, 2022
Scientists have shown that an active ingredient of cannabis significantly upregulates autophagy, extending both lifespan and healthspan in C. elegans nematode worms. Two of the most well-known components of marijuana are tetrahydrocannabinol (THC) and cannabidiol (CBD). They have the same atomic composition, but differ in structure
Why The Skin of Naked Mole Rats Ages Slowly
May 5, 2022
A study published in Aging has shown that the skin of the naked mole rat retains nearly all of its physical and biochemical properties as these animals chronologically age, providing new insight into how and why these animals live so long. Wrinkly, but not like humans
Prof. Richard Miller on the Interventions Testing Program
May 5, 2022
Richard A. Miller is a Professor of Pathology at the University of Michigan and the Director of Michigan’s Paul F. Glenn Center for Biology of Aging Research. He is also a driving force behind the ITP, the Interventions Testing Program, created in the early 2000s to