Category: News
Urolithin A Improves Muscle Strength in Middle-Aged Adults
June 10, 2022
A new study published in Cell Reports Medicine shows that urolithin A supplementation improves muscle strength, fitness, and mitochondrial health in overweight, middle-aged adults [1]. Mitophagy in aging and in
Drug Leads to Drastic Weight Loss With Diet and Exercise
June 9, 2022
A large Phase 3 study published in the New England Journal of Medicine shows that an existing drug combined with a healthy diet and mild exercise leads to an average
Spermidine Human Trial Results Fail to Impress
June 8, 2022
The results of a human clinical trial for spermidine against cognitive decline have recently been published, but the results are not positive. What is spermidine? Spermidine is a polyamine, meaning
Antibody Therapy Alone Eliminates Certain Rectal Cancers
June 7, 2022
Researchers publishing in the New England Journal of Medicine have been able to completely eliminate stage 2 and 3 rectal tumors with a single monoclonal antibody drug [1]. Therapy comes
Senolytic Interventions Ameliorate Radiation Damage in Mice
June 6, 2022
In their publication in eLife Sciences, researchers at Newcastle University in the UK have illustrated how radiation-induced damage can be somewhat ameliorated with senolytics. These researchers focused on navitoclax along
Modifiying Retrons for Better Gene Editing
June 3, 2022
A new study published in Nature Chemical Biology has described an advancement in the use of retrons, a novel method of genetic engineering that may become superior to CRISPR technology.
NMN Human Trial Results Published
June 2, 2022
The data from a multicenter NMN clinical trial have been published with some very modest but still interesting results [1]. What is NMN? NMN is short for nicotinamide mononucleotide, a
Fighting Alzheimer’s Disease with Increased Autophagy
June 1, 2022
In a new study published in Pharmacology Biochemistry and Behavior, researchers have shown that a combination of two compounds targeting different autophagy pathways is effective in fighting the pathological mechanism
Rejuvenation Roundup May 2022
June 1, 2022
Two days ago, the United States honored its fallen veterans. How many of those heroes came home, having survived the horrors of war, only to have their own bodies betray
Not All Hallmarks of Aging Contribute to Epigenetic Age
May 31, 2022
Scientists have shown that only some of the hallmarks of aging affect methylation clocks that are used to measure biological age [1]. The big black box Epigenetic clocks that measure
Chloroquine Increases Lifespan in Male Mice
May 30, 2022
Researchers publishing in Aging have found that the anti-malarial drug chloroquine increases lifespan in male NRMI mice. The NRMI, like the Black 6, is a standard breed widely used in
Plasmalogens Alleviate Age-Related Cognitive Decline in Mice
May 27, 2022
Scientists have learned that plasmalogens, obscure but important lipids, serve as a mediator of neurogenesis and synaptic health and can reverse age-related cognitive decline in mice [1]. Plasmalogens and membranes
Visually Identifying Senescent Cells with an Algorithm
May 26, 2022
A team of researchers publishing in Aging has developed a method of identifying senescent cells through their physical morphology, potentially making future senescence research much easier. Senescent cells look different
Blood Pressure Linked to Dementia, Mortality in Older People
May 25, 2022
A recent study from the Journal of the American College of Cardiology, conducted by Dr. Wuxiang Xie and colleagues, examined the association of blood pressure with cognitive decline, dementia, and
Lithium Use Might Lower Risk of Dementia
May 25, 2022
A study published in Plos Medicine has shown that lithium decreases the risk of developing dementia and some of its subtypes, including Alzheimer’s disease and vascular dementia [1]. Enigmatic but
Urolithin A Improves Muscle Strength in Middle-Aged Adults
June 10, 2022
A new study published in Cell Reports Medicine shows that urolithin A supplementation improves muscle strength, fitness, and mitochondrial health in overweight, middle-aged adults [1]. Mitophagy in aging and in disease Mitochondrial dysfunction is one of the hallmarks of aging. It is associated with age-related skeletal
Drug Leads to Drastic Weight Loss With Diet and Exercise
June 9, 2022
A large Phase 3 study published in the New England Journal of Medicine shows that an existing drug combined with a healthy diet and mild exercise leads to an average weight loss of 20% [1]. Diet and exercise are not always enough Being a known comorbid
Spermidine Human Trial Results Fail to Impress
June 8, 2022
The results of a human clinical trial for spermidine against cognitive decline have recently been published, but the results are not positive. What is spermidine? Spermidine is a polyamine, meaning it has two or more primary amino groups. It is naturally occurring and is widely encountered
Antibody Therapy Alone Eliminates Certain Rectal Cancers
June 7, 2022
Researchers publishing in the New England Journal of Medicine have been able to completely eliminate stage 2 and 3 rectal tumors with a single monoclonal antibody drug [1]. Therapy comes with a price If we leave out skin cancers, colorectal cancer is the third most commonly
Senolytic Interventions Ameliorate Radiation Damage in Mice
June 6, 2022
In their publication in eLife Sciences, researchers at Newcastle University in the UK have illustrated how radiation-induced damage can be somewhat ameliorated with senolytics. These researchers focused on navitoclax along with the well-known combination of dasatinib and quercetin. A focus on cancer survivors The researchers begin
Modifiying Retrons for Better Gene Editing
June 3, 2022
A new study published in Nature Chemical Biology has described an advancement in the use of retrons, a novel method of genetic engineering that may become superior to CRISPR technology. A new solution for an old problem The researchers begin their paper by pointing out some
NMN Human Trial Results Published
June 2, 2022
The data from a multicenter NMN clinical trial have been published with some very modest but still interesting results [1]. What is NMN? NMN is short for nicotinamide mononucleotide, a naturally occurring molecule present in all species. It is a precursor of nicotinamide adenine dinucleotide (NAD+),
Fighting Alzheimer’s Disease with Increased Autophagy
June 1, 2022
In a new study published in Pharmacology Biochemistry and Behavior, researchers have shown that a combination of two compounds targeting different autophagy pathways is effective in fighting the pathological mechanism of Alzheimer’s disease in a mouse model [1]. Cleaning up is a big deal The accumulation
Rejuvenation Roundup May 2022
June 1, 2022
Two days ago, the United States honored its fallen veterans. How many of those heroes came home, having survived the horrors of war, only to have their own bodies betray them decades later? Here’s some of what’s been done to fight aging in May. LEAF News
Not All Hallmarks of Aging Contribute to Epigenetic Age
May 31, 2022
Scientists have shown that only some of the hallmarks of aging affect methylation clocks that are used to measure biological age [1]. The big black box Epigenetic clocks that measure biological age based on aging-related changes in genome methylation have been a great success. They enable
Chloroquine Increases Lifespan in Male Mice
May 30, 2022
Researchers publishing in Aging have found that the anti-malarial drug chloroquine increases lifespan in male NRMI mice. The NRMI, like the Black 6, is a standard breed widely used in research, and these mice were not directly genetically modified. Substantial positive lifespan effects We have previously
Plasmalogens Alleviate Age-Related Cognitive Decline in Mice
May 27, 2022
Scientists have learned that plasmalogens, obscure but important lipids, serve as a mediator of neurogenesis and synaptic health and can reverse age-related cognitive decline in mice [1]. Plasmalogens and membranes Plasmalogens are a subtype of phospholipids, the molecules that cellular membranes are mostly made of. Plasmalogens
Visually Identifying Senescent Cells with an Algorithm
May 26, 2022
A team of researchers publishing in Aging has developed a method of identifying senescent cells through their physical morphology, potentially making future senescence research much easier. Senescent cells look different Before modern biomarkers of senescence were eludicated, cell size was considered to be one of its
Blood Pressure Linked to Dementia, Mortality in Older People
May 25, 2022
A recent study from the Journal of the American College of Cardiology, conducted by Dr. Wuxiang Xie and colleagues, examined the association of blood pressure with cognitive decline, dementia, and mortality [1]. This study included two cohorts: the English Longitudinal Study of Ageing (ELSA) and the
Lithium Use Might Lower Risk of Dementia
May 25, 2022
A study published in Plos Medicine has shown that lithium decreases the risk of developing dementia and some of its subtypes, including Alzheimer’s disease and vascular dementia [1]. Enigmatic but effective According to WHO, Alzheimer’s disease and other dementias were the second-leading cause of death in