Lifespan Research Institute

Category: News

Common Aggregate

A Common Amyloid Between Brain Diseases

Research funded by the National Institutes of Health and published in Cell has thoroughly described a little-known amyloid aggregate that accumulates in the brains of people suffering from multiple proteostasis-related

Healthy Diet

Anti-Inflammatory Diet Lowers Risk of Dementia

In a population study, scientists have found that consuming foods associated with a low Diet Inflammatory Index substantially lowers the risk of dementia [1]. Aging is accompanied by an increase

Mouse TBI

Plant Compound Shown to Ameliorate Brain Injury

Publishing in Aging, a team of Taiwanese researchers has found that a chemical derived from Polygonum multiflorum, a herb native to southeastern China, aids in recovery from traumatic brain injury

Cat and mouse

Glutathione Extends Lifespan in Mice by 24%

In a study conducted by scientists from Baylor College of Medicine in Houston, supplementation of glutathione had a drastic effect on the lifespan of wild-type mice, both male and female

Champions of Coronavirus

Fighting COVID-19 by Counteracting Aging

A research paper that has just been peer reviewed and published in Nature has described how disrupting an immune pathway that is upregulated in aging decreases the lethality of COVID-19

Elderly professor

The Growing Increase in Cognitive Reserve

A study published in Brain Sciences has shown that mild cognitive impairment is less than half as common now as it was twenty years ago. Two cohorts, one study This

Clinical trial

Clinical Trials Targeting Aging

A miniature review of clinical trials targeting aging was published in Frontiers in Aging by Dr. Morten Scheibye-Knudsen and colleagues [1]. This review specifically focuses on interventions that have shown

Cell targeting

Using Gene Expression to Target Senescent Cells

An open access study published in iScience has discussed the development of senolytics to target particular genes that are upregulated in cellular senescence. Understanding senescence, cell by cell In our

Guinea pig

Tuberculosis Is Associated with Epigenetic Aging

Publishing in Aging, a team of researchers has explained the relationship between tuberculosis (TB) and multiple aspects of aging, including epigenetic alterations and the senescence-associated secretory phenotype (SASP). A disease

Common Aggregate

A Common Amyloid Between Brain Diseases

Research funded by the National Institutes of Health and published in Cell has thoroughly described a little-known amyloid aggregate that accumulates in the brains of people suffering from multiple proteostasis-related neurological disorders. Three classes of pathology, one protein fragment The authors of this study list three

Healthy Diet

Anti-Inflammatory Diet Lowers Risk of Dementia

In a population study, scientists have found that consuming foods associated with a low Diet Inflammatory Index substantially lowers the risk of dementia [1]. Aging is accompanied by an increase in chronic, low-grade inflammation, known as inflammaging, which has been linked to multiple age-related diseases. Inflammaging

Mouse TBI

Plant Compound Shown to Ameliorate Brain Injury

Publishing in Aging, a team of Taiwanese researchers has found that a chemical derived from Polygonum multiflorum, a herb native to southeastern China, aids in recovery from traumatic brain injury and encourages brain regeneration. The problem of glutamate Traumatic brain injury (TBI), the infliction of tissue

Spinal disc

Intervertebral Disc Rejuvenation Using Yamanaka Factors

Partial cellular reprogramming using Yamanka factors has become increasingly prominent in the world of aging research. A new study suggests that transient exposure to the Yamanaka factors might be the solution to intervertebral disc degeneration [1]. Partial cellular reprogramming with Yamanaka factors We have talked previously

Ramadan Fasting

Fasting During Ramadan and Acute Kidney Injury Incidence

A cohort study that was published in BioMed Central by Dr. Alsayyari and colleagues examined fasting on acute kidney injury incidence [1]. Background Fasting during the month of Ramandan is a obligation in Islam with exceptions, such as for chronic illness that has a poor prognosis

Cat and mouse

Glutathione Extends Lifespan in Mice by 24%

In a study conducted by scientists from Baylor College of Medicine in Houston, supplementation of glutathione had a drastic effect on the lifespan of wild-type mice, both male and female [1]. Dangerous species Oxidative stress happens when the delicate balance between the production and degradation of

Champions of Coronavirus

Fighting COVID-19 by Counteracting Aging

A research paper that has just been peer reviewed and published in Nature has described how disrupting an immune pathway that is upregulated in aging decreases the lethality of COVID-19 in a mouse model. Mice with COVID-19 As the researchers explain, normal mice do not use

Elderly and dog

Dog Ownership Lowers Risk of Disability in Old Age

In a new population study, scientists show that dog ownership is associated with a lower risk of developing disability in old age, though it does not affect all-cause mortality [1]. 1500+ dogs, and some cats too What can be more stereotypical than an old lady with

Elderly professor

The Growing Increase in Cognitive Reserve

A study published in Brain Sciences has shown that mild cognitive impairment is less than half as common now as it was twenty years ago. Two cohorts, one study This study used data from the Interdisciplinary Longitudinal Study of Adult Development and Aging (ILSE), which began

Microglia

Microglia Depletion Decreases Neuroinflammation in Mice

Scientists show that when done right, partial elimination of microglia, the immune cells of the brain, lowers age-related inflammation and cellular senescence [1]. Aging makes microglia bitter Brain health is of utmost importance for geroscientists, since the brain is the one organ that cannot be replaced,

Clinical trial

Clinical Trials Targeting Aging

A miniature review of clinical trials targeting aging was published in Frontiers in Aging by Dr. Morten Scheibye-Knudsen and colleagues [1]. This review specifically focuses on interventions that have shown strong clinical evidence that they impact aging. Caloric restriction We have previously discussed the effects of

Dina Radenkovic

Dina Radenkovic on the Root Cause of Gender Inequality

Our interviewee today holds that female reproductive aging, or ovarian aging, is accelerated compared to other organs and that it has a deep impact both on the lives and health of women and on our society as a whole. Nevertheless, ovarian aging continues to be underresearched,

Cell targeting

Using Gene Expression to Target Senescent Cells

An open access study published in iScience has discussed the development of senolytics to target particular genes that are upregulated in cellular senescence. Understanding senescence, cell by cell In our earlier interview with Simon Melov of the Buck Institute, the lead researcher of this paper, Dr.

Guinea pig

Tuberculosis Is Associated with Epigenetic Aging

Publishing in Aging, a team of researchers has explained the relationship between tuberculosis (TB) and multiple aspects of aging, including epigenetic alterations and the senescence-associated secretory phenotype (SASP). A disease known to cause long-term harm Tuberculosis, a disease that has proliferated around the world, kills 1.4

Mouse genes

Long-Term Cellular Reprogramming Causes Rejuvenation in Mice

Scientists have shown that in vivo partial cellular reprogramming can be safe and effective in an animal model, although the rejuvenation was mostly limited to long-term treatments and two tissue types [1]. There and back again Cellular reprogramming sounds like a technology from Star Trek, and