Category: News
Cell Cycle Stage Impacts the Efficacy of Senotherapeutics
October 1, 2025
A recent study reported that the effectiveness of the senotherapeutic drug ABT-263 depends on the cell’s DNA content, which is based on the cell cycle phase at which the senescent
Rejuvenation Roundup September 2025
October 1, 2025
Last month was full of news on both rejuvenation advocacy and rejuvenation advancements, including our new Public Longevity Group initiative along with our paper on Urolithin A being accepted into
Faulty Mitochondrial DNA Copying Might Cause Inflammaging
September 30, 2025
Scientists have discovered a possible mechanism behind age-related inflammation. It involves wrong building blocks being incorporated into mitochondrial DNA during replication and can be countered by adding the correct ones
A Combination Greatly Extends Lifespan in Male Mice
September 29, 2025
The Conboy lab in Berkeley has discovered a treatment combination that greatly extends lifespan in old male mice and published its findings in Aging. A combination with systemic effects The
New Universal Therapy Effective in Multiple Tumor Types
September 26, 2025
Scientists have reported a breakthrough in treating solid tumor cancers using a Velcro-like tool that targets glycans, surface sugars especially abundant in cancer cells. This potentially off-the-shelf therapy does not
A Potential Reason Why Clotting Increases With Age
September 25, 2025
In Aging Cell, researchers have described a method by which platelet-forming cells are rapidly generated from hematopoietic stem cells (HSCs), bypassing the intermediate cell types that are normally used to
Personalized Medicine Approach to Senolytics Clinical Trials
September 24, 2025
Recent commentary in Nature Aging summarized the results of clinical trials for senolytics and discussed recommendations for future clinical trials that use personalized medicine approaches [1]. From basic science to
Exercise Suppresses Appetite via a Brain Pathway
September 23, 2025
Scientists have discovered a pathway behind the known effect of exercise suppressing appetite: a lactate-related metabolite that acts directly on certain neurons. Not just more calories burned It has been
AI Model Accurately Predicts Multiple Disease Risks
September 22, 2025
European scientists have created a GPT-based model that can predict the risk of more than a thousand diseases on par with single-disease tools and biomarker-based models [1]. Tell me the
Lipid Metabolism Is Causal in Some Alzheimer’s Cases
September 19, 2025
In Aging Cell, researchers have outlined the relationship between Alzheimer’s, increased pain sensitivity, and the enzyme LPCAT2. Pain is among the earliest signs The key characteristics of Alzheimer’s disease, such
Looking Back at Summer, Looking Forward to Growth
September 18, 2025
For those of us in the Northern Hemisphere, autumn is underway. The fall is a time when the leaves that are green turn to brown, so let us see what
Partial Reprogramming Rejuvenates Aged Cells and Tissues
September 17, 2025
In a recent study, researchers investigated aging- and disease-associated changes in gene expression related to epithelial-mesenchymal transition. Inducing the Yamanaka factors in mice allowed them to rejuvenate cells and tissues
A Short-Term High-Fat Diet Harms Memory in Mice
September 16, 2025
Scientists have demonstrated that even two days on a Western-like high-fat diet reduce hippocampal glucose availability, which activates a subset of inhibitory neurons and causes memory problems in mice [1].
How Macrophages Manage Obesity and Change With Age
September 15, 2025
In Nature Aging, researchers have identified and categorized several macrophage subtypes, including a subtype that appears with aging and another that manages nerve function. Not all macrophages follow the same
Microplastics Cause Cognitive Deficits in APOE4 Mice
September 12, 2025
Scientists have demonstrated that short-term exposure to microplastics causes Alzheimer’s-like effects in mice expressing human APOE4 versus APOE3. These effects were sex-dependent, mirroring the disease in humans [1]. Microplastics and
Cell Cycle Stage Impacts the Efficacy of Senotherapeutics
October 1, 2025
A recent study reported that the effectiveness of the senotherapeutic drug ABT-263 depends on the cell’s DNA content, which is based on the cell cycle phase at which the senescent cell was arrested [1]. A personalized approach Last week, we discussed clinical trials of senolytics and
Rejuvenation Roundup September 2025
October 1, 2025
Last month was full of news on both rejuvenation advocacy and rejuvenation advancements, including our new Public Longevity Group initiative along with our paper on Urolithin A being accepted into Aging Cell. Here’s what’s happened in September. Team and activities Lifespan Research Institute Launches Public Longevity
Faulty Mitochondrial DNA Copying Might Cause Inflammaging
September 30, 2025
Scientists have discovered a possible mechanism behind age-related inflammation. It involves wrong building blocks being incorporated into mitochondrial DNA during replication and can be countered by adding the correct ones [1]. Too similar to bacteria Mitochondria, the cells’ energy-producing organelles, are considered to have developed from
A Combination Greatly Extends Lifespan in Male Mice
September 29, 2025
The Conboy lab in Berkeley has discovered a treatment combination that greatly extends lifespan in old male mice and published its findings in Aging. A combination with systemic effects The researchers begin this paper with a discussion of well-known interventions and their drawbacks. For example, they
New Universal Therapy Effective in Multiple Tumor Types
September 26, 2025
Scientists have reported a breakthrough in treating solid tumor cancers using a Velcro-like tool that targets glycans, surface sugars especially abundant in cancer cells. This potentially off-the-shelf therapy does not need adjustment to individual cancer types or patients. No sugarcoating this Antibody-based cancer immunotherapies, such as
A Potential Reason Why Clotting Increases With Age
September 25, 2025
In Aging Cell, researchers have described a method by which platelet-forming cells are rapidly generated from hematopoietic stem cells (HSCs), bypassing the intermediate cell types that are normally used to get there. Canonical and non-canonical formation It is well known that blood clots, which form when
Personalized Medicine Approach to Senolytics Clinical Trials
September 24, 2025
Recent commentary in Nature Aging summarized the results of clinical trials for senolytics and discussed recommendations for future clinical trials that use personalized medicine approaches [1]. From basic science to clinical trials Destroying senescent cells using senolytics may mitigate some aging-associated symptoms or diseases. Preclinical studies
Exercise Suppresses Appetite via a Brain Pathway
September 23, 2025
Scientists have discovered a pathway behind the known effect of exercise suppressing appetite: a lactate-related metabolite that acts directly on certain neurons. Not just more calories burned It has been long known that, somewhat counterintuitively, exercise transiently suppresses appetite. Scientists suspect that this contributes to exercise-related
AI Model Accurately Predicts Multiple Disease Risks
September 22, 2025
European scientists have created a GPT-based model that can predict the risk of more than a thousand diseases on par with single-disease tools and biomarker-based models [1]. Tell me the future! For millennia, people have wanted to know what health events await them in the future.
Lipid Metabolism Is Causal in Some Alzheimer’s Cases
September 19, 2025
In Aging Cell, researchers have outlined the relationship between Alzheimer’s, increased pain sensitivity, and the enzyme LPCAT2. Pain is among the earliest signs The key characteristics of Alzheimer’s disease, such as cognitive decline and brain deterioration, are very well-known [1]. However, other symptoms, such as pain
Looking Back at Summer, Looking Forward to Growth
September 18, 2025
For those of us in the Northern Hemisphere, autumn is underway. The fall is a time when the leaves that are green turn to brown, so let us see what the Lifespan team has been working on to help our field keep our own metaphorical leaves
Partial Reprogramming Rejuvenates Aged Cells and Tissues
September 17, 2025
In a recent study, researchers investigated aging- and disease-associated changes in gene expression related to epithelial-mesenchymal transition. Inducing the Yamanaka factors in mice allowed them to rejuvenate cells and tissues and reverse some of these aging-associated changes [1]. Rejuvenating cellular identity Aging-related epigenetic changes result in
A Short-Term High-Fat Diet Harms Memory in Mice
September 16, 2025
Scientists have demonstrated that even two days on a Western-like high-fat diet reduce hippocampal glucose availability, which activates a subset of inhibitory neurons and causes memory problems in mice [1]. Is it OK to eat junk occasionally? Metabolic disease and obesity are known to harm cognitive
How Macrophages Manage Obesity and Change With Age
September 15, 2025
In Nature Aging, researchers have identified and categorized several macrophage subtypes, including a subtype that appears with aging and another that manages nerve function. Not all macrophages follow the same rules Macrophages declining with age is a well-known problem, and many proposed solutions involve changing their
Microplastics Cause Cognitive Deficits in APOE4 Mice
September 12, 2025
Scientists have demonstrated that short-term exposure to microplastics causes Alzheimer’s-like effects in mice expressing human APOE4 versus APOE3. These effects were sex-dependent, mirroring the disease in humans [1]. Microplastics and the brain Exposure to tiny particles that plastic products shed (microplastics) has been linked to increased