Category: News
What is Rapamycin? A Summary of Rapamycin
October 8, 2021
We take a look at rapamycin and why some researchers think it could be useful in combating aging. What is rapamycin? Rapamycin is a macrolide, a class of antibiotic that
How a Protein Is Linked to Kidney Fibrosis With Age
October 7, 2021
Publishing in Aging, a team of researchers has reported that periostin, a protein that aids in development during the embryonic stage, is linked to kidney problems related to lipid metabolism
Matching an Epigenetic Clock to Physical Function
October 6, 2021
A new, three-year study published in The Journals of Gerontology: Series A examined the relationship between epigenetic clocks and physical performance in older women. Epigenetic clocks and biological age Epigenetic
Exercise Burns Fewer Calories Than Previously Thought
October 5, 2021
Researchers have proven that our bodies partially compensate for calories burned during exercise by cutting energy expenditure on vital functions. Their discovery might explain why it can be so hard
Engineering Anti-Inflammatory Cells to Fight Arthritis
October 4, 2021
Publishing in Science Advances, a team of researchers has described how a scaffold containing genetically engineered induced pluripotent stem cells (iPSCs) can reduce symptoms in a mouse model of rheumatoid
Some Mutations Increase Cancer Risk by Making Cells Older
October 1, 2021
Cells from the breasts of women with mutations that increase their risk of breast cancer show signs of accelerated aging, according to new research [1]. Accelerated aging may make these
Rejuvenation Roundup September 2021
October 1, 2021
One second, one life: this axiom was true when LEAF was founded, and it remains true today. More than one person a second dies from age-related diseases, not including contagious
Study Suggests No Theoretical Limit on Human Lifespan
September 30, 2021
According to new research, it may be possible for humans to live 130 years or perhaps longer, but the chances of reaching that age are slim. New findings suggest that
The Effects of Caloric Restriction on Stem Cells
September 29, 2021
A review published in The Malaysian Journal of Medical Sciences has outlined what effects caloric restriction (CR) has on the development and differentiation of stem cells. Stem cells and their
Activity and Diet Shown to Slow Aging (Again)
September 28, 2021
Scientists have used DNA methylation markers to measure the anti-aging effects of healthy diet and physical activity, reaching interesting, if at times contradictory, results [1]. Move, eat healthy, check your
What is Nicotinamide Riboside? A Summary of NR
September 27, 2021
Nicotinamide riboside (NR) is part of the B3 vitamin family. Like other forms of vitamin B3, nicotinamide riboside gets converted into nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for life.
Our Brains’ Metabolism Changes as We Age
September 24, 2021
A study conducted in Sweden and published in Scientific Reports has outlined the relationship between aging and the metabolites present in cerebrospinal fluid (CSF), which cushions and supports the brain
Getting Proteins Right to Live Longer
September 23, 2021
Changing a single amino acid in a single protein boosts the fidelity of protein synthesis, and that is enough to increase lifespan in a variety of organisms, according to new
Dr. Morgan Levine on Building a Better Epigenetic Clock
September 22, 2021
In her lab at Yale, Dr. Morgan Levine tackles some of the most exciting and difficult problems in geroscience. She specializes in bioinformatics and is working on creating and finessing
Senolytics Alleviate Spinal Disc Degeneration in Mice
September 21, 2021
A group of researchers has found that early long-term treatment of mice with the popular senolytic duo dasatinib and quercetin alleviates symptoms of intervertebral disc degeneration, a major age-related cause
What is Rapamycin? A Summary of Rapamycin
October 8, 2021
We take a look at rapamycin and why some researchers think it could be useful in combating aging. What is rapamycin? Rapamycin is a macrolide, a class of antibiotic that includes erythromycin, roxithromycin, azithromycin, and clarithromycin. Rapamycin exhibits potent antitumor and immunosuppressive activity. Where is rapamycin
How a Protein Is Linked to Kidney Fibrosis With Age
October 7, 2021
Publishing in Aging, a team of researchers has reported that periostin, a protein that aids in development during the embryonic stage, is linked to kidney problems related to lipid metabolism in adults. Why does this protein exist? The researchers cite prior studies showing that periostin is
Matching an Epigenetic Clock to Physical Function
October 6, 2021
A new, three-year study published in The Journals of Gerontology: Series A examined the relationship between epigenetic clocks and physical performance in older women. Epigenetic clocks and biological age Epigenetic clocks attempt to estimate age based on measurable DNA modifications. However, not every individual ages at
Exercise Burns Fewer Calories Than Previously Thought
October 5, 2021
Researchers have proven that our bodies partially compensate for calories burned during exercise by cutting energy expenditure on vital functions. Their discovery might explain why it can be so hard to lose weight by working out [1]. The three components of energy expenditure As much as
Engineering Anti-Inflammatory Cells to Fight Arthritis
October 4, 2021
Publishing in Science Advances, a team of researchers has described how a scaffold containing genetically engineered induced pluripotent stem cells (iPSCs) can reduce symptoms in a mouse model of rheumatoid arthritis. The advantage over current drugs Rheumatoid arthritis (RA) is currently treated through drugs that often
Some Mutations Increase Cancer Risk by Making Cells Older
October 1, 2021
Cells from the breasts of women with mutations that increase their risk of breast cancer show signs of accelerated aging, according to new research [1]. Accelerated aging may make these cells worse at suppressing cancer development, offering both an explanation for the effect of these mutations
Rejuvenation Roundup September 2021
October 1, 2021
One second, one life: this axiom was true when LEAF was founded, and it remains true today. More than one person a second dies from age-related diseases, not including contagious diseases that youthful immune health would likely have protected them from. Let’s see what progress has
Study Suggests No Theoretical Limit on Human Lifespan
September 30, 2021
According to new research, it may be possible for humans to live 130 years or perhaps longer, but the chances of reaching that age are slim. New findings suggest that mortality risk plateaus past 110 For many years now, just how long a human being can
The Effects of Caloric Restriction on Stem Cells
September 29, 2021
A review published in The Malaysian Journal of Medical Sciences has outlined what effects caloric restriction (CR) has on the development and differentiation of stem cells. Stem cells and their exhaustion The reviewers began by discussing stem cell exhaustion, a hallmark of aging and a common
Activity and Diet Shown to Slow Aging (Again)
September 28, 2021
Scientists have used DNA methylation markers to measure the anti-aging effects of healthy diet and physical activity, reaching interesting, if at times contradictory, results [1]. Move, eat healthy, check your biological age Physical activity (PA) and healthy diet are two powerful interventions that have time and
What is Nicotinamide Riboside? A Summary of NR
September 27, 2021
Nicotinamide riboside (NR) is part of the B3 vitamin family. Like other forms of vitamin B3, nicotinamide riboside gets converted into nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for life. For this reason, it is often called a NAD+ precursor because it is part of the
Our Brains’ Metabolism Changes as We Age
September 24, 2021
A study conducted in Sweden and published in Scientific Reports has outlined the relationship between aging and the metabolites present in cerebrospinal fluid (CSF), which cushions and supports the brain and spine. A detailed, metabolic analysis The researchers extracted CSF from 41 people aged 20 to
Getting Proteins Right to Live Longer
September 23, 2021
Changing a single amino acid in a single protein boosts the fidelity of protein synthesis, and that is enough to increase lifespan in a variety of organisms, according to new research [1]. Proofreading proteins The loss of proteostasis is one of the hallmarks of aging. However,
Dr. Morgan Levine on Building a Better Epigenetic Clock
September 22, 2021
In her lab at Yale, Dr. Morgan Levine tackles some of the most exciting and difficult problems in geroscience. She specializes in bioinformatics and is working on creating and finessing clocks that measure biological age. We talked with Dr. Levine about her work, the impact that
Senolytics Alleviate Spinal Disc Degeneration in Mice
September 21, 2021
A group of researchers has found that early long-term treatment of mice with the popular senolytic duo dasatinib and quercetin alleviates symptoms of intervertebral disc degeneration, a major age-related cause of disability [1]. Age-related disease with early onset Conventional wisdom says that our spines just were