Category: Press Releases
Organ Fat Is Associated With Carotid Atherosclerosis
October 29, 2025
A recent study discovered an association between visceral and, to a lesser extent, hepatic fat with cardiovascular risk factors and carotid atherosclerosis. This association persists even after adjusting for cardiovascular
Review Links Lingering Infections to Senescence
October 28, 2025
In a comprehensive review, scientists discuss the various mechanisms by which chronic infections drive cellular senescence and aging [1]. Lurking in the body People are mostly aware of acute infections,
Stiff Collagen May Lead to Senescent Cells
October 27, 2025
A preprint study has found that the stiffness of the extracellular matrix (ECM) itself encourages cells to undergo senescence. An unexplored relationship ECM stiffness and cellular senescence are both well-known
Amyloid-Fibrinogen Complexes Exacerbate Alzheimer’s in Mice
October 24, 2025
A study from Rockefeller University suggests that an unholy duo of two proteins causes harm in much lower concentrations than either of them alone. This points to a possible route
Measuring Dog Aging With Protein Metabolism
October 23, 2025
Researchers working with data from the Dog Aging Project have found that post-translationally modified amino acids (ptmAAs), which are generated from protein metabolism, are useful in determining the biological ages
Andrea Maier on Longevity Medicine for All
October 22, 2025
Dr. Andrea Maier, Oon Chiew Seng Professor in Medicine at the National University of Singapore, is a veteran geroscientist and one of the most familiar faces in the rising field
Addressing Age-Related Vision Decline With Lipid Supplements
October 22, 2025
Researchers have partially reversed age-related vision decline in mice by injecting lipids directly into the retina [1]. The lipids in the retina The membranes that surround our cells are made
Tiny Brain Organoids Show Promise in Alzheimer’s Research
October 21, 2025
Scientists have developed a novel multicellular integrated brain model to study neurological diseases, incorporating all six major brain cell types derived from patient-specific induced pluripotent stem cells (iPSCs) [1]. Beyond
How Being in Orbit Affects Stem Cells
October 20, 2025
In Cell Stem Cell, researchers from the Cedars-Sinai Medical Center have published a review discussing what experiments conducted in space can do for stem cell research and medical research as
Female-Specific Mechanism of Neurodegeneration Discovered
October 17, 2025
Scientists have found that a gene on the X chromosome, which escapes silencing, promotes inflammation and neurodegeneration in a mouse model of multiple sclerosis, but the effects can be reversed
Infrared Lasers Clear Harmful Compounds in Mouse Brains
October 16, 2025
Researchers have discovered that infrared lasers promote the clearance of toxic metabolites from the brains of age-accelerated mice by improving lymphatic drainage. Gunking up the works Advanced glycation end-products (AGEs),
Interventions Testing Program Finds Three New Compounds
October 15, 2025
A new report from the Interventions Testing Program adds three new compounds to the list of lifespan-extending compounds confirmed during their experiments: epicatechin, halofuginone, and mitoglitazone [1]. Rigorous testing The National
Why Naked Mole Rats Have Better DNA Repair
October 14, 2025
Scientists have found that the cGAS protein in naked mole rats, a famously long-lived species, boosts DNA repair, while the human version tends to hamper it. The difference boils down
Researchers Identify Key Age-Related Genes
October 13, 2025
In Aging Cell, researchers have described core genes that apply to a wide variety of species and appear to be causal drivers of aging. Looking for signals in the noise
Nanoparticles Potently Reverse Alzheimer’s in Mice
October 10, 2025
Scientists have created polymersomes, a type of nanoparticle, that latch onto a master regulator of amyloid-beta clearance, diverting it towards a more efficient route. The treatment drained Aβ from mouse
Organ Fat Is Associated With Carotid Atherosclerosis
October 29, 2025
A recent study discovered an association between visceral and, to a lesser extent, hepatic fat with cardiovascular risk factors and carotid atherosclerosis. This association persists even after adjusting for cardiovascular risk factors [1]. Beyond BMI Body mass index (BMI) is a metric that compares height to total weight, including fat
Review Links Lingering Infections to Senescence
October 28, 2025
In a comprehensive review, scientists discuss the various mechanisms by which chronic infections drive cellular senescence and aging [1]. Lurking in the body People are mostly aware of acute infections, such as the common cold, COVID-19, and malaria. Science has made great strides against these kinds of infectious diseases, making
Stiff Collagen May Lead to Senescent Cells
October 27, 2025
A preprint study has found that the stiffness of the extracellular matrix (ECM) itself encourages cells to undergo senescence. An unexplored relationship ECM stiffness and cellular senescence are both well-known aspects of aging. The cross-linked collagens, such as glucosepane, that lead to a less-flexible ECM accumulate with time and have
Amyloid-Fibrinogen Complexes Exacerbate Alzheimer’s in Mice
October 24, 2025
A study from Rockefeller University suggests that an unholy duo of two proteins causes harm in much lower concentrations than either of them alone. This points to a possible route for intervention [1]. When amyloid met fibrinogen Amyloid beta (Aβ) and tau proteins are the usual suspects in Alzheimer’s disease.
Measuring Dog Aging With Protein Metabolism
October 23, 2025
Researchers working with data from the Dog Aging Project have found that post-translationally modified amino acids (ptmAAs), which are generated from protein metabolism, are useful in determining the biological ages of dogs. The Dog Aging Project With enrollment beginning in 2020, the Dog Aging Project (DAP) is an initiative to
Andrea Maier on Longevity Medicine for All
October 22, 2025
Dr. Andrea Maier, Oon Chiew Seng Professor in Medicine at the National University of Singapore, is a veteran geroscientist and one of the most familiar faces in the rising field of longevity medicine, which aims to translate the early successes of geroscience into clinical practice. Parallel to her scientific career,
Addressing Age-Related Vision Decline With Lipid Supplements
October 22, 2025
Researchers have partially reversed age-related vision decline in mice by injecting lipids directly into the retina [1]. The lipids in the retina The membranes that surround our cells are made of lipids and proteins. The composition of lipids, which changes as we age, impacts many biophysical properties of these membranes.
Tiny Brain Organoids Show Promise in Alzheimer’s Research
October 21, 2025
Scientists have developed a novel multicellular integrated brain model to study neurological diseases, incorporating all six major brain cell types derived from patient-specific induced pluripotent stem cells (iPSCs) [1]. Beyond organoids Organoids, tiny lab-grown patches of tissue, are a promising tool for accelerating medical research [2]. They sit a step
How Being in Orbit Affects Stem Cells
October 20, 2025
In Cell Stem Cell, researchers from the Cedars-Sinai Medical Center have published a review discussing what experiments conducted in space can do for stem cell research and medical research as a whole. Cells behave differently in microgravity The gravitational effects of freefalling in orbit are very difficult to properly simulate
Female-Specific Mechanism of Neurodegeneration Discovered
October 17, 2025
Scientists have found that a gene on the X chromosome, which escapes silencing, promotes inflammation and neurodegeneration in a mouse model of multiple sclerosis, but the effects can be reversed with metformin. Human RNA sequencing data supports these findings [1]. Why are women more vulnerable? Multiple sclerosis (MS) is an
Infrared Lasers Clear Harmful Compounds in Mouse Brains
October 16, 2025
Researchers have discovered that infrared lasers promote the clearance of toxic metabolites from the brains of age-accelerated mice by improving lymphatic drainage. Gunking up the works Advanced glycation end-products (AGEs), like their acronym suggests, accumulate with age. These substances, which are formed when sugars bind to other molecules without the
Interventions Testing Program Finds Three New Compounds
October 15, 2025
A new report from the Interventions Testing Program adds three new compounds to the list of lifespan-extending compounds confirmed during their experiments: epicatechin, halofuginone, and mitoglitazone [1]. Rigorous testing The National Institute on Aging’s Interventions Testing Program (ITP) is designed to rigorously test potential lifespan-extending compounds with a protocol that ensures
Why Naked Mole Rats Have Better DNA Repair
October 14, 2025
Scientists have found that the cGAS protein in naked mole rats, a famously long-lived species, boosts DNA repair, while the human version tends to hamper it. The difference boils down to just four amino acids [1]. DNA repair and cGAS Despite their unassuming appearance, naked mole rats (NMRs) are stars
Researchers Identify Key Age-Related Genes
October 13, 2025
In Aging Cell, researchers have described core genes that apply to a wide variety of species and appear to be causal drivers of aging. Looking for signals in the noise Introducing their study, the researchers note that gene expression changes are difficult to interpret because they occur across a panoply
Nanoparticles Potently Reverse Alzheimer’s in Mice
October 10, 2025
Scientists have created polymersomes, a type of nanoparticle, that latch onto a master regulator of amyloid-beta clearance, diverting it towards a more efficient route. The treatment drained Aβ from mouse brains within hours and, after a short dosing regimen, restored cognition to near wild-type levels [1]. Get it out of