Tag: Brain

In Aging Cell, researchers have explained how the sirtuin SIRT6 protects against proteostasis-related brain disorders by maintaining the function of nucleoli and limiting protein production. The nucleus and nucleoli Loss of ProteostasisThe loss of proteostasis is the failure of the protein-building machinery of the cell and the accumulation of misfolded proteins, which is one of...

Resesarchers have found that thrombospondin-1 (TSP-1), a compound that is critical in growing brain synapses, is secreted by normal astrocytes but not senescent ones. Senescence is harmful to the brain Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...

In a paper published in Aging Cell, researchers have described how older cells send long interspersed nuclear element-1 (LINE-1) RNA to other cells in extracellular vesicles (EVs), spurring inflammation. Evil EVs In the literature, EVs are often discussed in a therapeutic context, as they can be used to send beneficial signals. However, EVs are the...

A recent study investigated biomarkers that can help monitor trajectories of Alzheimer’s disease-related molecular processes, such as neuronal cell death, and how patients respond to treatments. The authors reported that using biomarkers enabled them to gain insights into the molecular processes that contribute to improved cognition following human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF, sargramostim)...

A new review highlights the promise of microglia replacement, a strategy that made the leap from mouse studies to the first successful human trial in just five years [1]. Repair or replace Microglia, the resident immune cells of the brain, have been implicated in various diseases, including Alzheimer’s [2]. However, treatments modulating microglial behavior are...

Researchers have recently published a review on how cannabis use among older adults impacts age-related conditions and longevity [1]. Cannabinoids and longevity In recent years, researchers have observed an increase in cannabis use among older adults, mostly for chronic conditions, such as arthritis, pain, sleep improvement, anxiety, and depressive symptoms. However, there is also a...