Tag: Dasatinib

Recent commentary in Nature Aging summarized the results of clinical trials for senolytics and discussed recommendations for future clinical trials that use personalized medicine approaches [1]. From basic science to clinical trials Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they...

The results of a Phase 1 trial of the well-known senolytic combination of dasatinib and quercetin (D+Q) in patients with Alzheimer's disease have been published in Neurotherapeutics. Building on substantial previous work What Are Senolytics? Senotherapeutics for Senescent CellsSenolytics work by targeting one of several pro-survival pathways that senescent cells use to evade apoptosis and...

A paper published in Aging Cell offers evidence for the idea that senolytics might be a treatment for acute liver sepsis. A deadly condition linked to a hallmark of aging Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...

Scientific Reports has published a study that used a computational approach to identify natural senotherapeutics that have a similar impact on gene expression as a known senotherapeutic drug, dasatinib [1]. Drug combinations for better treatments Cellular senescence, a state in which cells cannot divide anymore but are still metabolically active and often display senescence-associated secretory...

The authors of a paper published in Pharmaceuticals tested multiple drug-polyphenol combinations to find the ones with the best senolytic properties [1]. Targeting senescent cells in lung diseases Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they...

In a research paper published in GeroScience, researchers investigated the impact of senolytics on young mice and found some surprising results [1]. Senescent cell removal and other properties Senolytics, when given to older mice, clear senescent cells. Senolytics such as fisetin and quercetin also have anti-inflammatory properties and can be used as chemotherapeutics and senotherapeutics...