July 17, 2025
In Molecular Therapy, researchers have described their creation of cells that express the regenerative factor GDF11 and found that they ameliorate fibrosis in a mouse model. Context-dependent benefits Like sirtuins and klotho, GDF11 is a biochemical factor that has been heavily investigated in the context of age-related diseases [1]. However, research on it has been...
August 17, 2023
Researchers publishing in Biogerontology have tested multiple biomarkers in an effort to use them as proxies for aging, and some of their findings were surprising. A simple study with direct measurements Unlike other association studies that are used to evaluate biomarkers of aging, this study did not use data from a pre-existing biobank or related...
March 10, 2023
Scientists have shown that the protein GDF11 can reverse depression-like symptoms in naturally aged mice and in a mouse model of depression. Depressed humans have lower GDF11 as well [1]. Depression and aging Severe mental disorders, including depression, have been linked to significantly shorter lifespans [2]. According to one study, depressed people “have a higher...
November 25, 2020
Elevian is a company that we have been keeping an eye on for a while, as it works on identifying blood factors that can spur regeneration. In particular, the company has been working with a naturally occurring molecule known as growth differentiation factor 11 (GDF11). Previous research has shown that when aged mice are given...