Tag: Hallmarks of Aging

Researchers have published a review of the current state of combination therapies that address multiple Hallmarks of Aging [1]. Some of these combined therapies were found to induce greater lifespan extension than single treatments. A complex phenomenon calls for complex treatments The complexity of aging cannot be underestimated. It is unlike individual diseases, which primarily...

Dr. Michael Lustgarten delivers a clear and enlightening exploration of the intricate relationship between microbial burden and aging in Microbial Burden: A Major Cause of Aging and Age-Related Disease and What We Can Do to Fight Back! Through meticulous research and compelling analysis, the author sheds light on the profound impact of microbial burden and...

A review paper published in Cells has described multiple ways in which the secretion of extracellular vesicles (EVs) changes with aging, leading the authors to propose it as its own hallmark. Extracellular vesicles and their uses This review begins with an outline and explanation of extracellular vesicles and their classifications. Cells use extracellular vesicles to...

The year 2023 started with the publication of two remarkable review papers in Cell and Cell Metabolism by researchers addressing the hallmarks of aging and their interplay with the hallmarks of cancer [1,2]. These papers were authored by the same team that published the original 2013 Hallmarks of Aging paper [3]. The Reasons We Age...

In a new review article published in Frontiers in Cell and Developmental Biology, researchers have suggested adding cellular enlargement to the hallmarks of aging [1]. Bigger is not always better Different cell types are known to have different shapes and sizes, which are dictated by their functions. In humans, sperm cells (male gametes) and ova...

Researchers publishing in Nature Communications have determined that interventions that extend lifespan in mice may not have significant effects on the processes of aging. Improvement is not the same as slowing decline The researchers begin this paper by noting that previous studies have outlined a broad variety of dietary, environmental, and genetic factors that are...