Tag: Interventions Testing Program

In the newest study by the Interventions Testing Program, 16α-hydroxyestriol and canagliflozin significantly increased lifespan in male mice but were deleterious for females [1]. The golden standard The Interventions Testing Program, now entering its 20th year, is a monumental undertaking by the National Institute on Aging aimed at rigorously testing compounds for their possible effects...

The authors of a recent paper published in GeroScience used an alternative statistical test to reanalyze data from the Interventions Testing Program and identified additional life‑extending compounds [1]. The crucial step of data analysis A typical biological experiment can be divided into three stages: planning, executing, and results analysis. The last part can be done...

Scientists in the Intervention Testing Program have found that the antioxidant astaxanthin and the seasickness medication meclizine, both sold over the counter, significantly extend median lifespan in mice [1]. Astaxanthin and meclizine are in, but fisetin is out The Intervention Testing Program (ITP) has existed for about 20 years, and it is considered the gold...

A team of researchers, including Matt Kaeberlein and Brian Kennedy, has published a preprint discussing the necessity of using long-lived animals in life extension research. The Interventions Testing Program (ITP) uncovers weaknesses The ITP is run by the National Institutes of Aging and described by these researchers as being rigorous and a gold standard. Its...

In a new study published in Nature Aging, researchers have shown that aging is associated with a decreased expression of long transcripts over multiple tissues across several animal species [1]. Global changes It is well known that aging is accompanied by changes in the expression of many genes. Therefore, numerous studies have focused on identifying...

In a new study published in Aging Cell, researchers have tested several individual drugs and a combination of rapamycin plus acarbose as potential life extension agents in genetically heterogeneous mice [1]. Anti-aging agent testing Identification of successful anti-aging interventions is arguably one of the most challenging research problems to date. In addition to the complexity...