Tag: Metformin

In a new study, metformin, which has already shown good results in rodents and in human epidemiological studies, alleviated multiple signs of aging in male cynomolgus monkeys [1]. Now in monkeys Metformin, a well-established anti-diabetes drug, has been touted as a possible geroprotector since a study suggested that diabetes patients on metformin outlived age-matched healthy...

Scientists have used a huge database to find links between existing drugs and human lifespan. Only 14 of more than 400 showed a positive correlation [1]. Reinventing the wheel? One of the subfields in geroscience was born from the idea that some drugs currently in use for various indications might slow aging. In recent years,...

A review recently published in BMC Biology suggests that taking gerotherapeutics while exercising doesn’t have advantages over separate treatments [1]. Are two approaches better than one? Exercise is a well-established intervention that ameliorates several aspects of aging. Similarly, other research suggests that certain drugs, known as gerotherapeutics, target biological processes in a way that benefits...

A paper published in GeroScience has described a gene responsible for a key biomarker of cellular senescence. A widely used biomarker Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful chemical...

Researchers publishing in Aging Cell have documented a human clinical trial showing that metformin reduces atrophy caused by long periods of bed rest. A common problem and a well-known diabetes drug Long periods of disuse cause muscles to atrophy and accelerate the age-related muscle wasting known as sarcopenia [1]. Strength training is the accepted treatment...

In a new study published in Aging Cell, researchers have shown that two promising anti-aging agents, the antibiotic rapamycin and the anti-diabetic drug metformin, reverse aging in a population of intestinal stem cells [1]. The aging intestine Older people are more prone to gastrointestinal problems [2]. Moreover, aging is a major risk factor for various...