Tag: Mitochondrial Dysfunction

Scientists from the Longevity Research Institute (LRI), which was formed by the merger of SENS Research Foundation and Lifespan.io, have achieved expression of an essential mitochondrial gene in the nucleus and proper functioning of the protein. This could pave the way for curing diseases caused by mitochondrial mutations [1]. The fragile mitochondrial DNA The prevailing...

In a study published in Aging Cell, researchers have outlined a relationship between mitochondrial fragmentation in skeletal muscle and the loss of strength with age. Broken power plants Why We Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and release reactive oxygen species that harm cells...

Scientists have found that human heart tissue is harmed by even a short stint in orbit. This might have implications for future space travel [1]. Fly me to the Moon Space exploration is cool, but the human body was obviously not made for it. All its systems have evolved to function under normal gravity and...

In Aging Cell, researchers have described the chemical ways in which excessive visceral fat causes oxidative stress and cellular senescence. Visceral fat is metabolically active Metabolic syndrome, a host of intertwined disorders that include obesity and cholesterol imbalance, is known to have multiple harmful effects that lead to decreased lifespan. These include a propensity towards...

In Aging Cell, researchers have published details on the pathway by which a compound commonly found in ketone bodies ameliorates osteoarthritis in a rat model. Chondrocytes are crucial in arthritis The cartilage holding joints together is built and maintained by chondrocytes, which synthesize such necessary proteins as collagen and aggrecan [1]. Unfortunately, the cellular senescence...

In Aging Cell, researchers have published a paper on a cellular energy source that appears to be a key signaling molecule in sarcopenia. A little-explored molecule Sarcopenia, a condition that increases with aging, reduces muscle mass in older people, and leads to a decreased quality of life [1], has been documented to have multiple root...