Tag: mtDNA

Scientists have investigated a little-known mechanism that fuels cellular senescence: mitochondrial RNA leaking into the cytoplasm. Targeting this mechanism showed promise in a mouse model of fatty liver [1]. The new target The increasing abundance of senescent cells with age has been linked to numerous diseases and is considered a hallmark of aging. Understanding why...

Creating induced pluripotent stem cells (iPSCs) causes mutant mitochondrial populations to change, and researchers have investigated this phenomenon more thoroughly. Easy to mutate Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and release reactive oxygen species that harm cells and cause increasing levels of systemic inflammation.Read More...

Scientists have found that leakage of mitochondrial DNA in senescent cells is a major cause of their pro-inflammatory activity, and it can be targeted without clearing those cells out [1]. A new aspect of senescence Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues...

Researchers publishing in Nature Biotechnology have developed a novel method of editing mitochondrial DNA, which cannot be accomplished with nuclear DNA tools. Where CRISPR doesn't work Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and release reactive oxygen species that harm cells and cause increasing levels of...

A new study conducted by a team of Japanese scientists and published in Scientific Reports details how cells can have their damaged mitochondria destroyed and replaced with healthy ones, offering a potential solution to the problem of mitochondrial dysfunction. Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy...

Researchers have developed what can be described as the first precision gene editing tool for mitochondrial DNA (mtDNA). This new tool is different from the well-known CRISPR/Cas9 method of gene editing and should make the study of mitochondrial biology and mitochondrial diseases easier. This new discovery is a game changer Prior to this, creating mouse...