July 12, 2024
By making NK cells insensitive to tumor-secreted TGF-β, scientists have improved their efficacy against this deadly hepatocellular carcinoma (HCC) [1]. Liver cancer and TGF-β Cancer cells, which are supposed to be vulnerable to the immune system, develop various defensive mechanisms to avoid detection and decrease immune cells’ fitness and viability. In solid tumors, the dense...
May 11, 2023
Researchers publishing in Nature Biotechnology have demonstrated a method of protecting mass-produced stem cells from the immune system, with strongly positive results in two different animal models. Fake ID for the immune system While it would be ideal to create stem cells from each person's existing cells to replace that particular person's needs and losses,...
July 25, 2022
Scientists have shown that the effectiveness of natural killer cells, a crucial component of the immune system, is directly linked to NAD+ levels [1]. Naturally deadly Natural killer cells (NK) are an important part of the innate immune system. They got this designation, in arguably the best act of naming in the history of cellular...
March 07, 2022
Publishing in Aging, a team of researchers from SENS Research Foundation has described a new method of enriching natural killer (NK) cells to fight senescent cells. Culturing NK cells to fight senescence Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues...
October 03, 2018
Led by Dr. Alicja Copik, scientists at the University of Central Florida College of Medicine have discovered that it might be possible to make cancer immunotherapy work for a larger portion of patients by employing PM21-activated natural killer (PM21-NK) cells [1]. Study abstract Anti-PD-1/anti-PD-L1 therapies have shown success in cancer treatment but responses are limited...