Tag: Natural Killer Cells

In Aging Cell, researchers have described why older natural killer (NK) cells lose their ability to eliminate harmful cells and a potential treatment for this decline. Judgment and ability At the cellular level, there is no due process. Natural killer (NK) cells judge other cells' guilt or innocence by their surface proteins. They ruthlessly exterminate...

A new preprint study from Calico has found that the local brain environment is the primary driver of microglial aging. After being transplanted into old brains, young cells adopted aged characteristics, but their susceptibility to these signals could be turned off [1]. Microglia grow old and irritable Brain aging holds a special place in the...

By making NK cells insensitive to tumor-secreted TGF-β, scientists have improved their efficacy against this deadly hepatocellular carcinoma (HCC) [1]. Liver cancer and TGF-β Cancer cells, which are supposed to be vulnerable to the immune system, develop various defensive mechanisms to avoid detection and decrease immune cells’ fitness and viability. In solid tumors, the dense...

Researchers publishing in Nature Biotechnology have demonstrated a method of protecting mass-produced stem cells from the immune system, with strongly positive results in two different animal models. Fake ID for the immune system While it would be ideal to create stem cells from each person's existing cells to replace that particular person's needs and losses,...

Scientists have shown that the effectiveness of natural killer cells, a crucial component of the immune system, is directly linked to NAD+ levels [1]. Naturally deadly Natural killer cells (NK) are an important part of the innate immune system. They got this designation, in arguably the best act of naming in the history of cellular...

Publishing in Aging, a team of researchers from SENS Research Foundation has described a new method of enriching natural killer (NK) cells to fight senescent cells. Culturing NK cells to fight senescence Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they...