Tag: Partial Cellular Reprogramming

Scientists have shown that in a direct cellular reprogramming scenario, neurons are produced almost exclusively by a rare subtype of multipotent cells. Their findings, they claim, change our understanding of reprogramming, but not everyone agrees [1]. Direct action In the world of cellular reprogramming, the two most well-known realms are pluripotent reprogramming, in which somatic...

Life Biosciences is a company co-founded by the celebrity geroscientist David Sinclair and is based on his Harvard team’s research into partial cellular reprogramming. In the heated race to translate this promising technology to the clinic, Life has emerged as one of the favorites, inching closer towards clinical trials in humans. Life is counting on...

Scientists have shown that long-term intermittent reprogramming limited to hippocampal neurons increases their fitness and improves cognitive function in a mouse model of Alzheimer’s disease [1]. Targeted in time and space Partial cellular reprogramming is one of the hottest directions in longevity research for a reason: it allows to rejuvenate cells without driving them all...

Dr. Belmonte’s group at Altos Labs targeted stressed and senescent cells with partial reprogramming, producing large increases in lifespan in male mice [1]. What are they doing there? Since the discovery of cellular reprogramming almost two decades ago, a lot of hopes have been put into this technology, and a lot of progress has been...

Scientists have shown that prolonged, continuous expression of reprogramming factors counters cognitive decline in old rats and probably decreases their epigenetic age [1]. Reprogramming and cognitive function Cellular reprogramming, the act of bringing differentiated cells back to a stem-like pluripotent state by expressing certain genes, has been one of the hottest subfields in longevity in...

Scientists have found that partial cellular reprogramming, both full-body and restricted to specific brain regions, rescues neurogenesis in the brains of old mice [1]. Cells going back in time Yamanaka Factors - Opportunities for RejuvenationDrs. Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4, and c-Myc (OSKM) to reprogram cells back to pluripotent, embryonic...