Tag: Sarcopenia

Scientists have found a positive correlation between the abundance of the bacterium Roseburia inulinivorans in the gut and muscle strength in mice and humans, although the mechanism behind it is still unclear [1]. Can bacteria mimic exercise? As we age, we lose muscle mass and strength. This decline is a major driver of frailty, disability,...

In Aging Cell, researchers have discovered a potential way to use a microRNA to diagnose sarcopenia, the age-related loss of muscle. Primary and secondary sarcopenia Previous research has been able to distinguish sarcopenia by its sources. Primary sarcopenia directly comes from the processes of aging, while secondary sarcopenia is a side effect of such things...

Researchers have discovered that exosomes secreted by mesenchymal stem cells derived from human umbilical cord tissue (hucMSC-Exos) restore muscle function in a mouse model of sarcopenia. Useful messengers Exosomes are vesicles that carry molecular messages from cell to cell. When derived from youthful sources, they have been repeatedly found to have benefits in multiple animal...

A recent study investigated the effect of a single treatment of prostaglandin E2 on improving muscle strength and rejuvenating muscle stem cells in mice. The researchers explored the molecular and epigenetic aspects underlying this rejuvenation [1]. Aging muscle stem cells Sarcopenia, a loss of skeletal muscle mass and strength, is an age-related disorder that leads...

In Aging Cell, Dr. Vadim Gladyshev and a team of researchers have described how elamipretide beneficially affects mitochondrial pathways and reverses frailty in mice. A drug on its way to the clinic As a mitochondria-affecting antioxidant peptide, elamipretide has been, and continues to be, the subject of multiple investigations. As far back as 2004, researchers...

The authors of a recent study describe Ginkgolide B, a compound with senotherapeutic potential that improved muscle health, metabolism, frailty, inflammation, and senescence metrics and increased lifespan in female mice [1]. From East Asia to the clinic Ginkgolide B is a compound that can be extracted from Ginkgo biloba, an East Asian tree known as...