Category: News
Breanna Deutsch Explains How to Find the Fountain
October 27, 2020
Aging research is still an emerging field, and its emergence has been laden with difficulties. Until recently, the budgets were scarce, the ideas ridiculed, and public involvement nonexistent. The tide
Partial Cellular Reprogramming Improves Memory in Old Mice
October 26, 2020
Today, we want to highlight another study that takes us a step closer to getting partial cellular reprogramming to the clinic. Can we both have our cake and eat it?
A Genetic Footprint of Aging
October 22, 2020
A new analysis has revealed a core set of genes involved in aging in both humans and mice. Together with a broader set of age-related genes assembled by the study
Generating Neural Progenitor Cells from iPSCs
October 21, 2020
The latest research published in the Journal of Tissue Engineering and Regenerative Medicine has reprogrammed pig fibroblast cells into neural progenitor cells.
A New Mechanism of Telomere Lengthening in T Cells Discovered
October 20, 2020
An international collective of scientists has discovered a new cellular process: telomere transfer from antigen-presenting cells to T cells that boosts the latter’s lifespan and proliferative potential [1]. T cells,
Using CRISPR to Remove Mutated DNA to Defeat Cancer
October 19, 2020
Researchers have successfully used the CRISPR/Cas9 gene editing tool to destroy Ewing’s sarcoma and chronic myeloid leukemia tumor cells by targeting the fusion genes responsible for these tumors [1]. Fusion
Insilico Partners with Taisho for Senolytic Drug Discovery
October 16, 2020
Insilico Medicine has announced a historic deal with the Taisho Pharmaceutical Company, which is based in Japan, in a partnership to identify and develop new senolytic drugs. The companies have
Uncovering the Origin of the SASP
October 15, 2020
A new study published in Nature shows a strong link between the protein G3BP1 and the SASP, a harmful byproduct of senescent cells.
Fatty Tissue Generated on a Chip
October 14, 2020
Recent research published in the scientific journal Lab on a Chip sheds light on the behavior of adipocytes, the primary cells of our fat tissue.
T Cell Progenitors Boost Stem Cell Therapy Effectiveness
October 13, 2020
In a review paper, a group of scientists highlight a new strategy that addresses the shortcomings of stem cell therapy by adding T cell progenitors to the graft [1]. HSCT
A New Senolytic Enters Human Trials
October 13, 2020
Unity Biotechnology has recently announced the launch of its Phase 1 study of UBX1325 for patients with diabetic macular edema. The drug is designed to remove problematic senescent cells from
Regenerating Skin With a Single Protein
October 12, 2020
Researchers have identified a factor present in the skin of baby mice that controls the formation of hair follicles during their early development. The factor is turned off in adult
Creating Anti-Glucosepane Antibodies
October 9, 2020
New research takes us a step close to finding ways to remove the advanced glycation end-product known as glucosepane, a likely reason why our arteries stiffen as we age. A
Senescent Cells Have Less SIRT1 as a Result of Autophagy
October 8, 2020
Genes in the sirtuin family are conserved across a wide range of species and are involved in cellular metabolism, immune response, and aging. SIRT1 is known to decline during aging,
A New Atlas of Dental Cells
October 7, 2020
A recent study published in Nature Communications has outlined an atlas for the various differentiated and stem cell populations found in our teeth.
Breanna Deutsch Explains How to Find the Fountain
October 27, 2020
Aging research is still an emerging field, and its emergence has been laden with difficulties. Until recently, the budgets were scarce, the ideas ridiculed, and public involvement nonexistent. The tide is turning, with more private and institutional players eager to spend money and effort on the
Partial Cellular Reprogramming Improves Memory in Old Mice
October 26, 2020
Today, we want to highlight another study that takes us a step closer to getting partial cellular reprogramming to the clinic. Can we both have our cake and eat it? As previous studies [1] have taught us, partial cellular reprogramming is a balancing act of epigenetically
A Genetic Footprint of Aging
October 22, 2020
A new analysis has revealed a core set of genes involved in aging in both humans and mice. Together with a broader set of age-related genes assembled by the study [1], this resource will serve as a launching point for further investigations of the mechanisms behind
Generating Neural Progenitor Cells from iPSCs
October 21, 2020
The latest research published in the Journal of Tissue Engineering and Regenerative Medicine has reprogrammed pig fibroblast cells into neural progenitor cells.
A New Mechanism of Telomere Lengthening in T Cells Discovered
October 20, 2020
An international collective of scientists has discovered a new cellular process: telomere transfer from antigen-presenting cells to T cells that boosts the latter’s lifespan and proliferative potential [1]. T cells, an important element of our adaptive immune system, are born as non-proliferating cells and, as such,
Using CRISPR to Remove Mutated DNA to Defeat Cancer
October 19, 2020
Researchers have successfully used the CRISPR/Cas9 gene editing tool to destroy Ewing’s sarcoma and chronic myeloid leukemia tumor cells by targeting the fusion genes responsible for these tumors [1]. Fusion genes, a feature in many different types of cancer, arise when a mutation fuses two genes
Insilico Partners with Taisho for Senolytic Drug Discovery
October 16, 2020
Insilico Medicine has announced a historic deal with the Taisho Pharmaceutical Company, which is based in Japan, in a partnership to identify and develop new senolytic drugs. The companies have agreed to collaborate on AI-powered drug discovery focused on identifying molecules to remove problematic senescent cells.
Uncovering the Origin of the SASP
October 15, 2020
A new study published in Nature shows a strong link between the protein G3BP1 and the SASP, a harmful byproduct of senescent cells.
Fatty Tissue Generated on a Chip
October 14, 2020
Recent research published in the scientific journal Lab on a Chip sheds light on the behavior of adipocytes, the primary cells of our fat tissue.
T Cell Progenitors Boost Stem Cell Therapy Effectiveness
October 13, 2020
In a review paper, a group of scientists highlight a new strategy that addresses the shortcomings of stem cell therapy by adding T cell progenitors to the graft [1]. HSCT has a problem Today, one of the few ways to alleviate immune system damage from chemotherapy
A New Senolytic Enters Human Trials
October 13, 2020
Unity Biotechnology has recently announced the launch of its Phase 1 study of UBX1325 for patients with diabetic macular edema. The drug is designed to remove problematic senescent cells from the body which accumulate as we get older and are a reason we age. UBX1325 is
Regenerating Skin With a Single Protein
October 12, 2020
Researchers have identified a factor present in the skin of baby mice that controls the formation of hair follicles during their early development. The factor is turned off in adult mice, but when it is turned back on, it allows them to regenerate their skin following
Creating Anti-Glucosepane Antibodies
October 9, 2020
New research takes us a step close to finding ways to remove the advanced glycation end-product known as glucosepane, a likely reason why our arteries stiffen as we age. A possible solution to the problem Some years ago, Aubrey de Grey from the SENS Research Foundation
Senescent Cells Have Less SIRT1 as a Result of Autophagy
October 8, 2020
Genes in the sirtuin family are conserved across a wide range of species and are involved in cellular metabolism, immune response, and aging. SIRT1 is known to decline during aging, but the mechanisms involved in this process were not known. Now, an international team has clarified
A New Atlas of Dental Cells
October 7, 2020
A recent study published in Nature Communications has outlined an atlas for the various differentiated and stem cell populations found in our teeth.