Category: Biology of Aging
A Potential Gene Therapy for Hearing Loss
January 6, 2025
In JCI Insight, researchers have explored the possibility of using gene therapy to restore a crucial protein and repair hearing loss. Hearing and its failure In mammals, afferent neurons, which
Keeping Stem Cells Healthy and Young
January 2, 2025
A team of researchers has outlined a new approach that uses mRNA to prevent senescence and strengthen mesenchymal stem cells (MSCs) against aging before they are transplanted into patients. Stem
How Cellular Reprogramming Affects Mitochondrial Dysfunction
December 19, 2024
Creating induced pluripotent stem cells (iPSCs) causes mutant mitochondrial populations to change, and researchers have investigated this phenomenon more thoroughly. Easy to mutate Being outside of the protection of the
A Senolytic Approach to Faster Wound Healing
December 17, 2024
Researchers have published in Aging their findings that a senolytic compound accelerates wound healing in aged mice when it is administered before the wound occurs. A well-known laboratory senolytic While
Encouraging Hair Growth by Reducing Senescence
December 16, 2024
In Aging Cell, researchers have described how to improve the hair growth potential of stem cells and organoids by reducing cellular senescence. The quest for a true stem cell hair
Extending Monkeys’ Reproductive Span With Stem Cells
December 11, 2024
An investigation into transplanting human embryonic stem cells (hESC)-derived MSC-like cells (M cells) into the ovaries of cynomolgus monkeys suggests an extension of female reproductive span accompanied by a reduction
Senescent Cells Protect the Bladder
December 10, 2024
In Aging Cell, a research team has explained why barrier cells in the human bladder are largely senescent and what might lead them to become cancerous. Targeting the right cells
Nuclear Expression of a Mitochondrial Gene in Mice
December 6, 2024
Scientists from the Longevity Research Institute (LRI), which was formed by the merger of SENS Research Foundation and lifespan.io, have achieved expression of an essential mitochondrial gene in the nucleus
Fragmented Mitochondria Linked to Muscle Weakness
December 5, 2024
In a study published in Aging Cell, researchers have outlined a relationship between mitochondrial fragmentation in skeletal muscle and the loss of strength with age. Broken power plants As its
Resveratrol, Vitamin C Drop Oxidative Stress After Menopause
December 4, 2024
In a randomized, controlled trial published in Nutrients, researchers tested supplementation with resveratrol, vitamin C, and a combination of both. They learned that all of the treatments had a similar
Building an Atlas of Human Ovarian Aging
November 27, 2024
The researchers of a Nature Aging paper used multi-omics approaches to investigate cellular, molecular, and genetic drivers of human ovarian aging [1]. An early decline A decline in ovarian function
Finding Cells That Send Signals Against Arthritis
November 25, 2024
In Aging, researchers have reported that deriving extracellular vesicles from mesenchymal stromal cells (MSCs) in fat tissue has beneficial effects in models of osteoarthritis. Which source to use? Earlier this
Intranasal Spray Alleviates Early Alzheimer’s in Mice
November 19, 2024
A novel therapy based on induced neuronal stem cells shows promise in a mouse model of Alzheimer’s disease – and it can be administered intranasally [1]. Who needs cells? Stem
Engineering T Cells to Fight Brain Cancer
November 18, 2024
Researchers publishing in Nature have reported a new advance in developing chimeric antigen receptor (CAR) T cells to fight solid tumors in the brain. A difficult endeavor CAR T cell-based
Study of Direct Reprogramming Challenges Consensus
November 15, 2024
Scientists have shown that in a direct cellular reprogramming scenario, neurons are produced almost exclusively by a rare subtype of multipotent cells. Their findings, they claim, change our understanding of
A Potential Gene Therapy for Hearing Loss
January 6, 2025
In JCI Insight, researchers have explored the possibility of using gene therapy to restore a crucial protein and repair hearing loss. Hearing and its failure In mammals, afferent neurons, which originate from the inner ear, transform received stimuli (sound waves) into electrical signals [1]. This process
Keeping Stem Cells Healthy and Young
January 2, 2025
A team of researchers has outlined a new approach that uses mRNA to prevent senescence and strengthen mesenchymal stem cells (MSCs) against aging before they are transplanted into patients. Stem cells go bad before they can be used The researchers introduce this study by focusing on
How Cellular Reprogramming Affects Mitochondrial Dysfunction
December 19, 2024
Creating induced pluripotent stem cells (iPSCs) causes mutant mitochondrial populations to change, and researchers have investigated this phenomenon more thoroughly. Easy to mutate Being outside of the protection of the nucleus, mitochondria DNA (mtDNA) mutates at anywhere from 10 to 100 times the rate of nuclear
A Senolytic Approach to Faster Wound Healing
December 17, 2024
Researchers have published in Aging their findings that a senolytic compound accelerates wound healing in aged mice when it is administered before the wound occurs. A well-known laboratory senolytic While some senescent cells have been found to have a beneficial effect on wound healing [1], the
Encouraging Hair Growth by Reducing Senescence
December 16, 2024
In Aging Cell, researchers have described how to improve the hair growth potential of stem cells and organoids by reducing cellular senescence. The quest for a true stem cell hair treatment There has been a substantial amount of previous work in restoring hair follicle growth by
Extending Monkeys’ Reproductive Span With Stem Cells
December 11, 2024
An investigation into transplanting human embryonic stem cells (hESC)-derived MSC-like cells (M cells) into the ovaries of cynomolgus monkeys suggests an extension of female reproductive span accompanied by a reduction in senescence-associated processes, such as inflammation, fibrosis, oxidative damage, and apoptosis [1]. Increasing healthspan by delaying
Senescent Cells Protect the Bladder
December 10, 2024
In Aging Cell, a research team has explained why barrier cells in the human bladder are largely senescent and what might lead them to become cancerous. Targeting the right cells It is well-known that people develop urinary problems with advanced age, including increasing frequency and incontinence
Nuclear Expression of a Mitochondrial Gene in Mice
December 6, 2024
Scientists from the Longevity Research Institute (LRI), which was formed by the merger of SENS Research Foundation and lifespan.io, have achieved expression of an essential mitochondrial gene in the nucleus and proper functioning of the protein. This could pave the way for curing diseases caused by
Fragmented Mitochondria Linked to Muscle Weakness
December 5, 2024
In a study published in Aging Cell, researchers have outlined a relationship between mitochondrial fragmentation in skeletal muscle and the loss of strength with age. Broken power plants As its authors point out, this is far from the first study to link mitochondrial dysfunction and aging
Resveratrol, Vitamin C Drop Oxidative Stress After Menopause
December 4, 2024
In a randomized, controlled trial published in Nutrients, researchers tested supplementation with resveratrol, vitamin C, and a combination of both. They learned that all of the treatments had a similar positive impact on oxidative stress in postmenopausal women [1]. Menopausal transition Around the world, a significant
Building an Atlas of Human Ovarian Aging
November 27, 2024
The researchers of a Nature Aging paper used multi-omics approaches to investigate cellular, molecular, and genetic drivers of human ovarian aging [1]. An early decline A decline in ovarian function occurs before a similar decline in other organs. Already in their mid-to-late thirties, women can experience
Finding Cells That Send Signals Against Arthritis
November 25, 2024
In Aging, researchers have reported that deriving extracellular vesicles from mesenchymal stromal cells (MSCs) in fat tissue has beneficial effects in models of osteoarthritis. Which source to use? Earlier this month, we wrote about how small extracellular vesicles derived from embryonic cells (ESC-sEVs) alleviate arthritis in
Intranasal Spray Alleviates Early Alzheimer’s in Mice
November 19, 2024
A novel therapy based on induced neuronal stem cells shows promise in a mouse model of Alzheimer’s disease – and it can be administered intranasally [1]. Who needs cells? Stem cell therapies have made great strides in recent decades. They have been successfully employed against numerous
Engineering T Cells to Fight Brain Cancer
November 18, 2024
Researchers publishing in Nature have reported a new advance in developing chimeric antigen receptor (CAR) T cells to fight solid tumors in the brain. A difficult endeavor CAR T cell-based therapies are normally discussed in the context of blood cancers, as getting them to effectively attack
Study of Direct Reprogramming Challenges Consensus
November 15, 2024
Scientists have shown that in a direct cellular reprogramming scenario, neurons are produced almost exclusively by a rare subtype of multipotent cells. Their findings, they claim, change our understanding of reprogramming, but not everyone agrees [1]. Direct action In the world of cellular reprogramming, the two