Category: Biology of Aging
Partial Reprogramming Extends Lifespan in Old Mice
January 25, 2023
The journal club returns on Tuesday 31st January at 12:00 Eastern on our Facebook page with host Dr. Oliver Medvedik. We are looking at a preprint this time where partial
Allogeneic CAR-T Cells Complete Phase 1 Trial
January 23, 2023
The results of a Phase 1 clinical trial of allogeneic CAR T cell therapy against multiple myeloma have been published today in Nature Medicine, and they appear to be promising.
Senescent Cells Leave Fragments Attached to Other Cells
January 20, 2023
In a preprint paper, scientists have reported that senescent cells transiently adhere to neighboring cells, and, upon departure, leave in place large membrane-enclosed fragments of themselves [1]. Mysterious fragments Cellular
Exploring the Biological Aging Advice in “Younger You”
January 20, 2023
Dr. Kara Fitzgerald’s new book provides an evidence-based approach to diet and lifestyle that aims to reduce your biological age. Beginning with epigenetics Younger You offers a pragmatic and easily
Introducing A Longevity Hackathon for Accelerating Research
January 20, 2023
The latest hackathon event, LongHack, hosted by the VitaDAO team beginning today and continuing over the weekend, will focus on discovering new approaches to longevity science and inspiring new initiatives
The APOE4 Gene Is Associated With Worse Stroke Outcomes
January 19, 2023
Researchers publishing in Aging have found that there is a correlation between the APOE4 gene and poor outcomes after ischemic stroke. An allele with a long and sordid history Other
Questioning the Usefulness of Model Organisms
January 18, 2023
In a new review paper published in GeroScience, the researchers explored the translatability of anti-aging interventions across species and received somewhat alarming results [1]. Necessary, but not the best Model
The Microbiome Might Affect Motivation for Exercise
January 17, 2023
Scientists publishing in Nature have found that compounds produced by some types of gut bacteria can influence dopamine levels in the brain and, as a result, might influence motivation to
NMN Alleviates Silicate Lung Injury in Mice
January 16, 2023
A new paper published in Nutrients shows that the well-known NAD+ precursor NMN alleviates lung injury caused by silicate inhalation in wild-type mice. An antioxidant approach to a common problem
David Sinclair: Epigenetic Info Loss Is a Cause of Aging
January 13, 2023
Published in Cell, a new paper by David Sinclair and his team argues that epigenetic dysregulation in the form of information loss is a major driver of aging, but it
Obesity Shown to Affect Brain Aging in Mice
January 12, 2023
Research published in Immunity & Ageing has shown that obesity has significant, aging-associated effects on behavior and immunity in the brains of mice. Known effects on humans and mice The
Senescent Cells Harm Muscle Regeneration in Mice
January 4, 2023
New research published in Nature has shown that senescent cells hamper muscle regeneration through inflammation and fibrosis [1]. Cellular senescence is one of the hallmarks of aging. However, there is
Novel Longevity Gene Variants Identified in Centenarians
January 4, 2023
In a study published in International Journal of Molecular Sciences, a team of researchers known for their studies on long-lived individuals has discovered four new genetic loci that partially explain
Changes To The Lamina Contribute To Heart Weakness
December 22, 2022
A paper just published in Nature Aging has explained how changes to the lamina contribute to heart weakness in model organisms. A protective enclosure for genetic stability Lamin proteins enclose
Transcriptome-Wide Organization Changes in Aging
December 21, 2022
In a new study published in Nature Aging, researchers have shown that aging is associated with a decreased expression of long transcripts over multiple tissues across several animal species [1].
Partial Reprogramming Extends Lifespan in Old Mice
January 25, 2023
The journal club returns on Tuesday 31st January at 12:00 Eastern on our Facebook page with host Dr. Oliver Medvedik. We are looking at a preprint this time where partial reprogramming factors were used to reverse some aspects of aging in old mice. The paper is
Allogeneic CAR-T Cells Complete Phase 1 Trial
January 23, 2023
The results of a Phase 1 clinical trial of allogeneic CAR T cell therapy against multiple myeloma have been published today in Nature Medicine, and they appear to be promising. B cells, engineered T cells, and lymphodepletion Multiple myeloma is a cancer of the plasma B
Senescent Cells Leave Fragments Attached to Other Cells
January 20, 2023
In a preprint paper, scientists have reported that senescent cells transiently adhere to neighboring cells, and, upon departure, leave in place large membrane-enclosed fragments of themselves [1]. Mysterious fragments Cellular senescence is central to aging, but there are still a lot of unknowns around this complex
Exploring the Biological Aging Advice in “Younger You”
January 20, 2023
Dr. Kara Fitzgerald’s new book provides an evidence-based approach to diet and lifestyle that aims to reduce your biological age. Beginning with epigenetics Younger You offers a pragmatic and easily understood primer on the role of epigenetics and aging along with an exquisitely detailed plan for
Introducing A Longevity Hackathon for Accelerating Research
January 20, 2023
The latest hackathon event, LongHack, hosted by the VitaDAO team beginning today and continuing over the weekend, will focus on discovering new approaches to longevity science and inspiring new initiatives in the field. What is LongHack? LongHack is a longevity-focused hackathon that is hosted by VitaDAO
The APOE4 Gene Is Associated With Worse Stroke Outcomes
January 19, 2023
Researchers publishing in Aging have found that there is a correlation between the APOE4 gene and poor outcomes after ischemic stroke. An allele with a long and sordid history Other than its well-known association with Alzheimer’s disease, the APOE4 allele, which codes for the ApoE4 apolipoprotein
Questioning the Usefulness of Model Organisms
January 18, 2023
In a new review paper published in GeroScience, the researchers explored the translatability of anti-aging interventions across species and received somewhat alarming results [1]. Necessary, but not the best Model organisms have been widely and successfully used to understand the molecular processes driving disease pathologies, identify
The Microbiome Might Affect Motivation for Exercise
January 17, 2023
Scientists publishing in Nature have found that compounds produced by some types of gut bacteria can influence dopamine levels in the brain and, as a result, might influence motivation to go on a morning run [1]. We’ve got company We tend to think of ourselves as
NMN Alleviates Silicate Lung Injury in Mice
January 16, 2023
A new paper published in Nutrients shows that the well-known NAD+ precursor NMN alleviates lung injury caused by silicate inhalation in wild-type mice. An antioxidant approach to a common problem Silicosis is an occupational hazard encountered by people who are regularly exposed to silica dust [1].
David Sinclair: Epigenetic Info Loss Is a Cause of Aging
January 13, 2023
Published in Cell, a new paper by David Sinclair and his team argues that epigenetic dysregulation in the form of information loss is a major driver of aging, but it can be reversed in vivo by partial cellular reprogramming. Genome or epigenome? Both genomic instability and
Obesity Shown to Affect Brain Aging in Mice
January 12, 2023
Research published in Immunity & Ageing has shown that obesity has significant, aging-associated effects on behavior and immunity in the brains of mice. Known effects on humans and mice The researchers introduce this study by discussing human studies. It is well known that obesity is a
Senescent Cells Harm Muscle Regeneration in Mice
January 4, 2023
New research published in Nature has shown that senescent cells hamper muscle regeneration through inflammation and fibrosis [1]. Cellular senescence is one of the hallmarks of aging. However, there is a growing understanding that, just like aging itself, senescence is a complex and heterogeneous phenomenon [2].
Novel Longevity Gene Variants Identified in Centenarians
January 4, 2023
In a study published in International Journal of Molecular Sciences, a team of researchers known for their studies on long-lived individuals has discovered four new genetic loci that partially explain extreme longevity [1]. Genetics can be friend or foe Centenarians are people who have lived for
Changes To The Lamina Contribute To Heart Weakness
December 22, 2022
A paper just published in Nature Aging has explained how changes to the lamina contribute to heart weakness in model organisms. A protective enclosure for genetic stability Lamin proteins enclose the nucleus in the lamina, the cellular envelope that contains and protects DNA. In progeria, a
Transcriptome-Wide Organization Changes in Aging
December 21, 2022
In a new study published in Nature Aging, researchers have shown that aging is associated with a decreased expression of long transcripts over multiple tissues across several animal species [1]. Global changes It is well known that aging is accompanied by changes in the expression of