Category: Biology of Aging
Senescent Cell Death Promotes Aging Resistance
July 30, 2020
The well-known resistance of naked mole rats to aging and aging-related effects is due at least in part to an unusual ability to clear away senescent cells. This suggests that
The “Love Hormone” Oxytocin as an Alzheimer’s Therapy
July 29, 2020
Japanese researchers led by Professor Akiyoshi Saitoh from the Tokyo University of Science have published new research that explores the potential of oxytocin as a therapy to combat cognitive disorders
Scientists Induce a New Mode of Aging in Yeast
July 28, 2020
A group of researchers has shown that yeast cells have two different and mutually exclusive modes of aging that seem to be interlinked. The scientists were also able to artificially
A Single Molecule Can Regenerate the Gut Lining
July 27, 2020
New research from Monash University has shown that a single key molecule responsible for cell adhesion and a variety of other bodily functions is also critical in repairing the gut
A DNA Methylation Clock to Measure Skin Age
July 24, 2020
A team of researchers have developed a tissue-specific clock that can measure the biological age of skin. There is plenty of new evidence that different organs and tissues in our
Why NAD+ Declines During Aging – Part 1
July 23, 2020
There has been considerable debate around the age-related decline of NAD+, particularly regarding whether or not it occurs in humans as it does in other species, such as mice. Today,
Hyperbaric Oxygen Therapy May Reduce Cognitive Decline
July 21, 2020
A group of Israeli scientists led by Prof. Shai Efrati investigated the effects of hyperbaric oxygen therapy (HBOT) on age-related cognitive decline in healthy older adults, and the results were
Genomic Instability May Directly Lead to Diseases of Aging
July 16, 2020
A new perspective published in Cell explains a direct link between genomic instability and age-related diseases [1]. Somatic mutations Mutation is normally explained as the driving force behind evolution, as
The First Precision Gene Editing Tool for Mitochondrial DNA
July 14, 2020
Researchers have developed what can be described as the first precision gene editing tool for mitochondrial DNA (mtDNA). This new tool is different from the well-known CRISPR/Cas9 method of gene
A Blood Factor Boosts Neurogenesis and Cognition
July 13, 2020
By now, the race to discover regenerative factors present in blood has been underway for a number of years, with numerous researchers seeking a “secret sauce” in blood that has
Trimethylamine May be Involved in Vascular Aging
July 10, 2020
Researchers suggest that trimethylamine, a metabolic byproduct that is created when bacteria in the gut break down foods such as red meat, may be a key player in vascular aging.
Selectivity of the Blood-Brain Barrier Changes with Age
July 9, 2020
The mechanisms at work in the blood-brain barrier change with age, affecting the selectivity of this vital interface. The blood-brain barrier The blood-brain barrier is a layer of cells in
Frailty and Age-Related Immune Decline Reversed in Mice
July 8, 2020
Frailty and the decline of the immune system are two typical features of aging, but new research shows that both can be halted and even somewhat reversed using a novel
Repetitions in Our DNA React to Anti-Aging Interventions
July 7, 2020
A group of scientists from Colorado State University has discovered that repetitive elements (REs) in our DNA increase with aging and react to known longevity-promoting interventions [1]. Are REs genomic
Parkinson’s Disease Symptoms Reversed in Mice
July 3, 2020
Researchers have found that blocking the activity of a single gene causes other cell types to become dopamine-producing neurons, a type of neuron that Parkinson’s disease destroys. What is Parkinson’s
Senescent Cell Death Promotes Aging Resistance
July 30, 2020
The well-known resistance of naked mole rats to aging and aging-related effects is due at least in part to an unusual ability to clear away senescent cells. This suggests that senolytic drugs, which aim to do the same in humans, may prove a fruitful path to
The “Love Hormone” Oxytocin as an Alzheimer’s Therapy
July 29, 2020
Japanese researchers led by Professor Akiyoshi Saitoh from the Tokyo University of Science have published new research that explores the potential of oxytocin as a therapy to combat cognitive disorders such as Alzheimer’s disease. Oxytocin is often called the love hormone, given its role in the
Scientists Induce a New Mode of Aging in Yeast
July 28, 2020
A group of researchers has shown that yeast cells have two different and mutually exclusive modes of aging that seem to be interlinked. The scientists were also able to artificially induce a third mode of aging that prolongs both healthspan and lifespan. Yeast is a popular
A Single Molecule Can Regenerate the Gut Lining
July 27, 2020
New research from Monash University has shown that a single key molecule responsible for cell adhesion and a variety of other bodily functions is also critical in repairing the gut lining and that increasing the presence of this molecule accelerates its repair and regeneration. Supercharging stem
A DNA Methylation Clock to Measure Skin Age
July 24, 2020
A team of researchers have developed a tissue-specific clock that can measure the biological age of skin. There is plenty of new evidence that different organs and tissues in our body age at different rates. In particular, the epigenetic state, the pattern of gene expression, of
Why NAD+ Declines During Aging – Part 1
July 23, 2020
There has been considerable debate around the age-related decline of NAD+, particularly regarding whether or not it occurs in humans as it does in other species, such as mice. Today, as part of a two-part special, we are going to be taking a look at some
Hyperbaric Oxygen Therapy May Reduce Cognitive Decline
July 21, 2020
A group of Israeli scientists led by Prof. Shai Efrati investigated the effects of hyperbaric oxygen therapy (HBOT) on age-related cognitive decline in healthy older adults, and the results were promising. The brain is the most metabolically active organ in the body, but it has only
Genomic Instability May Directly Lead to Diseases of Aging
July 16, 2020
A new perspective published in Cell explains a direct link between genomic instability and age-related diseases [1]. Somatic mutations Mutation is normally explained as the driving force behind evolution, as changes in the germ lines of organisms result in beneficial and harmful mutations to organisms. The
The First Precision Gene Editing Tool for Mitochondrial DNA
July 14, 2020
Researchers have developed what can be described as the first precision gene editing tool for mitochondrial DNA (mtDNA). This new tool is different from the well-known CRISPR/Cas9 method of gene editing and should make the study of mitochondrial biology and mitochondrial diseases easier. This new discovery
A Blood Factor Boosts Neurogenesis and Cognition
July 13, 2020
By now, the race to discover regenerative factors present in blood has been underway for a number of years, with numerous researchers seeking a “secret sauce” in blood that has the potential to rejuvenate aged tissues and organs. A fork in the road It is clear
Trimethylamine May be Involved in Vascular Aging
July 10, 2020
Researchers suggest that trimethylamine, a metabolic byproduct that is created when bacteria in the gut break down foods such as red meat, may be a key player in vascular aging. Trimethylamine and vascular aging Some researchers believe that trimethylamine damages our arteries, according to a new
Selectivity of the Blood-Brain Barrier Changes with Age
July 9, 2020
The mechanisms at work in the blood-brain barrier change with age, affecting the selectivity of this vital interface. The blood-brain barrier The blood-brain barrier is a layer of cells in the blood vessels of the brain that prevents molecules in the blood from crossing into the
Frailty and Age-Related Immune Decline Reversed in Mice
July 8, 2020
Frailty and the decline of the immune system are two typical features of aging, but new research shows that both can be halted and even somewhat reversed using a novel cell-based therapy. Frailty and immunosenescence Frailty is something that frequently affects older people, and it ultimately
Repetitions in Our DNA React to Anti-Aging Interventions
July 7, 2020
A group of scientists from Colorado State University has discovered that repetitive elements (REs) in our DNA increase with aging and react to known longevity-promoting interventions [1]. Are REs genomic parasites? At the dawn of genomic research scientists were stunned to learn that as much as
Parkinson’s Disease Symptoms Reversed in Mice
July 3, 2020
Researchers have found that blocking the activity of a single gene causes other cell types to become dopamine-producing neurons, a type of neuron that Parkinson’s disease destroys. What is Parkinson’s disease? Parkinson’s disease is a progressive, age-related, neurodegenerative disease that mainly affects the motor system and