Category: Biology of Aging
Alzheimer’s Reversed by Editing a Single Gene
May 24, 2018
Researchers at Gladstone Institutes in San Francisco report that a gene variant associated with Alzheimer’s works differently in mice and humans, and they also demonstrate how modifying this gene
NAD+ Regulates the Creation of Fat Cells
May 22, 2018
Researchers from the University of Texas have discovered how NAD+ creation and consumption in cells is linked to glucose metabolism and their transformation from preadipocytes into adipocytes, or as most people
Recoding Human Cells to Make them Virus Proof
May 8, 2018
On May 1, around 200 scientists from the Genome Project-write (GP-write) met in Boston and announced the first target of their project: the creation of cells that cannot be infected
Fasting might boost intestinal stem cell function
May 7, 2018
Stem cells supply the specialized cells that make up our tissues and organs; every time existing cells are lost for whatever reason, stem cells that can differentiate into that particular
Using Peptides to Regrow Human Teeth
April 16, 2018
Researchers at the University of Washington have developed a therapy that uses peptides to promote the regrowth of tooth enamel in order to treat dental cavities. An end to tooth
Promising Results for Age-Related Macular Degeneration Trial
April 9, 2018
Researchers at the USC Roski Eye Institute, in collaboration with other institutions in California, have shown that a new stem cell-based retinal implant could help people with dry age-related macular
Activating Natural Killer T cells to Combat Cancer
April 3, 2018
New research has identified the mechanisms responsible for enhancing immune system activity, offering new approaches for more effective cancer treatments and vaccines. Invariant natural killer T (iNKT) cells are part
ApoE4 Gene Variant and Alzheimer’s Disease Risk
April 1, 2018
Dr. Oliver Medvedik hosts the April 2018 edition of Journal Club, our monthly livestreamed event where we review and discuss the latest scientific research publications relating to life extension
Inflammaging and Age-related Disease
March 27, 2018
The aging process is accompanied by a chronic, smoldering background of inflammation that researchers call “inflammaging”. This backdrop of low-grade inflammation contributes significantly to mortality risk in the elderly and
Why NAD+ Declines With Age
March 19, 2018
Nicotinamide adenine dinucleotide (NAD+), a nucleotide, is critical for life to exist. From the most simple bacteria to complex multicellular organisms such as humans, NAD is a vital component of
Physical Activity Slows Aging of the Immune System
March 9, 2018
If you need yet another reason to exercise as part of your health and longevity strategy, then check out this study, which suggests that aging of the immune system can
Gene Cocktail Helps Hearts to Regenerate
March 2, 2018
The human heart is an organ whose cells rarely divide, making tissue repair and regeneration a huge problem following a heart attack. Many animals, such as zebrafish and salamanders, are
Researchers Discover How to Supercharge Stem Cells
February 27, 2018
Researchers at the School of Molecular Sciences at Arizona State University have discovered a potential way to supercharge our stem cells and reverse some aspects of cellular aging. The Hayflick
Caloric Restriction Improves Regeneration in Intestines
February 26, 2018
Caloric restriction has long been known to increase the lifespan and healthspan of most studied animals. Research also shows that animals given a calorie-restricted diet are also generally more able
Dentists May Soon Regenerate Teeth Using GSK3 Antagonists
February 9, 2018
What if I told you that we could regenerate our teeth? Well, that may soon be a possibility thanks to new research showing that teeth can be encouraged to regrow.
Alzheimer’s Reversed by Editing a Single Gene
May 24, 2018
Researchers at Gladstone Institutes in San Francisco report that a gene variant associated with Alzheimer’s works differently in mice and humans, and they also demonstrate how modifying this gene could potentially prevent the plaques associated with Alzheimer’s from forming and damaging the brain[1]. An ApoE4
NAD+ Regulates the Creation of Fat Cells
May 22, 2018
Researchers from the University of Texas have discovered how NAD+ creation and consumption in cells is linked to glucose metabolism and their transformation from preadipocytes into adipocytes, or as most people know them, fat cells. INTRODUCTION Nicotinamide adenine dinucleotide (NAD) is an essential small molecule that is
Recoding Human Cells to Make them Virus Proof
May 8, 2018
On May 1, around 200 scientists from the Genome Project-write (GP-write) met in Boston and announced the first target of their project: the creation of cells that cannot be infected by viruses. What is the Genome Project-write? GP-write includes sub-projects like the Human Genome Project-write (HGP-write),
Fasting might boost intestinal stem cell function
May 7, 2018
Stem cells supply the specialized cells that make up our tissues and organs; every time existing cells are lost for whatever reason, stem cells that can differentiate into that particular type of cell jump into action to compensate for the loss. However, this ability declines over
Using Peptides to Regrow Human Teeth
April 16, 2018
Researchers at the University of Washington have developed a therapy that uses peptides to promote the regrowth of tooth enamel in order to treat dental cavities. An end to tooth decay? There are multiple regenerative medicine approaches being developed to combat tooth decay; for example, earlier
Promising Results for Age-Related Macular Degeneration Trial
April 9, 2018
Researchers at the USC Roski Eye Institute, in collaboration with other institutions in California, have shown that a new stem cell-based retinal implant could help people with dry age-related macular degeneration [1]. The researchers have published the results of their phase 1/2a clinical trial in the
Activating Natural Killer T cells to Combat Cancer
April 3, 2018
New research has identified the mechanisms responsible for enhancing immune system activity, offering new approaches for more effective cancer treatments and vaccines. Invariant natural killer T (iNKT) cells are part of the immune system’s arsenal for fighting infection and defeating diseases like cancer. Finding ways to
ApoE4 Gene Variant and Alzheimer’s Disease Risk
April 1, 2018
Dr. Oliver Medvedik hosts the April 2018 edition of Journal Club, our monthly livestreamed event where we review and discuss the latest scientific research publications relating to life extension and aging. This month, we discuss the gene variant ApoE4, which raises the risk of Alzheimer’s
Inflammaging and Age-related Disease
March 27, 2018
The aging process is accompanied by a chronic, smoldering background of inflammation that researchers call “inflammaging”. This backdrop of low-grade inflammation contributes significantly to mortality risk in the elderly and has a number of sources. Today, we are going to take a look at inflammaging and
Why NAD+ Declines With Age
March 19, 2018
Nicotinamide adenine dinucleotide (NAD+), a nucleotide, is critical for life to exist. From the most simple bacteria to complex multicellular organisms such as humans, NAD is a vital component of cellular function and thus life. An increased level of NAD+ appears to convey health and longevity,
Physical Activity Slows Aging of the Immune System
March 9, 2018
If you need yet another reason to exercise as part of your health and longevity strategy, then check out this study, which suggests that aging of the immune system can be slowed by exercise. The problem with our modern lives is that we are, in general,
Gene Cocktail Helps Hearts to Regenerate
March 2, 2018
The human heart is an organ whose cells rarely divide, making tissue repair and regeneration a huge problem following a heart attack. Many animals, such as zebrafish and salamanders, are different; they can regenerate damaged hearts easily. As humans, we also once had the same regenerative
Researchers Discover How to Supercharge Stem Cells
February 27, 2018
Researchers at the School of Molecular Sciences at Arizona State University have discovered a potential way to supercharge our stem cells and reverse some aspects of cellular aging. The Hayflick limit Normal cells cannot divide indefinitely; they have a built-in replicative limit, which is often called
Caloric Restriction Improves Regeneration in Intestines
February 26, 2018
Caloric restriction has long been known to increase the lifespan and healthspan of most studied animals. Research also shows that animals given a calorie-restricted diet are also generally more able to regenerate tissue damage following injury. Caloric restriction improves tissue regeneration A new study by the
Dentists May Soon Regenerate Teeth Using GSK3 Antagonists
February 9, 2018
What if I told you that we could regenerate our teeth? Well, that may soon be a possibility thanks to new research showing that teeth can be encouraged to regrow. Rather than drilling holes into teeth and plugging them with artificial fillers, dentists in the near