Category: Research
Mutation Burden Explains Species’ Differences in Lifespan
April 15, 2022
In a study published in Nature, scientists have found an extremely strong correlation between somatic mutation rate and lifespan across several species, highlighting the importance of mutation burden for aging
Fundamental Protein Regulator Increases Lifespan in Flies
April 14, 2022
Increasing an important protein regulator improves the lifespan of Drosophila flies, according to a new paper published in Aging. Found in both animals and plants As the researchers explain, phosphatidylethanolamine-binding
One Cycle of Partial Reprogramming for Tissue Rejuvenation
April 13, 2022
Scientists have shown that a single cycle of partial cellular reprogramming leads to various changes in the tissues, but about half of them gradually disappear after the treatment [1]. Permanent
Senolytics Improve Resistance Training in Old Mice
April 11, 2022
A paper published in GeroScience has reported that older mice taking the well-known senolytic combination of dasatinib and quercetin (D+Q) are able to build muscle more like young mice. Senescent
Ginger Extract Shows Strong Senolytic Effect
April 8, 2022
A paper supported by the National Institute on Aging has shown that gingerenone A, a component of ginger extract, is a natural senolytic that is potentially more powerful and less
Results From A Human Trial Of Stem Cells For Alzheimer’s
April 7, 2022
A paper published in the journal of the Alzheimer’s Association has revealed the results of a Phase 1 clinical trial of stem cells for Alzheimer’s disease. Using stem cells for
Senolytics Restore α-Klotho in Mice and Humans
April 6, 2022
New senolytics data was released from Dr. James L. Kirkland’s Mayo Clinic lab and published in The Lancet [1]. Prior studies have shown that α-Klotho protein decreases with age in
New Candidate Drug Extends Lifespan in Male Mice
April 5, 2022
Scientists from Mayo Clinic have significantly extended lifespan in male mice by inhibiting the enzyme CD38, which lowers NAD levels [1]. The age-related decline of nicotinamide dinucleotide (NAD) has been
Corylin Shown to Affect Multiple Processes of Aging
April 4, 2022
A new publication in Nature Communications has revealed that corylin, which is derived from the Chinese herb Psoralea corylifolia, increases the lifespan of model organisms through well-known pathways of aging.
Metformin in Fathers Linked to Birth Defects
April 1, 2022
A large-cohort population study from Denmark has linked metformin to a 40% increase in the risk of birth defects when taken by fathers during the spermatozoa development period [1]. A
Caloric Consumption Affects Caloric Restriction in Mice
March 31, 2022
Publishing in Aging, researchers from the Chengdu Jinjiang Hospital in China have discovered that caloric restriction is less effective on mice previously fed a high-calorie diet. Well-known effects In their
Life Extension and Anti-Aging Have a Branding Problem
March 30, 2022
It seems bizarre that in 2022, some biotech companies interested in doing something about aging are still saying that they are not. Cellular rejuvenation seems to be the latest buzzword
Oleanoic Acid Protects Against Cardiac Aging in Mice
March 29, 2022
Scientists have shown that oleanoic acid, a nutrient most associated with olive oil, greatly improves numerous markers of cardiac health in aging mice [1]. is a nutrient abundant in some
A Common Amyloid Between Brain Diseases
March 28, 2022
Research funded by the National Institutes of Health and published in Cell has thoroughly described a little-known amyloid aggregate that accumulates in the brains of people suffering from multiple proteostasis-related
Anti-Inflammatory Diet Lowers Risk of Dementia
March 25, 2022
In a population study, scientists have found that consuming foods associated with a low Diet Inflammatory Index substantially lowers the risk of dementia [1]. Aging is accompanied by an increase
Mutation Burden Explains Species’ Differences in Lifespan
April 15, 2022
In a study published in Nature, scientists have found an extremely strong correlation between somatic mutation rate and lifespan across several species, highlighting the importance of mutation burden for aging [1]. The question of why lifespan varies so vastly among species, including closely related ones, has
Fundamental Protein Regulator Increases Lifespan in Flies
April 14, 2022
Increasing an important protein regulator improves the lifespan of Drosophila flies, according to a new paper published in Aging. Found in both animals and plants As the researchers explain, phosphatidylethanolamine-binding proteins (PEBPs) are present in both plant and animal cells. These proteins are critical to multiple
One Cycle of Partial Reprogramming for Tissue Rejuvenation
April 13, 2022
Scientists have shown that a single cycle of partial cellular reprogramming leads to various changes in the tissues, but about half of them gradually disappear after the treatment [1]. Permanent or transient? It has been known since 2006 that somatic cells can be reverted to a
Senolytics Improve Resistance Training in Old Mice
April 11, 2022
A paper published in GeroScience has reported that older mice taking the well-known senolytic combination of dasatinib and quercetin (D+Q) are able to build muscle more like young mice. Senescent cells harm muscle development In this paper, the researchers cite their prior research showing that the
Ginger Extract Shows Strong Senolytic Effect
April 8, 2022
A paper supported by the National Institute on Aging has shown that gingerenone A, a component of ginger extract, is a natural senolytic that is potentially more powerful and less toxic than the combination of dasatinib and quercetin [1]. Ginger and many other plants are widely
Results From A Human Trial Of Stem Cells For Alzheimer’s
April 7, 2022
A paper published in the journal of the Alzheimer’s Association has revealed the results of a Phase 1 clinical trial of stem cells for Alzheimer’s disease. Using stem cells for their signals While stem cells, including the mesenchymal stem cells (MSCs) of which Lomecel-B consists, are
Senolytics Restore α-Klotho in Mice and Humans
April 6, 2022
New senolytics data was released from Dr. James L. Kirkland’s Mayo Clinic lab and published in The Lancet [1]. Prior studies have shown that α-Klotho protein decreases with age in mice and humans [2,3]. It has also been demonstrated that mice that lack α-Klotho have shorter
New Candidate Drug Extends Lifespan in Male Mice
April 5, 2022
Scientists from Mayo Clinic have significantly extended lifespan in male mice by inhibiting the enzyme CD38, which lowers NAD levels [1]. The age-related decline of nicotinamide dinucleotide (NAD) has been associated with various metabolic abnormalities, age-related diseases, and fitness loss. Increasing NAD levels is considered a
Corylin Shown to Affect Multiple Processes of Aging
April 4, 2022
A new publication in Nature Communications has revealed that corylin, which is derived from the Chinese herb Psoralea corylifolia, increases the lifespan of model organisms through well-known pathways of aging. Finding corylin This study did not begin with an examination of corylin or even a look
Metformin in Fathers Linked to Birth Defects
April 1, 2022
A large-cohort population study from Denmark has linked metformin to a 40% increase in the risk of birth defects when taken by fathers during the spermatozoa development period [1]. A drug linked to longevity Metformin is an anti-diabetes drug that drew geroscientists’ attention after studies had
Caloric Consumption Affects Caloric Restriction in Mice
March 31, 2022
Publishing in Aging, researchers from the Chengdu Jinjiang Hospital in China have discovered that caloric restriction is less effective on mice previously fed a high-calorie diet. Well-known effects In their introduction, the researchers discuss what caloric restriction is known to do, citing papers that show its
Life Extension and Anti-Aging Have a Branding Problem
March 30, 2022
It seems bizarre that in 2022, some biotech companies interested in doing something about aging are still saying that they are not. Cellular rejuvenation seems to be the latest buzzword and an attempt to rebrand and escape the stigma of anti-aging. Genentech is another cellular rejuvenation
Oleanoic Acid Protects Against Cardiac Aging in Mice
March 29, 2022
Scientists have shown that oleanoic acid, a nutrient most associated with olive oil, greatly improves numerous markers of cardiac health in aging mice [1]. is a nutrient abundant in some foods, particularly olive oil. Olive oil has been shown to have health benefits compared to most
A Common Amyloid Between Brain Diseases
March 28, 2022
Research funded by the National Institutes of Health and published in Cell has thoroughly described a little-known amyloid aggregate that accumulates in the brains of people suffering from multiple proteostasis-related neurological disorders. Three classes of pathology, one protein fragment The authors of this study list three
Anti-Inflammatory Diet Lowers Risk of Dementia
March 25, 2022
In a population study, scientists have found that consuming foods associated with a low Diet Inflammatory Index substantially lowers the risk of dementia [1]. Aging is accompanied by an increase in chronic, low-grade inflammation, known as inflammaging, which has been linked to multiple age-related diseases. Inflammaging