Category: Research
Ask the PEARL Team Anything!
May 28, 2021
Today, we want to announce we are doing an AMA on Reddit Futurology! The Ask Me Anything thread will be open May 28 and 29 for pre-questions, and on May
Long Non-Coding RNAs as an Alternative to Senolytics
May 27, 2021
New research has identified a set of long noncoding RNAs involved in inflammaging and the senescence-associated secretory phenotype (SASP) [1]. These RNAs are conserved across a range of species, including
Oisín Announces $5 Million in New Seed Funding
May 27, 2021
Today, Oisín Biotechnologies, a well-known developer of senolytics, drugs that destroy harmful senescent cells, has announced that it has more than doubled its total funding through an oversubscribed round. This
Cytosolic dsDNA as a Marker of Senescence
May 26, 2021
Senescent cells are surprisingly hard to identify, but a recent publication in Tissue and Cell makes the case for using cytoplasmic DNA as a marker of senescence. What makes a
Overwork Linked to Heart Disease and Stroke
May 25, 2021
In the largest study of its kind to date, researchers have revealed that a considerable part of all deaths from ischemic heart disease and stroke worldwide is caused by working
OSKM in Early Life Increases Lifespan in Mice
May 24, 2021
An article preprint published on bioRxiv shows that a single OSKM treatment in early life provides lifelong benefits in mice. A single reset versus lifetime resetting The team chose a
Human Trials of mTOR Inhibitors for Immune Aging
May 21, 2021
A new study published in The Lancet shows the results of Phase 2a and Phase 3 clinical trials for the effectiveness of mTOR inhibition to bolster the aging immune system
Move Beyond the Hallmarks, Urges New Paper
May 20, 2021
The hallmarks of aging, as presented in a 2013 paper [1], have been useful but do not provide a genuine explanatory paradigm, argue David Gems of University College London and
Deep Longevity Partners With LifeHub & LifeClinic
May 18, 2021
Today, we have a bit more positive news with the announcement that Deep Longevity has added LifeHub and LifeClinic to its network of longevity-focused companies. This company plans to use
Nicotinamide Riboside Rejuvenates Blood Stem Cells in Mice
May 18, 2021
Researchers have reversed the age-related decline in the function of hematopoietic stem cells (HSCs) in older mice using nicotinamide riboside. This success can make our blood more youthful and increase
SIRT6 Linked to Slower Aging in Mice
May 17, 2021
A study published in Aging has shown that the sirtuin SIRT6 has positive effects on multiple hallmarks of aging in the hearts of mice. Sirtuins Sirtuins are a family of
Why Quality Sleep Should Be Part of Your Longevity Strategy
May 13, 2021
Quality sleep is one of the foundations of health, and a new study suggests that poor sleep quality is a major risk factor for developing Alzheimer’s disease and other dementias.
Intermittent Fasting During Ramadan Alters Gut Bacteria
May 13, 2021
Intermittent fasting changes the composition of the gut microbiome, according to new research [1]. An increase in the abundance of a group of bacteria known as Lachnospiraceae may explain some
DHE Reduces Inflammation, Senescence in Intervertebral Discs
May 12, 2021
Recent research out of Frontiers in Pharmacology has shown that a natural herbal compound reduces senescence and intervertebral disc degeneration in mice. Cellular senescence in intervertebral disc degeneration Located between
Some People think Life Extension is “Just a Fear of Death”
May 11, 2021
Sometimes those working in the field of rejuvenation biotechnology face the accusation that what they are doing is just a fear of death, like not being scared of age-related diseases
Ask the PEARL Team Anything!
May 28, 2021
Today, we want to announce we are doing an AMA on Reddit Futurology! The Ask Me Anything thread will be open May 28 and 29 for pre-questions, and on May 30 and 31, the PEARL team will be answering questions. This is your opportunity to ask
Long Non-Coding RNAs as an Alternative to Senolytics
May 27, 2021
New research has identified a set of long noncoding RNAs involved in inflammaging and the senescence-associated secretory phenotype (SASP) [1]. These RNAs are conserved across a range of species, including humans, and may prove a valuable avenue for controlling senescence. Age-related RNAs RNA can broadly be
Oisín Announces $5 Million in New Seed Funding
May 27, 2021
Today, Oisín Biotechnologies, a well-known developer of senolytics, drugs that destroy harmful senescent cells, has announced that it has more than doubled its total funding through an oversubscribed round. This has taken its total funding from $4.5 million to $9.5 million. Named after a legendary Irish
Cytosolic dsDNA as a Marker of Senescence
May 26, 2021
Senescent cells are surprisingly hard to identify, but a recent publication in Tissue and Cell makes the case for using cytoplasmic DNA as a marker of senescence. What makes a cell senescent? In order to study the behavior of senescent cells, or to treat them with
Overwork Linked to Heart Disease and Stroke
May 25, 2021
In the largest study of its kind to date, researchers have revealed that a considerable part of all deaths from ischemic heart disease and stroke worldwide is caused by working long hours [1]. Beware of Karoshi What can we do to live longer until science can
OSKM in Early Life Increases Lifespan in Mice
May 24, 2021
An article preprint published on bioRxiv shows that a single OSKM treatment in early life provides lifelong benefits in mice. A single reset versus lifetime resetting The team chose a group of heterozygous progeric mice as a mouse model. These mice suffer from a single mutation
Human Trials of mTOR Inhibitors for Immune Aging
May 21, 2021
A new study published in The Lancet shows the results of Phase 2a and Phase 3 clinical trials for the effectiveness of mTOR inhibition to bolster the aging immune system against respiratory illnesses. Immunosenescence increases disease risk As we grow older, our immune systems become increasingly
Move Beyond the Hallmarks, Urges New Paper
May 20, 2021
The hallmarks of aging, as presented in a 2013 paper [1], have been useful but do not provide a genuine explanatory paradigm, argue David Gems of University College London and João Pedro de Magalhães of the University of Liverpool in a pre-print paper [2]. They propose
Deep Longevity Partners With LifeHub & LifeClinic
May 18, 2021
Today, we have a bit more positive news with the announcement that Deep Longevity has added LifeHub and LifeClinic to its network of longevity-focused companies. This company plans to use multiple AI-based biological aging clocks to test a variety of longevity interventions, including supplements, drugs, and
Nicotinamide Riboside Rejuvenates Blood Stem Cells in Mice
May 18, 2021
Researchers have reversed the age-related decline in the function of hematopoietic stem cells (HSCs) in older mice using nicotinamide riboside. This success can make our blood more youthful and increase the effectiveness of stem cell transplantation [1]. There will be blood HSCs are the progenitors of
SIRT6 Linked to Slower Aging in Mice
May 17, 2021
A study published in Aging has shown that the sirtuin SIRT6 has positive effects on multiple hallmarks of aging in the hearts of mice. Sirtuins Sirtuins are a family of proteins that have been shown to have significant effects on longevity in multiple model organisms. In
Why Quality Sleep Should Be Part of Your Longevity Strategy
May 13, 2021
Quality sleep is one of the foundations of health, and a new study suggests that poor sleep quality is a major risk factor for developing Alzheimer’s disease and other dementias. Dementia is a rising global problem Worldwide, close to fifty million people currently live with Alzheimer’s
Intermittent Fasting During Ramadan Alters Gut Bacteria
May 13, 2021
Intermittent fasting changes the composition of the gut microbiome, according to new research [1]. An increase in the abundance of a group of bacteria known as Lachnospiraceae may explain some of the health benefits linked with dietary restriction. A natural experiment Intermittent fasting—the repeated, severe restriction
DHE Reduces Inflammation, Senescence in Intervertebral Discs
May 12, 2021
Recent research out of Frontiers in Pharmacology has shown that a natural herbal compound reduces senescence and intervertebral disc degeneration in mice. Cellular senescence in intervertebral disc degeneration Located between our vertebral bones, intervertebral discs are the shock-absorbing tissues that allow the spine to bend. Like
Some People think Life Extension is “Just a Fear of Death”
May 11, 2021
Sometimes those working in the field of rejuvenation biotechnology face the accusation that what they are doing is just a fear of death, like not being scared of age-related diseases is somehow brave. War used to be fashionable but now it isn’t These days, war is