Category: Research
Boosting Cellular Housekeeping with Exercise and Fasting
February 28, 2019
In order to remain healthy and functional, cells have a number of maintenance systems that help them to dispose of metabolic waste and unwanted proteins. Autophagy is perhaps the best-known
Excessive Cell Size Contributes to Senescence
February 19, 2019
In a new study [1], researchers have identified the reason why cells become defective when they grow too large and why protein creation fails when cells grow larger than their
New Aging Clock Accurately Predicts Biological Age
February 15, 2019
Researchers at the Harvard T.H. Chan School of Public Health have discovered a new aging clock that can accurately determine both chronological and biological age in a wide variety of
Removing Senescent Cells Improves Heart Health
February 11, 2019
Researchers at Newcastle University have shown that clearing out senescent cardiac muscle cells from the hearts of aged mice restores heart health. It seems that not a month goes by
New Aging Clock Could Predict Your Future Lifespan
January 31, 2019
A new aging clock developed by Professor Steve Horvath and his research team takes measuring your biological age a step further and can accurately predict your future lifespan. The epigenetic
The American Public Increasingly Desires Life Extension
January 28, 2019
While medical schools have had the idea that aging should be brought under medical control for over a century, the explicit desire to greatly extend one’s life remained rare –
The Gut Microbiome of Healthy, Long-Lived People
January 23, 2019
A new study has outlined the age-related changes of the gut microbiome, showing a correlation between the microbiome’s composition and overall health. The gut microbiome The microbiome describes a varied
UNITY Biotechnologies Selects a New Senolytic Candidate
January 14, 2019
Another senolytic drug candidate has entered development at Unity Biotechnologies. The purpose of senolytics is to clear the body of harmful senescent cells, which accumulate with age and encourage age-related
NAD+ Enters Cells via Newly Discovered Pathway
January 9, 2019
A new study published in Nature Metabolism finally reveals the answer to how NMN enters the cell in order to become NAD+ and that it does not need to be
Human Pilot Study Results for Senolytics Published
January 7, 2019
The results from a human pilot study that focused on treating idiopathic pulmonary fibrosis with senescent cell-clearing drugs has been published. The drugs target aged and damaged cells, which are
Fisetin May be a Low-Hanging Fruit for Aging
December 26, 2018
There has been considerable interest in fisetin recently, especially for its potential as a senolytic, which clears away dysfunctional senescent cells that accumulate with aging. Researchers believe that fisetin may
Therapies Targeting Aging are in Human Trials Now
December 10, 2018
A number of therapies that directly target the aging processes are currently in human trials and could change medicine significantly in the next decade if the results are positive. What
Human Stem Cell Trial Successful Against Age-Related Frailty
December 7, 2018
Today, we want to highlight results from human trials in which stem cell transplants have been shown to reduce age-related frailty. Age-related frailty and stem cell transplants Currently, there are
A Review of Fasting and Calorie Restriction
November 28, 2018
Today, we want to discuss a review published in the journal Science, as it provides a whistle-stop tour of caloric restriction, intermittent fasting, and time-restricted feeding [1]. There is a
Too much mTOR is Linked to Diabetes and Aging
November 15, 2018
A new study takes a look at the relationship between metabolism, aging, and type 2 diabetes and in particular the mTORC1 protein complex, part of the mTOR pathway. The mTOR
Boosting Cellular Housekeeping with Exercise and Fasting
February 28, 2019
In order to remain healthy and functional, cells have a number of maintenance systems that help them to dispose of metabolic waste and unwanted proteins. Autophagy is perhaps the best-known example of how cells purge their waste, and another is the ubiquitin-proteasome system (UPS). Researchers are
Excessive Cell Size Contributes to Senescence
February 19, 2019
In a new study [1], researchers have identified the reason why cells become defective when they grow too large and why protein creation fails when cells grow larger than their original healthy size, as is typically seen in aged and senescent cells. They demonstrate that in
New Aging Clock Accurately Predicts Biological Age
February 15, 2019
Researchers at the Harvard T.H. Chan School of Public Health have discovered a new aging clock that can accurately determine both chronological and biological age in a wide variety of species. Aging and the nucleolus There are two kinds of age: chronological age, which is strictly
Removing Senescent Cells Improves Heart Health
February 11, 2019
Researchers at Newcastle University have shown that clearing out senescent cardiac muscle cells from the hearts of aged mice restores heart health. It seems that not a month goes by without a new study showing that senolytics, drugs that remove aged and damaged cells from the
New Aging Clock Could Predict Your Future Lifespan
January 31, 2019
A new aging clock developed by Professor Steve Horvath and his research team takes measuring your biological age a step further and can accurately predict your future lifespan. The epigenetic clock As we age, our DNA experiences chemical changes called DNA methylation (DNAm); these changes are
The American Public Increasingly Desires Life Extension
January 28, 2019
While medical schools have had the idea that aging should be brought under medical control for over a century, the explicit desire to greatly extend one’s life remained rare – until very recently. A new study by YouGov, a market intelligence company that researches multiple topics,
The Gut Microbiome of Healthy, Long-Lived People
January 23, 2019
A new study has outlined the age-related changes of the gut microbiome, showing a correlation between the microbiome’s composition and overall health. The gut microbiome The microbiome describes a varied community of bacteria, archaea, eukarya, and viruses that inhabit our gut. The four bacterial phyla of
UNITY Biotechnologies Selects a New Senolytic Candidate
January 14, 2019
Another senolytic drug candidate has entered development at Unity Biotechnologies. The purpose of senolytics is to clear the body of harmful senescent cells, which accumulate with age and encourage age-related diseases to develop. A new treatment for age-related diseases of the eye Recently, UNITY Biotechnologies announced
NAD+ Enters Cells via Newly Discovered Pathway
January 9, 2019
A new study published in Nature Metabolism finally reveals the answer to how NMN enters the cell in order to become NAD+ and that it does not need to be converted into NR to do so. In the last few years, there has been considerable interest
Human Pilot Study Results for Senolytics Published
January 7, 2019
The results from a human pilot study that focused on treating idiopathic pulmonary fibrosis with senescent cell-clearing drugs has been published. The drugs target aged and damaged cells, which are thought to be a reason we age and get sick, and remove them from the body.
Fisetin May be a Low-Hanging Fruit for Aging
December 26, 2018
There has been considerable interest in fisetin recently, especially for its potential as a senolytic, which clears away dysfunctional senescent cells that accumulate with aging. Researchers believe that fisetin may be useful in increasing the healthy period of life known as healthspan. What is Fisetin? Fisetin
Therapies Targeting Aging are in Human Trials Now
December 10, 2018
A number of therapies that directly target the aging processes are currently in human trials and could change medicine significantly in the next decade if the results are positive. What is aging? Aging is basically the accumulation of damage and errors caused by a collection of
Human Stem Cell Trial Successful Against Age-Related Frailty
December 7, 2018
Today, we want to highlight results from human trials in which stem cell transplants have been shown to reduce age-related frailty. Age-related frailty and stem cell transplants Currently, there are no specific approved therapies to address age-related frailty, which can cause elderly people to suffer potentially
A Review of Fasting and Calorie Restriction
November 28, 2018
Today, we want to discuss a review published in the journal Science, as it provides a whistle-stop tour of caloric restriction, intermittent fasting, and time-restricted feeding [1]. There is a considerable amount of data supporting the effects of caloric restriction and similar dietary approaches on both
Too much mTOR is Linked to Diabetes and Aging
November 15, 2018
A new study takes a look at the relationship between metabolism, aging, and type 2 diabetes and in particular the mTORC1 protein complex, part of the mTOR pathway. The mTOR pathway The mechanistic target of rapamycin (mTOR) pathway is a major part of metabolism and is