Tag: Brain

A new study calls for caution in using the well-known senolytic treatment of dasatinib and quercetin (D+Q), showing that it causes damage in certain regions of the brain, similar to what is observed in multiple sclerosis [1]. Stem cell senescence prevents brain repair Multiple sclerosis (MS) is a brain disorder in which the patient’s own...

The pro-Alzheimer's allele APOE4 makes hippocampal neurons in mice smaller and hyperexcitable. This effect, which resembles epilepsy and accelerated aging, can be mitigated by manipulating a neuronal protein [1]. Before symptoms arise Alzheimer's disease begins long before symptoms appear, building silently for decades. The single strongest genetic risk factor for the common, late-onset form of...

Researchers have discovered a potential treatment for post-operative delirium, which accelerates cognitive decline in older people. A common problem with long-term effects Roughly a quarter of older people suffer from delirium after surgery [1], which rises to around half if the surgery is particularly invasive or high-risk [2]. This increases the length of hospital stays...

A new study suggests that microbiome remodeling is a mechanism behind age-related cognitive decline, with one particular bacterial species identified as the likely culprit. In mice, antibiotics seem to reverse this effect [1]. The gut-brain axis and the microbiome Memory decline is a common and debilitating feature of aging, but its mechanisms remain poorly understood....

In a new study, researchers have vitrified mouse brain slices and then a complete brain with encouraging results: upon rewarming, much of the neuronal function was preserved [1]. The bumpy road to cryopreservation Successful cryopreservation is a coveted prize in medicine, as cryopreserving organs and tissues can make transplantation more accessible. It is also a...

Using brain clock models that analyzed MRI images of the brains of elderly people who underwent one year of resistance training, researchers concluded that both heavy and moderate resistance training slow brain aging [1]. The broad benefits Exercise has been linked to many benefits, such as lowering blood pressure, slowing down cancer progression, preventing fitness...