Tag: Inflammaging

An investigation into the aging immune system identified age-related changes, including sex-dependent differences, in immune cell subpopulations and gene expression. In general, females showed greater age-related changes than males, including greater changes in autoimmune gene expression [1]. Cell-by-cell analysis Aging results in changes to the function and composition of immune cells, collectively referred to as...

A paper in Cell Genomics has described how age-related systemic inflammation (inflammaging) is related to epigenetic aging as measured by four established clocks. Tying together two well-known aspects of aging Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into the body without the drama of an infection or obvious...

In Aging Cell, researchers have described how the enzyme Pck1, a core part of metabolic activity, is required for staving off senescence in fat (adipose) cells. The aging of fat With the decrease in metabolic activity that frequently occurs with aging, human beings often accumulate fat. This fat, itself, also ages; this paper describes it...

Researchers publishing in Aging Cell have discovered how older organisms' susceptibility to pneumonia is related to inflammatory factors. Short-lived infection fighters Polymorphonuclear leukocytes, more commonly known as neutrophils, are part of the first line of defense against lung infections. Illnesses cause these immune cells to be recruited from the bone marrow in a process called...

Researchers publishing in Aging Cell have found that Hevin, a protein found in the extracellular matrix that increases with age, leads to heart problems in older male mice. Inflammaging contributes to heart disease Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into the body without the drama of an...

In Nature Aging, researchers have discovered growth differentiation factor 3 (GDF3), a cytokine that increases with aging, is related to more inflammatory macrophages in older animals. Fat and inflammation We have recently reported on a potential treatment for visceral fat, as this kind of fat is known to generate health problems, including an increase in...