Tag: Omics

In a new study, metformin, which has already shown good results in rodents and in human epidemiological studies, alleviated multiple signs of aging in male cynomolgus monkeys [1]. Now in monkeys Metformin, a well-established anti-diabetes drug, has been touted as a possible geroprotector since a study suggested that diabetes patients on metformin outlived age-matched healthy...

New research in Aging Cell has suggested that targeting senescent cells based on their surface proteins (surfaceome) may be effective in dealing with them. Focusing on what's easiest to target Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which...

Assisted by TruDiagnostic, a team of researchers has published a preprint paper in which omics data has been used to create an epigenetic methylation clock. Why -omics? Epigenetic Clocks - What are they?An epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA to determine biological age....

As explained in a paper published in GeroScience, researchers have used spatial transcriptomic analysis to show the inflammatory nodes that are caused by brain cells undergoing senescence. What is spatial transcriptomic analysis? Spatial transcription analysis isn't a full 3D view of an entire brain. Rather, it is based on a series of slides of mouse...

A new preprint on bioRxiv shows how researchers have developed transcriptomic, cell type specific aging clocks from the regenerative zones of mouse brains [1]. Measuring age at the level of a single cell Aging is multi-faceted and difficult to quantify. While chronological age is straightforward, it doesn’t necessarily capture the underlying biology, as individuals naturally...

The latest research in Aging Cell has brought to light new insights into the biology of aging and associated therapeutic candidates. What is multi-omics? "-omics" refers to branches of molecular biology that attempt to characterize and/or quantify their components in totality, often using recently developed big data technologies. For example, genetics is the study of...