Tag: Senolytics

A new study calls for caution in using the well-known senolytic treatment of dasatinib and quercetin (D+Q), showing that it causes damage in certain regions of the brain, similar to what is observed in multiple sclerosis [1]. Stem cell senescence prevents brain repair Multiple sclerosis (MS) is a brain disorder in which the patient’s own...

Cellular senescence, a state in which cells stop dividing but resist dying, accumulating in tissues over time, has emerged as one of the most promising targets in longevity medicine. Senescent cells actually serve important roles in development, wound healing, and cancer prevention, but as they accumulate with age or pathology, they become harmful: they secrete...

Researchers publishing in Nature Aging have described how mitochondrial stress is a key part of why senolytics are effective. Finding targeted effectiveness What Are Senolytics? Senotherapeutics for Senescent CellsSenolytics work by targeting one of several pro-survival pathways that senescent cells use to evade apoptosis and cling onto life. One of the challenges in dealing with...

A recent study reported that the effectiveness of the senotherapeutic drug ABT-263 depends on the cell’s DNA content, which is based on the cell cycle phase at which the senescent cell was arrested [1]. A personalized approach Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support...

Recent commentary in Nature Aging summarized the results of clinical trials for senolytics and discussed recommendations for future clinical trials that use personalized medicine approaches [1]. From basic science to clinical trials Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they...

Researchers have found that inflamed, senescent microglia prune too many synapses in the hippocampus and demonstrated that a senolytic compound can ameliorate this process in Aging Cell. Some synapse pruning is normal During brain development, the resident immune cells of the brain (microglia) prune unneeded synapses as a form of maintenance. This is normally a...