Category: News
Extracellular Vesicles for Treating Arthritis
November 7, 2024
A study in Pharmacological Research has found that small extracellular vesicles derived from embryonic stem cells (ESC-sEVs) alleviate osteoarthritis in cells and mice. Restoring senescent cells’ function Excessive senescent cell
Mesenchymal Stem Cells Rejuvenate Aged Mice
November 6, 2024
In a new study, the researchers administered human umbilical cord-derived mesenchymal stem cells (HUCMSCs) to aged mice and observed reduced degeneration in multiple organs, changes to microbial composition, metabolic alterations,
Ketogenic Diet Effective Against Multiple Sclerosis in Mice
November 5, 2024
Scientists have found that both a ketogenic diet and oral supplementation with ketone bodies alleviate symptoms of multiple sclerosis, a serious autoimmune disorder, in a mouse model [1]. Keto and
Towards Fine-Tuned Control of Gene Expression
November 4, 2024
In a groundbreaking Nature paper, researchers have developed synthetic regulatory sequences that could prevent targeted gene therapies from having effects in unwanted cell types. More than methylation While methylation is
New Crowdfunding Project Looks for a “Better Rapamycin”
November 1, 2024
Ora Biomedical and the Rapamycin Longevity Lab have launched a project to screen more than 600 mTOR inhibitors in the hope of finding some that are superior to geroscience’s poster
Rejuvenation Roundup October 2024
November 1, 2024
The trick-or-treaters have all gotten their candy, but age-related diseases haunt us still. Here’s what we’ve learned about them in October. LEAF News Team and activities Fall Is Here, but
Senescent Cells Promote Cartilage Regeneration in Rats
October 31, 2024
In a rat experiment, researchers publishing in Aging Cell have found that senescent cells and SASP factors are key in regenerating knee cartilage. Not always negative Cellular senescence is widely
NOVOS Supplement: Lifespan Extension in Male Mice
October 30, 2024
A recent preprint study suggests that a NOVOS supplement can improve healthspan and extend lifespan in male mice [1]. Multiple ingredients, one goal This preprint’s authors start by discussing dietary
Life Biosciences Is Bringing Reprogramming to the Clinic
October 29, 2024
Life Biosciences is a company co-founded by the celebrity geroscientist David Sinclair and is based on his Harvard team’s research into partial cellular reprogramming. In the heated race to translate
The Fibroblasts That Protect Ovarian Cancer
October 28, 2024
In Aging, researchers have described a subpopulation of fibroblasts that nurture ovarian cancer tumors and shield them from harm. Cancer’s natural defenders Ovarian cancer is particularly dangerous, both in death
Neuronal Reprogramming Alleviates Alzheimer’s in Mice
October 25, 2024
Scientists have shown that long-term intermittent reprogramming limited to hippocampal neurons increases their fitness and improves cognitive function in a mouse model of Alzheimer’s disease [1]. Targeted in time and
A Senolytic Treatment for Liver Sepsis
October 24, 2024
A paper published in Aging Cell offers evidence for the idea that senolytics might be a treatment for acute liver sepsis. A deadly condition linked to a hallmark of aging
HAPLN1 in Blood Found to Rejuvenate Skin
October 23, 2024
Investigating the factors involved in skin rejuvenation processes, researchers have identified the role of hyaluronan and proteoglycan link protein 1 (HAPLN1) in restoring collagen and hyaluronic acid in aged skin
Autodigestion From Gut Enzymes May Drive Aging
October 22, 2024
A new study links damage caused by digestive enzymes escaping from the gut to several hallmarks of aging. The researchers dubbed this effect “autodigestion.” [1] Don’t eat yourself up! To
The Reason Why the p16 Senescence Pathway Exists
October 21, 2024
Researchers publishing in Aging Cell have investigated the biology of skin cells taken from people who don’t produce the senescence-related compound p16. A necessary evil The aging community has published
Extracellular Vesicles for Treating Arthritis
November 7, 2024
A study in Pharmacological Research has found that small extracellular vesicles derived from embryonic stem cells (ESC-sEVs) alleviate osteoarthritis in cells and mice. Restoring senescent cells’ function Excessive senescent cell buildup in cartilage has negative effects and leads to osteoarthritis [1]. Constant exposure to SASP factors
Mesenchymal Stem Cells Rejuvenate Aged Mice
November 6, 2024
In a new study, the researchers administered human umbilical cord-derived mesenchymal stem cells (HUCMSCs) to aged mice and observed reduced degeneration in multiple organs, changes to microbial composition, metabolic alterations, improvements in behavior and ability, and reduced fearfulness [1]. Therapeutic potential Earlier this year, we reported
Ketogenic Diet Effective Against Multiple Sclerosis in Mice
November 5, 2024
Scientists have found that both a ketogenic diet and oral supplementation with ketone bodies alleviate symptoms of multiple sclerosis, a serious autoimmune disorder, in a mouse model [1]. Keto and autoimmune diseases In ketogenic diets, the vast majority of calories are derived from fat, some from
Towards Fine-Tuned Control of Gene Expression
November 4, 2024
In a groundbreaking Nature paper, researchers have developed synthetic regulatory sequences that could prevent targeted gene therapies from having effects in unwanted cell types. More than methylation While methylation is the most well-known regulator of gene expression, it isn’t the only thing that determines what is
New Crowdfunding Project Looks for a “Better Rapamycin”
November 1, 2024
Ora Biomedical and the Rapamycin Longevity Lab have launched a project to screen more than 600 mTOR inhibitors in the hope of finding some that are superior to geroscience’s poster child, rapamycin. Better than chance Rapamycin, one of the most potent compounds for prolonging lifespan in
Rejuvenation Roundup October 2024
November 1, 2024
The trick-or-treaters have all gotten their candy, but age-related diseases haunt us still. Here’s what we’ve learned about them in October. LEAF News Team and activities Fall Is Here, but It’s Full Steam Ahead for Lifespan.io: For those of us living in the Northern Hemisphere, the
Senescent Cells Promote Cartilage Regeneration in Rats
October 31, 2024
In a rat experiment, researchers publishing in Aging Cell have found that senescent cells and SASP factors are key in regenerating knee cartilage. Not always negative Cellular senescence is widely known to have negative effects, to the point that it is one of the hallmarks of
NOVOS Supplement: Lifespan Extension in Male Mice
October 30, 2024
A recent preprint study suggests that a NOVOS supplement can improve healthspan and extend lifespan in male mice [1]. Multiple ingredients, one goal This preprint’s authors start by discussing dietary supplements’ beneficial effects on lifespan and markers of healthspan in multiple organisms and their possible additive
Life Biosciences Is Bringing Reprogramming to the Clinic
October 29, 2024
Life Biosciences is a company co-founded by the celebrity geroscientist David Sinclair and is based on his Harvard team’s research into partial cellular reprogramming. In the heated race to translate this promising technology to the clinic, Life has emerged as one of the favorites, inching closer
The Fibroblasts That Protect Ovarian Cancer
October 28, 2024
In Aging, researchers have described a subpopulation of fibroblasts that nurture ovarian cancer tumors and shield them from harm. Cancer’s natural defenders Ovarian cancer is particularly dangerous, both in death rates and in recurrence [1]. Normally, chemicals that contain platinum are effective, but this sort of
Neuronal Reprogramming Alleviates Alzheimer’s in Mice
October 25, 2024
Scientists have shown that long-term intermittent reprogramming limited to hippocampal neurons increases their fitness and improves cognitive function in a mouse model of Alzheimer’s disease [1]. Targeted in time and space Partial cellular reprogramming is one of the hottest directions in longevity research for a reason:
A Senolytic Treatment for Liver Sepsis
October 24, 2024
A paper published in Aging Cell offers evidence for the idea that senolytics might be a treatment for acute liver sepsis. A deadly condition linked to a hallmark of aging Sepsis, an inflammatory condition most commonly known as blood poisoning, is the most common cause of
HAPLN1 in Blood Found to Rejuvenate Skin
October 23, 2024
Investigating the factors involved in skin rejuvenation processes, researchers have identified the role of hyaluronan and proteoglycan link protein 1 (HAPLN1) in restoring collagen and hyaluronic acid in aged skin [1]. The most noticeable sign of aging Skin aging, one of the most visible forms of
Autodigestion From Gut Enzymes May Drive Aging
October 22, 2024
A new study links damage caused by digestive enzymes escaping from the gut to several hallmarks of aging. The researchers dubbed this effect “autodigestion.” [1] Don’t eat yourself up! To live, we must eat, which involves breaking down compounds that we ourselves consist of, such as
The Reason Why the p16 Senescence Pathway Exists
October 21, 2024
Researchers publishing in Aging Cell have investigated the biology of skin cells taken from people who don’t produce the senescence-related compound p16. A necessary evil The aging community has published a lot of papers on p16INK4a (p16) and its SASP-associated dangers, as excessive SASP production is