Category: News
Targeting Metabolism To Slow Down Aging
January 31, 2022
Publishing in Aging, a group of Korean researchers has discovered a compound that affects the way our mitochondria process energy, ameliorating cellular senescence. A deep dive into biochemistry To begin
Sonia Arrison: “Aging Is One of the Last Unifying Issues”
January 31, 2022
Sonia Arrison is an entrepreneur, investor, and best-selling author. Her book “100 Plus: How the Coming Age of Longevity Will Change Everything”, published in 2011, was one of the first
A New Startup Is Going After Rogue Cells
January 28, 2022
In a blog post, the founder and CEO of Arda Therapeutics, Adam Freund, explained his company’s intriguing strategy along with why it is imperative to counter aging. From Calico to
Senolytics Restore Cognitive Ability in Aged Rats
January 27, 2022
Polish researchers publishing in Aging have discovered that the well-known senolytic combination of dasatinib and quercetin improves the cognitive capabilities of older rats. Understanding neuroplasticity While new neurons can be
Dietary Fiber and Probiotics Affect Melanoma Immunotherapy
January 26, 2022
A study published in Science by Dr. Jennifer A. Wargo and her colleagues spanning multiple centers recently examined if dietary fiber and commercially available probiotics affect immunotherapy response in cancer
Meta-Analysis Discovers Goldilocks Zone for IGF-1
January 26, 2022
A new meta-analysis from Aging Cell has shown that both high and low levels of IGF-1 are related to mortality risk [1]. Insulin-like growth factor 1 (IGF-1) IGF-1 is one
Cellular Reprogramming Rejuvenates Multiple Organs in Mice
January 25, 2022
In a preprint showcased in bioRxiv, scientists have shown that a single cycle of partial cellular reprogramming can reverse multiple age-related changes in mice. Starting from a blank slate As
A Current Overview of Rejuvenation Techniques
January 24, 2022
Vadim Gladyshev and his team have published a review in Aging Cell about the current techniques and innovations in rejuvenation biotechnology, providing an overview of how these researchers see the
Objecting to Rejuvenation is Objecting to Medicine
January 24, 2022
Some people are uneasy about the idea of extending human healthy lifespan by using rejuvenation technologies that target the aging process directly. Even people who accept the possibility that such
Telomerase Alleviates Alzheimer’s Symptoms not via Telomeres
January 21, 2022
Scientists publishing in Nature Aging have shown that telomerase reverse transcriptase slows neurodegeneration but not due to its telomere-building activity [1]. Chromosomes’ bodyguards The word “telomerase” rings a huge bell
Journal Club January 2022 – CAR T cells produced in vivo to treat cardiac injury
January 21, 2022
Hosted by Dr. Oliver Medvedik, Journal Club returns on Tuesday 25th January at 12:00 Eastern and will be broadcast live on the Lifespan.io Facebook page. The topic for this month
CAR T Cells Produced in Vivo to Treat Cardiac Injury
January 21, 2022
Hosted by Dr. Oliver Medvedik, Journal Club returns on Tuesday 25th January at 12:00 Eastern and will be broadcast live on the Lifespan.io Facebook page. The topic for this month
An Open Access Research Tool for Lifespan Comparisons
January 21, 2022
Dr. Leon Peshkin talks us through a new open access research tool he has helped to develop. The Animal Life Expectancy Comparisons Research Tool (ALEC) is free for researchers to use
Heat Shock Protein Fights Senescence in Macular Degeneration
January 20, 2022
Researchers publishing in Experimental Eye Research have discovered that the peptide aB-crystallin can reduce the cellular senescence that affects the progression of age-related macular degeneration (AMD). What is αB-crystallin? αB-crystallin
Altos Labs’ $3 Billion Launch to Reverse Cellular Aging
January 20, 2022
In September 2021, we reported that Altos Labs was about to launch an ambitious project to develop partial cellular reprogramming to the point where it could be safely used in
Targeting Metabolism To Slow Down Aging
January 31, 2022
Publishing in Aging, a group of Korean researchers has discovered a compound that affects the way our mitochondria process energy, ameliorating cellular senescence. A deep dive into biochemistry To begin their paper, the researchers discuss the role of the SASP, the inflammatory cytokine IL-33, and the
Sonia Arrison: “Aging Is One of the Last Unifying Issues”
January 31, 2022
Sonia Arrison is an entrepreneur, investor, and best-selling author. Her book “100 Plus: How the Coming Age of Longevity Will Change Everything”, published in 2011, was one of the first to bring the topic of longevity to the general public’s attention. Sonia is also founder of
A New Startup Is Going After Rogue Cells
January 28, 2022
In a blog post, the founder and CEO of Arda Therapeutics, Adam Freund, explained his company’s intriguing strategy along with why it is imperative to counter aging. From Calico to Arda It’s not every day that the longevity field sees a new player with a fresh
Senolytics Restore Cognitive Ability in Aged Rats
January 27, 2022
Polish researchers publishing in Aging have discovered that the well-known senolytic combination of dasatinib and quercetin improves the cognitive capabilities of older rats. Understanding neuroplasticity While new neurons can be formed in the adult hippocampus through neurogenesis [1], learning and behavioral changes caused by changes in
Dietary Fiber and Probiotics Affect Melanoma Immunotherapy
January 26, 2022
A study published in Science by Dr. Jennifer A. Wargo and her colleagues spanning multiple centers recently examined if dietary fiber and commercially available probiotics affect immunotherapy response in cancer patients [1]. They hypothesized that bacteria from two probiotic species would be associated with a response
Meta-Analysis Discovers Goldilocks Zone for IGF-1
January 26, 2022
A new meta-analysis from Aging Cell has shown that both high and low levels of IGF-1 are related to mortality risk [1]. Insulin-like growth factor 1 (IGF-1) IGF-1 is one of the body’s major metabolic hormones. It can have effects similar to insulin, and it mediates
Cellular Reprogramming Rejuvenates Multiple Organs in Mice
January 25, 2022
In a preprint showcased in bioRxiv, scientists have shown that a single cycle of partial cellular reprogramming can reverse multiple age-related changes in mice. Starting from a blank slate As was first shown in 2006 by a group led by Shinya Yamanaka, introduction of four transcription
A Current Overview of Rejuvenation Techniques
January 24, 2022
Vadim Gladyshev and his team have published a review in Aging Cell about the current techniques and innovations in rejuvenation biotechnology, providing an overview of how these researchers see the state of the field. The reversibility of aging The reviewers begin by discussing the connection between
Objecting to Rejuvenation is Objecting to Medicine
January 24, 2022
Some people are uneasy about the idea of extending human healthy lifespan by using rejuvenation technologies that target the aging process directly. Even people who accept the possibility that such therapies can be developed are not always convinced that developing them is a good idea. Interestingly
Telomerase Alleviates Alzheimer’s Symptoms not via Telomeres
January 21, 2022
Scientists publishing in Nature Aging have shown that telomerase reverse transcriptase slows neurodegeneration but not due to its telomere-building activity [1]. Chromosomes’ bodyguards The word “telomerase” rings a huge bell for people who are familiar with geroscience. The primary function of this ribonucleoprotein complex (it consists
Journal Club January 2022 – CAR T cells produced in vivo to treat cardiac injury
January 21, 2022
Hosted by Dr. Oliver Medvedik, Journal Club returns on Tuesday 25th January at 12:00 Eastern and will be broadcast live on the Lifespan.io Facebook page. The topic for this month is the paper ‘CAR T cells produced in vivo to treat cardiac injury‘ which looks at
CAR T Cells Produced in Vivo to Treat Cardiac Injury
January 21, 2022
Hosted by Dr. Oliver Medvedik, Journal Club returns on Tuesday 25th January at 12:00 Eastern and will be broadcast live on the Lifespan.io Facebook page. The topic for this month is the paper ‘CAR T cells produced in vivo to treat cardiac injury‘, which looks at
An Open Access Research Tool for Lifespan Comparisons
January 21, 2022
Dr. Leon Peshkin talks us through a new open access research tool he has helped to develop. The Animal Life Expectancy Comparisons Research Tool (ALEC) is free for researchers to use now. If a drug increases lifespan in mice by 15%, should I take it? The idea
Heat Shock Protein Fights Senescence in Macular Degeneration
January 20, 2022
Researchers publishing in Experimental Eye Research have discovered that the peptide aB-crystallin can reduce the cellular senescence that affects the progression of age-related macular degeneration (AMD). What is αB-crystallin? αB-crystallin is a well-known heat shock protein, a family of proteins that is used in temperature regulation.
Altos Labs’ $3 Billion Launch to Reverse Cellular Aging
January 20, 2022
In September 2021, we reported that Altos Labs was about to launch an ambitious project to develop partial cellular reprogramming to the point where it could be safely used in humans to reverse cellular aging. That launch has now officially started, and Altos Labs is shaping