Category: Biology of Aging
Engineered Stem Cells Reduce Lung Fibrosis in Mice
July 17, 2025
In Molecular Therapy, researchers have described their creation of cells that express the regenerative factor GDF11 and found that they ameliorate fibrosis in a mouse model. Context-dependent benefits Like sirtuins
A Hallucinogenic Mushroom Compound Extends Mouse Lifespan
July 16, 2025
Researchers investigated psilocybin, a psychedelic compound found in hallucinogenic mushrooms, for its anti-aging properties. They found that it extends cellular and organismal lifespan, even when administered later in life [1].
Non-Toxic Stem Cell Transplantation Prevents Cancer in Mice
July 15, 2025
Scientists have developed a protocol for hematopoietic stem cell transplantation that reconstructs a healthy blood system and prevents blood cancers in old mice while also reducing toxicity [1]. The blood
How Blood-Brain Barrier Leaks Make Parkinson’s Worse
July 14, 2025
Researchers have discovered how α-synuclein (α-syn), a key protein in Parkinson’s disease and Lewy body dementia, leads to inflammation and disruption of the axons in the brain. Failure of the
Scientists Successfully Edit Mitochondrial DNA
July 11, 2025
A new study demonstrates that novel gene-editing tools can correct disease-causing mutations in mitochondrial DNA in primary human cells [1]. Smaller editing tools needed Genome-editing tools such as CRISPR were
Senolytics May Affect Inflammation-Related Cognitive Decline
July 10, 2025
Researchers have found that inflamed, senescent microglia prune too many synapses in the hippocampus and demonstrated that a senolytic compound can ameliorate this process in Aging Cell. Some synapse pruning
Molecular Similarities Between Cigarette Smoking and Aging
July 9, 2025
Researchers have analyzed molecular patterns from different tissues obtained from over 700 people and learned that smoking acts as an aging accelerator and involves molecular changes in tissues beyond those
Inflammaging Might Not Be Universal Across Populations
July 8, 2025
By comparing data from industrialized and non-industrialized societies, a new study calls into question some assumptions about the relationship between inflammation and aging [1]. Harmful protection Inflammation accompanies us throughout
Five Hallmarks of Stem Cell Aging Proposed
July 8, 2025
In Cell Stem Cell, a trio of reviewers has proposed five hallmarks that are specific to the aging of stem cells. Functional rather than molecular This review begins with a
Fixing Sugar Metabolism Shows Promise Against Dementia
July 4, 2025
Scientists have shown that aberrant metabolism of glycogen in neurons is linked to the accumulation of harmful tau protein. Caloric restriction, genetic interventions, and small molecules might help [1]. Glycogen
Researchers Connect Cellular Markers to Physical Well-Being
July 3, 2025
In Aging Cell, a team of researchers has described how the health of skin fibroblasts relates to physical and functional ability. Frailty, capacity, and skin cells This paper begins with
Healthspan Effects of an Anti-Aging Vaccine on Mice
July 2, 2025
The researchers of a recent study published in Aging Cell described their novel CD38 peptide vaccine, which improved many measurements of physical health and prevented cognitive decline in aged mice
Study Discovers a Mammalian Mechanism of Tissue Regeneration
July 2, 2025
Scientists have analyzed the differences between mammalian species that can regrow ear tissue after injury and those that cannot. Their findings can pave the way for novel regenerative therapies [1].
Researchers Identify a New Dementia Target
June 30, 2025
Researchers have ascertained that excessive amounts of complement C3, an essential immune protein that increases with aging, are responsible for causing dementia in a mouse model. A necessary complement The
Subcutaneous and Visceral Fat React Differently to Obesity
June 27, 2025
Scientists have found that visceral fat and subcutaneous fat produce different responses to obesity in male mice and human patients and identified an important regulator of these processes [1]. The
Engineered Stem Cells Reduce Lung Fibrosis in Mice
July 17, 2025
In Molecular Therapy, researchers have described their creation of cells that express the regenerative factor GDF11 and found that they ameliorate fibrosis in a mouse model. Context-dependent benefits Like sirtuins and klotho, GDF11 is a biochemical factor that has been heavily investigated in the context of
A Hallucinogenic Mushroom Compound Extends Mouse Lifespan
July 16, 2025
Researchers investigated psilocybin, a psychedelic compound found in hallucinogenic mushrooms, for its anti-aging properties. They found that it extends cellular and organismal lifespan, even when administered later in life [1]. From ancient times to contemporary therapies Hallucinogenic mushrooms have a long history of use, reaching back
Non-Toxic Stem Cell Transplantation Prevents Cancer in Mice
July 15, 2025
Scientists have developed a protocol for hematopoietic stem cell transplantation that reconstructs a healthy blood system and prevents blood cancers in old mice while also reducing toxicity [1]. The blood factory Hematopoietic stem cells (HSCs) work hard for our entire lives, producing vast numbers of various
How Blood-Brain Barrier Leaks Make Parkinson’s Worse
July 14, 2025
Researchers have discovered how α-synuclein (α-syn), a key protein in Parkinson’s disease and Lewy body dementia, leads to inflammation and disruption of the axons in the brain. Failure of the barrier Unlike other organs, the brain is heavily protected from many compounds in the bloodstream in
Scientists Successfully Edit Mitochondrial DNA
July 11, 2025
A new study demonstrates that novel gene-editing tools can correct disease-causing mutations in mitochondrial DNA in primary human cells [1]. Smaller editing tools needed Genome-editing tools such as CRISPR were one of the greatest scientific breakthroughs of this century. However, they are only good for editing
Senolytics May Affect Inflammation-Related Cognitive Decline
July 10, 2025
Researchers have found that inflamed, senescent microglia prune too many synapses in the hippocampus and demonstrated that a senolytic compound can ameliorate this process in Aging Cell. Some synapse pruning is normal During brain development, the resident immune cells of the brain (microglia) prune unneeded synapses
Molecular Similarities Between Cigarette Smoking and Aging
July 9, 2025
Researchers have analyzed molecular patterns from different tissues obtained from over 700 people and learned that smoking acts as an aging accelerator and involves molecular changes in tissues beyond those directly exposed to cigarette smoke [1]. Millions of preventable deaths Despite campaigns aimed at the reduction
Inflammaging Might Not Be Universal Across Populations
July 8, 2025
By comparing data from industrialized and non-industrialized societies, a new study calls into question some assumptions about the relationship between inflammation and aging [1]. Harmful protection Inflammation accompanies us throughout our entire lives. Without it, we would not be able to fight off pathogens. Yet, inflammation
Five Hallmarks of Stem Cell Aging Proposed
July 8, 2025
In Cell Stem Cell, a trio of reviewers has proposed five hallmarks that are specific to the aging of stem cells. Functional rather than molecular This review begins with a note that its classifications focus on the physical features and overall behavior rather than what is
Fixing Sugar Metabolism Shows Promise Against Dementia
July 4, 2025
Scientists have shown that aberrant metabolism of glycogen in neurons is linked to the accumulation of harmful tau protein. Caloric restriction, genetic interventions, and small molecules might help [1]. Glycogen and the brain Aberrant aggregation of microtubule-associated protein tau (MAPT), or simply tau protein, is a
Researchers Connect Cellular Markers to Physical Well-Being
July 3, 2025
In Aging Cell, a team of researchers has described how the health of skin fibroblasts relates to physical and functional ability. Frailty, capacity, and skin cells This paper begins with an explanation of how frailty and capacity are defined. The World Health Organization defines it as
Healthspan Effects of an Anti-Aging Vaccine on Mice
July 2, 2025
The researchers of a recent study published in Aging Cell described their novel CD38 peptide vaccine, which improved many measurements of physical health and prevented cognitive decline in aged mice [1]. A long-term anti-aging vaccine Many anti-aging strategies, such as supplementation, require regular, daily intake. A
Study Discovers a Mammalian Mechanism of Tissue Regeneration
July 2, 2025
Scientists have analyzed the differences between mammalian species that can regrow ear tissue after injury and those that cannot. Their findings can pave the way for novel regenerative therapies [1]. The lost art of regeneration Many animal species have amazing regenerative abilities. On the one side
Researchers Identify a New Dementia Target
June 30, 2025
Researchers have ascertained that excessive amounts of complement C3, an essential immune protein that increases with aging, are responsible for causing dementia in a mouse model. A necessary complement The complement system is a key immune system component that is involved in removing misfolded proteins, infectious
Subcutaneous and Visceral Fat React Differently to Obesity
June 27, 2025
Scientists have found that visceral fat and subcutaneous fat produce different responses to obesity in male mice and human patients and identified an important regulator of these processes [1]. The tale of the two fats It has been known that visceral fat, which accumulates around organs