Category: Biology of Aging
Inhibiting a Fundamental Factor in Brain Inflammation
January 30, 2025
Researchers have devised a method of reducing brain inflammation by creating a long-lasting inhibitor of the inflammatory factor NF-κB. Targeting inflammaging at its roots This study, published in the Nature
Ultrasound as a Tool to Eliminate Senescent Cells
January 29, 2025
A new study suggests that low-intensity pulsed ultrasound (LIPUS) can be beneficial in eliminating senescent cells through the recruitment and activation of immune cells [1]. The double-edged sword of the
Restoring Cellular Proliferation Through Exosomes
January 27, 2025
In Cell Metabolism, researchers have described how a microRNA (miRNA) derived from exosomes generated by human embryonic stem cells (hESCs) restores function and fights senescence in cell cultures and mice.
New Drug Eliminates Breast Cancer in Mouse Study
January 24, 2025
Researchers have discovered a small molecule that effectively kills cancer cells in the most prevalent type of breast cancer. The new drug could help against cancer recurrence and decrease the
Maintaining Muscle by Restoring Gut Bacteria
January 23, 2025
In Aging Cell, researchers have described how different combinations of gut bacteria impact muscle strength in mice. Expanding upon a known link The link between gut bacteria and health is
Maintaining Telomeres Extends Lifespan in Mice
January 22, 2025
A recent study has found that the overexpression of telomerase reverse transcriptase (TERT), which is a subunit of telomerase, an enzyme essential for telomere maintenance, leads to lifespan extension in
Fighting Alzheimer’s by Helping Neurons Consume Proteins
January 21, 2025
Researchers have found that kinesin family member 9 (KIF9), a protein that diminishes with aging, is instrumental in allowing cells to consume harmful proteins and fights Alzheimer’s in a mouse
New Study Links Epigenetic Changes to Genetic Mutations
January 21, 2025
A new paper published in Nature Aging suggests that somatic mutations cause significant remodeling of the epigenetic landscape. The findings might be relevant to future anti-aging interventions [1]. The genome
Enhancing NAD+ Efficiency by Energizing Sirtuins
January 16, 2025
Researchers publishing in Physical Review X have discovered compounds that can double the efficiency of the sirtuin SIRT3 in processing NAD+. Looking for a new way to boost enzymes The
The Impact of a Human Breast Milk Probiotic on Sarcopenia
January 15, 2025
A recent study linked probiotic-induced gut microbiome and metabolite changes to improved muscle functioning in older sarcopenia patients [1]. Sarcopenia and the gut Sarcopenia is an age-related condition. People with
Cyclarity Launches Human Trial for Atherosclerosis
January 13, 2025
Cyclarity Therapeutics, a biotechnology company based at the Buck Institute in California, has launched its first human clinical trial. Its primary candidate cyclodextrin drug, UDP-003, focuses on 7-ketocholesterol, an oxidized
Intermittent Fasting Improves Coordination in Mice
January 13, 2025
Researchers have discovered that intermittent fasting increases myelin in aged mice, leading to better neural function and coordination. Crucial proteins and a well-known intervention Normally, neuronal axons are coated in
Precision Targeting of Senescent Cells
January 9, 2025
In a journal called Small, researchers have described a new targeting mechanism for delivering senolytic compounds where they need to go. Finding the right nanoparticle This paper begins with a
Receiving Caloric Restriction Benefits Without Practicing It
January 8, 2025
In a new study, researchers have found that lithocholic acid, a metabolite found in the serum of calorically restricted mice, can mimic the effects of caloric restriction [1]. Restricting calories
Drinking and Dying: Alcohol as a Risk Factor for Cancer
January 7, 2025
A new advisory by the US Surgeon General highlights a topic that – as the document itself notes – has been flying mostly under the public’s radar: the relationship between
Inhibiting a Fundamental Factor in Brain Inflammation
January 30, 2025
Researchers have devised a method of reducing brain inflammation by creating a long-lasting inhibitor of the inflammatory factor NF-κB. Targeting inflammaging at its roots This study, published in the Nature journal Experimental & Molecular Medicine, begins with a discussion of age-related chronic inflammation (inflammaging) and its
Ultrasound as a Tool to Eliminate Senescent Cells
January 29, 2025
A new study suggests that low-intensity pulsed ultrasound (LIPUS) can be beneficial in eliminating senescent cells through the recruitment and activation of immune cells [1]. The double-edged sword of the SASP One of the characteristics of an aging organism is the accumulation of senescent cells. Various
Restoring Cellular Proliferation Through Exosomes
January 27, 2025
In Cell Metabolism, researchers have described how a microRNA (miRNA) derived from exosomes generated by human embryonic stem cells (hESCs) restores function and fights senescence in cell cultures and mice. Looking for a better senomorphic This study begins with a discussion of cellular senescence and its
New Drug Eliminates Breast Cancer in Mouse Study
January 24, 2025
Researchers have discovered a small molecule that effectively kills cancer cells in the most prevalent type of breast cancer. The new drug could help against cancer recurrence and decrease the need for surgery [1]. The ongoing fight against breast cancer Medicine has made great strides in
Maintaining Muscle by Restoring Gut Bacteria
January 23, 2025
In Aging Cell, researchers have described how different combinations of gut bacteria impact muscle strength in mice. Expanding upon a known link The link between gut bacteria and health is well-documented, and multiple biomarkers have confirmed that a healthy gut leads to health elsewhere [1]. This
Maintaining Telomeres Extends Lifespan in Mice
January 22, 2025
A recent study has found that the overexpression of telomerase reverse transcriptase (TERT), which is a subunit of telomerase, an enzyme essential for telomere maintenance, leads to lifespan extension in mice without significant side effects [1]. Protecting DNA Telomere shortening is a well-known hallmark of aging.
Fighting Alzheimer’s by Helping Neurons Consume Proteins
January 21, 2025
Researchers have found that kinesin family member 9 (KIF9), a protein that diminishes with aging, is instrumental in allowing cells to consume harmful proteins and fights Alzheimer’s in a mouse model. Consuming amyloids before they become a problem Alzheimer’s is well-known as a proteostasis disease: it
New Study Links Epigenetic Changes to Genetic Mutations
January 21, 2025
A new paper published in Nature Aging suggests that somatic mutations cause significant remodeling of the epigenetic landscape. The findings might be relevant to future anti-aging interventions [1]. The genome and the epigenome Genomic instability and epigenetic alterations are two of the hallmarks of aging [2].
Enhancing NAD+ Efficiency by Energizing Sirtuins
January 16, 2025
Researchers publishing in Physical Review X have discovered compounds that can double the efficiency of the sirtuin SIRT3 in processing NAD+. Looking for a new way to boost enzymes The researchers begin their paper by noting that most drugs administered to people are geared towards inhibition
The Impact of a Human Breast Milk Probiotic on Sarcopenia
January 15, 2025
A recent study linked probiotic-induced gut microbiome and metabolite changes to improved muscle functioning in older sarcopenia patients [1]. Sarcopenia and the gut Sarcopenia is an age-related condition. People with sarcopenia suffer from a reduction in muscle mass, strength, and function, leading to a decreased quality
Cyclarity Launches Human Trial for Atherosclerosis
January 13, 2025
Cyclarity Therapeutics, a biotechnology company based at the Buck Institute in California, has launched its first human clinical trial. Its primary candidate cyclodextrin drug, UDP-003, focuses on 7-ketocholesterol, an oxidized cholesterol variant that builds up in cells as we age. Atherosclerosis involves the accumulation of plaque
Intermittent Fasting Improves Coordination in Mice
January 13, 2025
Researchers have discovered that intermittent fasting increases myelin in aged mice, leading to better neural function and coordination. Crucial proteins and a well-known intervention Normally, neuronal axons are coated in a protein sheath made of myelin, which is necessary for their proper function [1]. Myelination is
Precision Targeting of Senescent Cells
January 9, 2025
In a journal called Small, researchers have described a new targeting mechanism for delivering senolytic compounds where they need to go. Finding the right nanoparticle This paper begins with a discussion of the well-known features of cellular senescence and laments that, despite all the work done
Receiving Caloric Restriction Benefits Without Practicing It
January 8, 2025
In a new study, researchers have found that lithocholic acid, a metabolite found in the serum of calorically restricted mice, can mimic the effects of caloric restriction [1]. Restricting calories to live longer Caloric restriction without malnutrition improves healthspan and extended lifespan in multiple model organisms
Drinking and Dying: Alcohol as a Risk Factor for Cancer
January 7, 2025
A new advisory by the US Surgeon General highlights a topic that – as the document itself notes – has been flying mostly under the public’s radar: the relationship between alcohol consumption and cancer. While most people are aware of smoking and obesity being risk factors