Category: Biology of Aging
Very Old People Have Healthy Gut Bacteria
July 31, 2024
The authors of a recent review investigated what is known about gut microbiota in centenarians and how gut microbes can help people achieve extreme longevity [1]. What makes centenarians special?
A Key Pathway for Sarcopenia Reversal
July 30, 2024
In Aging Cell, researchers have published a paper on a cellular energy source that appears to be a key signaling molecule in sarcopenia. A little-explored molecule Sarcopenia, a condition that
Senescence May Play a Significant Role in Parkinson’s
July 29, 2024
In Aging, a pair of researchers has published a perspective connecting fat (lipid) accumulation and cellular senescence in neurons to Parkinson’s disease. α-syn, but not just α-syn Parkinson’s disease is
Surprising Effects of Regular Fasting in Model Organisms
July 28, 2024
Research published in Aging Cell has revealed that a nematode species commonly used for aging research lives much longer on an alternate-day fasting regimen, but only when it is administered
Cellular Reprogramming Improves Cognition in Aged Rats
July 26, 2024
Scientists have shown that prolonged, continuous expression of reprogramming factors counters cognitive decline in old rats and probably decreases their epigenetic age [1]. Reprogramming and cognitive function Cellular reprogramming, the
Exploring Senescence in Tendon Function
July 25, 2024
In Aging Cell, researchers have published new data on the relationship between senescence and the extracellular matrix in the tendons of older people. Easy to injure, hard to heal The
Antinuclear Antibody Shows Promise Against Cancer
July 23, 2024
Scientists have developed a conjugate of a drug and a nucleus-targeting antibody that can attack multiple types of cancer cells without targeting a particular antigen [1]. The anti-nuclear missile Antinuclear
Exploring How Stiffness Promotes Osteoarthritis
July 22, 2024
In iScience, researchers have explained how physical mechanics can alter mitochondrial function in a way that leads to osteoarthritis. When simple physics affects biology Previous work has pinpointed abnormal mechanical
Late-Life Treatment Increases Mouse Lifespan by 25%
July 19, 2024
A new mouse study has found that both germline knockout and late-life inhibition of the pro-inflammatory cytokine IL-11 lead to comparable and powerful healthspan and lifespan extension [1]. The inflammatory
Discovering Why an Inflammatory Compound Inhibits Cancer
July 18, 2024
In Aging Cell, researchers have published their findings into why the inflammatory factor IL-6 inhibits cancerous tumors when generated inside the cell. IL-6 affects both senescence and cancer proliferation One
Probiotics Have Positive Cognitive Effects in Trial
July 17, 2024
A clinical trial has found that consuming a multi-species probiotic formulation positively impacts mental well-being and improves cognitive functions [1]. Gut-brain crosstalk The gut microbiome is a gathering of microorganisms
Mixed Results in Probiotic Trial Against Inflammaging
July 15, 2024
Researchers publishing in Probiotics and Antimicrobial Proteins have published the results of a clinical trial on the effects of a probiotic on inflammaging in older people. The gut and systemic
Modified Natural Killer Cells Effective Against Liver Cancer
July 12, 2024
By making NK cells insensitive to tumor-secreted TGF-β, scientists have improved their efficacy against this deadly hepatocellular carcinoma (HCC) [1]. Liver cancer and TGF-β Cancer cells, which are supposed to
Sex Differences in the Blood-Brain Barrier and Alzheimer’s
July 11, 2024
Researchers have found that men and women have significant differences in how their brains’ blood vessels change in Alzheimer’s disease. The collapse of the blood-brain barrier This research begins with
Precision Nutrition Improves Life Quality for Older People
July 10, 2024
Researchers compared general nutritional advice to individualized nutritional advice in addition to an app that encourages its users to follow a diet. Elderly overweight and obese people benefited more from
Very Old People Have Healthy Gut Bacteria
July 31, 2024
The authors of a recent review investigated what is known about gut microbiota in centenarians and how gut microbes can help people achieve extreme longevity [1]. What makes centenarians special? One way of investigating what gives people longevity and health in older ages is to study
A Key Pathway for Sarcopenia Reversal
July 30, 2024
In Aging Cell, researchers have published a paper on a cellular energy source that appears to be a key signaling molecule in sarcopenia. A little-explored molecule Sarcopenia, a condition that increases with aging, reduces muscle mass in older people, and leads to a decreased quality of
Senescence May Play a Significant Role in Parkinson’s
July 29, 2024
In Aging, a pair of researchers has published a perspective connecting fat (lipid) accumulation and cellular senescence in neurons to Parkinson’s disease. α-syn, but not just α-syn Parkinson’s disease is characterized by the loss of a specific population of neurons: the dopaminergic neurons in the substantia
Surprising Effects of Regular Fasting in Model Organisms
July 28, 2024
Research published in Aging Cell has revealed that a nematode species commonly used for aging research lives much longer on an alternate-day fasting regimen, but only when it is administered in middle age and only when the worms are consuming an animal-based protein source. Deciding what
Cellular Reprogramming Improves Cognition in Aged Rats
July 26, 2024
Scientists have shown that prolonged, continuous expression of reprogramming factors counters cognitive decline in old rats and probably decreases their epigenetic age [1]. Reprogramming and cognitive function Cellular reprogramming, the act of bringing differentiated cells back to a stem-like pluripotent state by expressing certain genes, has
Exploring Senescence in Tendon Function
July 25, 2024
In Aging Cell, researchers have published new data on the relationship between senescence and the extracellular matrix in the tendons of older people. Easy to injure, hard to heal The researchers begin this paper by pointing out that injuries to the musculoskeletal system are responsible for
Antinuclear Antibody Shows Promise Against Cancer
July 23, 2024
Scientists have developed a conjugate of a drug and a nucleus-targeting antibody that can attack multiple types of cancer cells without targeting a particular antigen [1]. The anti-nuclear missile Antinuclear antibodies (ANA) are usually associated with autoimmune diseases, such as lupus, where those antibodies attack cellular
Exploring How Stiffness Promotes Osteoarthritis
July 22, 2024
In iScience, researchers have explained how physical mechanics can alter mitochondrial function in a way that leads to osteoarthritis. When simple physics affects biology Previous work has pinpointed abnormal mechanical loading, which occurs when joints are placed under excessive stresses in ways that they were not
Late-Life Treatment Increases Mouse Lifespan by 25%
July 19, 2024
A new mouse study has found that both germline knockout and late-life inhibition of the pro-inflammatory cytokine IL-11 lead to comparable and powerful healthspan and lifespan extension [1]. The inflammatory message As part of inflammaging, the pro-inflammatory cytokines that act as messengers, transferring and amplifying inflammatory
Discovering Why an Inflammatory Compound Inhibits Cancer
July 18, 2024
In Aging Cell, researchers have published their findings into why the inflammatory factor IL-6 inhibits cancerous tumors when generated inside the cell. IL-6 affects both senescence and cancer proliferation One of the core parts of the SASP is the inflammatory cytokine interleukin 6 (IL-6). While this
Probiotics Have Positive Cognitive Effects in Trial
July 17, 2024
A clinical trial has found that consuming a multi-species probiotic formulation positively impacts mental well-being and improves cognitive functions [1]. Gut-brain crosstalk The gut microbiome is a gathering of microorganisms in the human gut that plays multiple essential functions, from nutrient absorption to immune system modulation
Mixed Results in Probiotic Trial Against Inflammaging
July 15, 2024
Researchers publishing in Probiotics and Antimicrobial Proteins have published the results of a clinical trial on the effects of a probiotic on inflammaging in older people. The gut and systemic inflammation The researchers begin this paper discussing their target of inflammaging, as this condition has been
Modified Natural Killer Cells Effective Against Liver Cancer
July 12, 2024
By making NK cells insensitive to tumor-secreted TGF-β, scientists have improved their efficacy against this deadly hepatocellular carcinoma (HCC) [1]. Liver cancer and TGF-β Cancer cells, which are supposed to be vulnerable to the immune system, develop various defensive mechanisms to avoid detection and decrease immune
Sex Differences in the Blood-Brain Barrier and Alzheimer’s
July 11, 2024
Researchers have found that men and women have significant differences in how their brains’ blood vessels change in Alzheimer’s disease. The collapse of the blood-brain barrier This research begins with a discussion of Alzheimer’s and its two principal symptoms: the well-known plaques that coat the brain,
Precision Nutrition Improves Life Quality for Older People
July 10, 2024
Researchers compared general nutritional advice to individualized nutritional advice in addition to an app that encourages its users to follow a diet. Elderly overweight and obese people benefited more from the individualized approach [1]. One size doesn’t fit all Proper diets can help people stay healthy