Category: Biology of Aging
More Social Connections Associated with Slower Aging
April 3, 2024
Recent research has contributed to the growing body of evidence regarding social isolation, loneliness, and biological aging [1]. Social isolation is not generally screened for During doctor visits, patients are
Longevity and DeSci Recap – March 2024
April 2, 2024
Welcome back for the latest edition of the Longevity and DeSci Recap. This March has seen a swarm of activity as the longevity and DeSci world has sprung to renewed
The Epigenetic Similarities Between E-Cigarettes and Smoking
April 1, 2024
The authors of a new paper in Cancer Research have published the surprising finding that cigarettes and e-cigarettes have some similar effects on DNA methylation that have been reported to
Nicklas Brendborg on How Jellyfish Age Backwards
April 1, 2024
The quest for eternal youth, encapsulated in Dr. Malcolm’s fictional yet profound declaration that “Life finds a way,” mirrors humanity’s age-old fascination with longevity. This fascination isn’t new; as Nicolas
Restoring Lymphoid-Myeloid Balance Boosts Immunity in Mice
March 29, 2024
A new study suggests that depleting a subset of stem cells that overproduces myeloid cells can rescue age-related immunosenescence [1]. Thrown off balance Immunosenescence, the gradual decline in the immune
Popular Antioxidants Don’t Work Against Bone Loss in Mice
March 28, 2024
In Aging, researchers have published negative results on the long-term use of methylene blue and mitoquinone (MitoQ), two popular antioxidants, to sustain bone health in mice. Oxidative stress and bone
Natural Senotherapeutics that Mimic Dasatinib
March 27, 2024
Scientific Reports has published a study that used a computational approach to identify natural senotherapeutics that have a similar impact on gene expression as a known senotherapeutic drug, dasatinib [1].
First Transplantation of a Pig Kidney into a Human
March 26, 2024
After a total of 69 rejection-preventing gene edits, history has been made with the first-ever successful transplantation of a pig kidney into a human patient. Xenotransplantation within reach Organ transplantation
An Experimental Brain Protector May Fight Obesity
March 25, 2024
According to a paper published in Aging, a fisetin derivative that is being investigated for brain protection may also be effective in controlling glucose and ameliorating obesity. Repurposing a repurposed
Glial Cells and Neurons Mutate Differently
March 24, 2024
In Cell, researchers have published a paper outlining the different ways in which brain cells slowly mutate with aging. The genomic damage of aging Cells accumulate mutations with aging, including
Epigenetic Memory Might Underlie Multiple Sclerosis
March 21, 2024
In an in-depth paper in Nature, researchers have explained how astrocytes, helper cells that provide crucial brain functions, epigenetically remember things in a way that encourages inflammation. Traumatized cells Long-lived
Caloric Restriction in Primates Leads to Gut Changes
March 20, 2024
In a recent Nature Communications paper, the researchers investigated changes in weight, metabolism, and microbiome that resulted from periodic restricted feeding in non-human primates [1]. Continuous vs. time-restricted caloric restriction
A Small Molecule to Restore the Liver
March 18, 2024
In Cell, a team of researchers, including the founders of the biotech company HepaRegeniX, has published a paper on HRX215, a molecule that encourages liver regeneration. When the liver doesn’t
Senolytic Activity of Drug-Polyphenol Combinations
March 13, 2024
The authors of a paper published in Pharmaceuticals tested multiple drug-polyphenol combinations to find the ones with the best senolytic properties [1]. Targeting senescent cells in lung diseases Various drugs
Reprogramming Cells to Research Aging
March 11, 2024
Instead of using cellular reprogramming to directly treat age-related diseases, a perspective published in Nature Communications focuses on the opposite: using reprogrammed cells to form aged tissues and organoids on
More Social Connections Associated with Slower Aging
April 3, 2024
Recent research has contributed to the growing body of evidence regarding social isolation, loneliness, and biological aging [1]. Social isolation is not generally screened for During doctor visits, patients are often screened for many physical conditions. However, screening for social isolation in the clinic is not
Longevity and DeSci Recap – March 2024
April 2, 2024
Welcome back for the latest edition of the Longevity and DeSci Recap. This March has seen a swarm of activity as the longevity and DeSci world has sprung to renewed life. Between the many upcoming conferences, latest investment news, and innovations happening at the Vitalia pop-up
The Epigenetic Similarities Between E-Cigarettes and Smoking
April 1, 2024
The authors of a new paper in Cancer Research have published the surprising finding that cigarettes and e-cigarettes have some similar effects on DNA methylation that have been reported to lead to cancer. Harm reduction might not truly reduce harm It is well-known that cigarettes are
Nicklas Brendborg on How Jellyfish Age Backwards
April 1, 2024
The quest for eternal youth, encapsulated in Dr. Malcolm’s fictional yet profound declaration that “Life finds a way,” mirrors humanity’s age-old fascination with longevity. This fascination isn’t new; as Nicolas Brendborg’s “Jellyfish Age Backwards – Nature’s Secrets to Longevity” expounds; it’s as ancient as the epic
Restoring Lymphoid-Myeloid Balance Boosts Immunity in Mice
March 29, 2024
A new study suggests that depleting a subset of stem cells that overproduces myeloid cells can rescue age-related immunosenescence [1]. Thrown off balance Immunosenescence, the gradual decline in the immune system’s abilities, is one of the hallmarks of aging [2]. Moreover, many scientists view it as
Popular Antioxidants Don’t Work Against Bone Loss in Mice
March 28, 2024
In Aging, researchers have published negative results on the long-term use of methylene blue and mitoquinone (MitoQ), two popular antioxidants, to sustain bone health in mice. Oxidative stress and bone health Previous work has found that oxidative stress, which is commonly associated with age-related disease and
Natural Senotherapeutics that Mimic Dasatinib
March 27, 2024
Scientific Reports has published a study that used a computational approach to identify natural senotherapeutics that have a similar impact on gene expression as a known senotherapeutic drug, dasatinib [1]. Drug combinations for better treatments Cellular senescence, a state in which cells cannot divide anymore but
First Transplantation of a Pig Kidney into a Human
March 26, 2024
After a total of 69 rejection-preventing gene edits, history has been made with the first-ever successful transplantation of a pig kidney into a human patient. Xenotransplantation within reach Organ transplantation has been one of modern medicine’s biggest triumphs, helping to save innumerable lives. It is also
An Experimental Brain Protector May Fight Obesity
March 25, 2024
According to a paper published in Aging, a fisetin derivative that is being investigated for brain protection may also be effective in controlling glucose and ameliorating obesity. Repurposing a repurposed compound CMS121, the focus of this study, was created by modifying fisetin, a flavonol that is
Glial Cells and Neurons Mutate Differently
March 24, 2024
In Cell, researchers have published a paper outlining the different ways in which brain cells slowly mutate with aging. The genomic damage of aging Cells accumulate mutations with aging, including brain cells [1]. However, as these researchers note, most previous research into these mutations has been
Epigenetic Memory Might Underlie Multiple Sclerosis
March 21, 2024
In an in-depth paper in Nature, researchers have explained how astrocytes, helper cells that provide crucial brain functions, epigenetically remember things in a way that encourages inflammation. Traumatized cells Long-lived immune cells, including T cells and B cells, can remember foreign pathogens [1]. This is why
Caloric Restriction in Primates Leads to Gut Changes
March 20, 2024
In a recent Nature Communications paper, the researchers investigated changes in weight, metabolism, and microbiome that resulted from periodic restricted feeding in non-human primates [1]. Continuous vs. time-restricted caloric restriction Caloric restriction, which limits the amount of calories an organism consumes, is a widely known lifespan-extending
A Small Molecule to Restore the Liver
March 18, 2024
In Cell, a team of researchers, including the founders of the biotech company HepaRegeniX, has published a paper on HRX215, a molecule that encourages liver regeneration. When the liver doesn’t regenerate The researchers note that the liver has a “nearly unlimited regenerative potential” under healthy circumstances.
Senolytic Activity of Drug-Polyphenol Combinations
March 13, 2024
The authors of a paper published in Pharmaceuticals tested multiple drug-polyphenol combinations to find the ones with the best senolytic properties [1]. Targeting senescent cells in lung diseases Various drugs are being used to address some of the problems associated with cellular senescence. For example, some
Reprogramming Cells to Research Aging
March 11, 2024
Instead of using cellular reprogramming to directly treat age-related diseases, a perspective published in Nature Communications focuses on the opposite: using reprogrammed cells to form aged tissues and organoids on which to conduct experiments. Why not just use donors? Obviously, there is no shortage of age-related