Category: Biology of Aging
Music Therapy for Treating Alzheimer’s Disease
November 29, 2023
The authors of a new review have analyzed randomized controlled trials that evaluated the impact of music therapy on the cognitive functions of people with Alzheimer’s [1]. Music to Alzheimer’s
Isoleucine Restriction Boosts Lifespan in Mice
November 28, 2023
A new study reports a massive 33% increase in median lifespan in male genetically heterogeneous mice following prolonged isoleucine restriction [1]. Not all calories are created equal Caloric restriction is
Mammals Accumulate Epigenetic Noise With Age
November 27, 2023
In Nature Communications, researchers have explained how epigenetic drift and disorder are associated with shorter lifespans across species. When randomness is a problem We have previously reported on research demonstrating
B12 Is a Limiting Factor for Induced Cellular Plasticity
November 27, 2023
Due to Thanksgiving happening on our usual timeslot, the Journal Club returns on December 1st at 12 Eastern. The show will be livestreamed on the lifespan.io Facebook channel and hosted
Journal Club Nov – B12 and Cell Plasticity
November 27, 2023
Due to Thanksgiving happening on our usual timeslot, the Journal Club returns on December 1st at 12 Eastern. The show will be livestreamed on the lifespan.io Facebook channel and hosted
Predicting a Species’ Longevity Through Epigenetics
November 26, 2023
A preprint study published on bioRxiv discusses how a species’ maximum lifespan can be predicted by its epigenetics, showing that these differences are largely unaffected by interventions. Differences and similarities
Aging Might Blunt the Effects of Fasting
November 24, 2023
Scientists have found that in killifish, old age is associated with a dampened response to fasting and identified the protein that might be responsible. A similar mechanism might exist in
Some HIV-Fighting Drugs May Also Fight Aging
November 23, 2023
Publishing in Ageing Research Reviews, a team of researchers including Vera Gorbunova has described how a class of drugs originally used to treat HIV might be used to affect some
Dual-Purpose Molecular Targets for Cancer and Aging
November 22, 2023
A new study published in Aging Cell applied an artificial intelligence target discovery platform to aid in identifying potential dual-purpose targets for anti-aging and anti-cancer treatments [1]. Killing two birds
Young People More Vulnerable to Atherosclerosis Risk Factors
November 21, 2023
A new study suggests that increases in LDL cholesterol and systolic blood pressure elevate the risk of atherosclerosis progression more in younger than in older people. The good news is
Skin Collagen Loss Makes It Easier For Cancer To Grow
November 20, 2023
A new paper published in Nature has described how the aging extracellular matrix makes it easier for cancer to grow. When cancer is skin deep Under normal circumstances, we lose
An Anonymous Longevity Enthusiast Unmasks Himself
November 20, 2023
A prolific anonymous poster who became popular in the longevity community has revealed his identity, and other longevity luminaries have chimed in. The anonym Anonymity is seldom practiced in the
Pushing Forward on Understanding Cellular Decline
November 19, 2023
Researchers publishing in Nature Aging have investigated one of the core biological reasons behind the decline of stem cells’ ability to proliferate. Heterochromatin and euchromatin The genetic component of cells
Senolytics May Work Against Long COVID in the Brain
November 16, 2023
A new publication in Nature Aging has used organoids and model mice to discover that senolytics may be effective treatments for neurodegeneration caused by long COVID. A link between COVID-19
Saposhnikovia Root Extract Improves Tendon Repair
November 14, 2023
A new study has identified a molecule found in Saposhnikovia root as a potent mediator of tendon regeneration in rats. The results were also replicated in human cells [1]. Aging
Music Therapy for Treating Alzheimer’s Disease
November 29, 2023
The authors of a new review have analyzed randomized controlled trials that evaluated the impact of music therapy on the cognitive functions of people with Alzheimer’s [1]. Music to Alzheimer’s patients’ ears Current pharmacology lacks a long-term method of effectively managing Alzheimer’s disease symptoms. Therefore, researchers
Isoleucine Restriction Boosts Lifespan in Mice
November 28, 2023
A new study reports a massive 33% increase in median lifespan in male genetically heterogeneous mice following prolonged isoleucine restriction [1]. Not all calories are created equal Caloric restriction is the most powerful life-extending intervention in rodents and primates [2], but the needed magnitude (about 30%
Mammals Accumulate Epigenetic Noise With Age
November 27, 2023
In Nature Communications, researchers have explained how epigenetic drift and disorder are associated with shorter lifespans across species. When randomness is a problem We have previously reported on research demonstrating that epigenetic clocks are most likely to be measuring noise. This paper builds on that concept,
B12 Is a Limiting Factor for Induced Cellular Plasticity
November 27, 2023
Due to Thanksgiving happening on our usual timeslot, the Journal Club returns on December 1st at 12 Eastern. The show will be livestreamed on the lifespan.io Facebook channel and hosted by Dr. Oliver Medvedik. This month, we will be taking a look at a new paper
Journal Club Nov – B12 and Cell Plasticity
November 27, 2023
Due to Thanksgiving happening on our usual timeslot, the Journal Club returns on December 1st at 12 Eastern. The show will be livestreamed on the lifespan.io Facebook channel and hosted by Dr. Oliver Medvedik. This month we will be taking a look at a new paper
Predicting a Species’ Longevity Through Epigenetics
November 26, 2023
A preprint study published on bioRxiv discusses how a species’ maximum lifespan can be predicted by its epigenetics, showing that these differences are largely unaffected by interventions. Differences and similarities in mammals The researchers begin their paper with a note that bowhead whales live over a
Aging Might Blunt the Effects of Fasting
November 24, 2023
Scientists have found that in killifish, old age is associated with a dampened response to fasting and identified the protein that might be responsible. A similar mechanism might exist in humans [1]. Fast less furious Various fasting regimens are thought to confer health and longevity benefits
Some HIV-Fighting Drugs May Also Fight Aging
November 23, 2023
Publishing in Ageing Research Reviews, a team of researchers including Vera Gorbunova has described how a class of drugs originally used to treat HIV might be used to affect some of the hallmarks of aging. Inhibiting DNA changes DNA transcription, which transfers DNA code into the
Dual-Purpose Molecular Targets for Cancer and Aging
November 22, 2023
A new study published in Aging Cell applied an artificial intelligence target discovery platform to aid in identifying potential dual-purpose targets for anti-aging and anti-cancer treatments [1]. Killing two birds with one stone Aging, as is the case with many diseases, is a risk factor for
Young People More Vulnerable to Atherosclerosis Risk Factors
November 21, 2023
A new study suggests that increases in LDL cholesterol and systolic blood pressure elevate the risk of atherosclerosis progression more in younger than in older people. The good news is that this can be reversed [1]. Creeping atherosclerosis Atherosclerosis is a major risk factor for cardiovascular
Skin Collagen Loss Makes It Easier For Cancer To Grow
November 20, 2023
A new paper published in Nature has described how the aging extracellular matrix makes it easier for cancer to grow. When cancer is skin deep Under normal circumstances, we lose and regain skin cells constantly. Old skin flakes away, and stem cells constantly divide and differentiate
An Anonymous Longevity Enthusiast Unmasks Himself
November 20, 2023
A prolific anonymous poster who became popular in the longevity community has revealed his identity, and other longevity luminaries have chimed in. The anonym Anonymity is seldom practiced in the longevity community. Everyone knows everyone, and on social media, most people use their real names rather
Pushing Forward on Understanding Cellular Decline
November 19, 2023
Researchers publishing in Nature Aging have investigated one of the core biological reasons behind the decline of stem cells’ ability to proliferate. Heterochromatin and euchromatin The genetic component of cells is comprised of two main parts: heterochromatin and euchromatin. Heterochromatin is largely silent, as it is
Senolytics May Work Against Long COVID in the Brain
November 16, 2023
A new publication in Nature Aging has used organoids and model mice to discover that senolytics may be effective treatments for neurodegeneration caused by long COVID. A link between COVID-19 and cellular senescence Post-acute infection syndromes (PAISes) are caused by a variety of viral and bacterial
Saposhnikovia Root Extract Improves Tendon Repair
November 14, 2023
A new study has identified a molecule found in Saposhnikovia root as a potent mediator of tendon regeneration in rats. The results were also replicated in human cells [1]. Aging does not spare tendons Like with many tissues, the health of tendons, which are central to