Category: Biology of Aging
Centenarians Have Slightly Different Gut Ecologies
May 29, 2023
Researchers publishing in Nature Microbiology have determined that the viruses populating the intestines of centenarians are slightly different from those of the merely old. Viruses for bacteria, not people We
Hypoxia Extends Median Lifespan in Fast-Aging Mice by 50%
May 26, 2023
Scientists have found that continuous oxygen restriction drastically extends the lifespan of progeroid mice, but the effect’s mechanism remains a mystery [1]. Can less oxygen be better? Hypoxia is a
Discovering Why Adrenal Cancer Is More Dangerous for Women
May 25, 2023
A paper published today in Nature Aging has explained a relationship between cellular senescence, cancer of the adrenal glands, and sex differences. A closer look at age-related cancer Over 90%
How Your Funding Has Helped Mitochondrial Research
May 24, 2023
Financed by lifespan.io’s crowdfunding efforts, SENS Research Foundation has engaged in fruitful research into ways of dealing with mitochondrial dysfunction, the gradual loss of function of our cells’ power plants.
A New Tool for Editing Mitochondrial DNA
May 22, 2023
Researchers publishing in Nature Biotechnology have developed a novel method of editing mitochondrial DNA, which cannot be accomplished with nuclear DNA tools. Where CRISPR doesn’t work While CRISPR is the
Rare Gene Variant Appears to Protect Against Alzheimer’s
May 19, 2023
Scientists studying people with autosomal dominant Alzheimer’s disease have found a genetic variant that is associated with decades of stalled onset [1]. The predictable Alzheimer’s Scientists still do not know
A Senolytic Drug May Already Be in the Clinic
May 18, 2023
Researchers publishing in Aging have investigated zoledronic acid, a drug already used to protect bones and fight osteoporosis, for its activity against cellular senescence. An approved drug with established effects
Targeting Age-Related Metabolic Shifts in the Brain
May 17, 2023
Publishing in Aging, a team of Chilean researchers has described a relationship between gene shifts in the brain and neurons not getting the energy they need. Greedy glia To perform
Building Artificial Organoids to Study Diseases
May 15, 2023
In an open-access paper published in Cell Stem Cell this month, researchers have explained how organoids derived from human pluripotent stem cells (hPSCs) are being used to analyze diseases and
Destroying ‘Zombie’ Cells for Cardiovascular Health
May 12, 2023
Researchers have demonstrated that two senolytic drugs might improve how the heart repairs itself by destroying senescent cells [1]. These harmful cells are associated with many age-related diseases, including cardiovascular
Protecting Mass-Produced Stem Cells from the Immune System
May 11, 2023
Researchers publishing in Nature Biotechnology have demonstrated a method of protecting mass-produced stem cells from the immune system, with strongly positive results in two different animal models. Fake ID for
Gene Therapy Ameliorates Sarcopenia in Old Mice
May 8, 2023
A paper published in Aging has detailed how gene therapy has been used to treat sarcopenia in wild-type mice, and the results are positive. A lack of effective treatments As
Flavonols, Especially Quercetin, Linked to Less Frailty
May 2, 2023
In a new prospective cohort study, a higher intake of flavonols, and quercetin in particular, was linked to a significant decrease in the risk of frailty [1]. Flavonoids: not just
Netrin-1 Rescues Blood Stem Cells in Mice
April 28, 2023
Scientists have discovered that the protein Netrin-1 alleviates the age-related decline in hematopoietic stem cell function in mice, enhancing HSC transplantation and protecting these mice from the harmful effects of
Hair Pigment Stem Cells May Work Differently
April 27, 2023
Researchers publishing in Nature have made the surprising discovery that pigmentation cells (melanocytes) can naturally transition back into the stem cell state in a process called dedifferentiation. A kinship with
Centenarians Have Slightly Different Gut Ecologies
May 29, 2023
Researchers publishing in Nature Microbiology have determined that the viruses populating the intestines of centenarians are slightly different from those of the merely old. Viruses for bacteria, not people We have written previously about a study showing that centenarians have youthful bacterial gut compositions (enterotypes) similar
Hypoxia Extends Median Lifespan in Fast-Aging Mice by 50%
May 26, 2023
Scientists have found that continuous oxygen restriction drastically extends the lifespan of progeroid mice, but the effect’s mechanism remains a mystery [1]. Can less oxygen be better? Hypoxia is a condition in which an organism or an organ in the body does not receive enough oxygen.
Discovering Why Adrenal Cancer Is More Dangerous for Women
May 25, 2023
A paper published today in Nature Aging has explained a relationship between cellular senescence, cancer of the adrenal glands, and sex differences. A closer look at age-related cancer Over 90% of cancer diagnoses are made in people over a half century old [1]. This is not
How Your Funding Has Helped Mitochondrial Research
May 24, 2023
Financed by lifespan.io’s crowdfunding efforts, SENS Research Foundation has engaged in fruitful research into ways of dealing with mitochondrial dysfunction, the gradual loss of function of our cells’ power plants. Here, the organization reports its successes in handling this aspect of aging. The cellular machinery and
A New Tool for Editing Mitochondrial DNA
May 22, 2023
Researchers publishing in Nature Biotechnology have developed a novel method of editing mitochondrial DNA, which cannot be accomplished with nuclear DNA tools. Where CRISPR doesn’t work While CRISPR is the established, go-to method for genetic modification in the nucleus, it doesn’t work in the mitochondria. CRISPR
Rare Gene Variant Appears to Protect Against Alzheimer’s
May 19, 2023
Scientists studying people with autosomal dominant Alzheimer’s disease have found a genetic variant that is associated with decades of stalled onset [1]. The predictable Alzheimer’s Scientists still do not know what causes most cases of Alzheimer’s, although certain genetic variants (most notably APOE4) have been shown
A Senolytic Drug May Already Be in the Clinic
May 18, 2023
Researchers publishing in Aging have investigated zoledronic acid, a drug already used to protect bones and fight osteoporosis, for its activity against cellular senescence. An approved drug with established effects Zoledronate has already been approved by the FDA for clinical use, as it has been prescribed
Targeting Age-Related Metabolic Shifts in the Brain
May 17, 2023
Publishing in Aging, a team of Chilean researchers has described a relationship between gene shifts in the brain and neurons not getting the energy they need. Greedy glia To perform various maintenance and protective tasks, the brain contains a large population of microglia alongside its neurons.
Building Artificial Organoids to Study Diseases
May 15, 2023
In an open-access paper published in Cell Stem Cell this month, researchers have explained how organoids derived from human pluripotent stem cells (hPSCs) are being used to analyze diseases and develop treatments. Different sources for different conditions This review includes both human embryonic stem cells (hESCs),
Destroying ‘Zombie’ Cells for Cardiovascular Health
May 12, 2023
Researchers have demonstrated that two senolytic drugs might improve how the heart repairs itself by destroying senescent cells [1]. These harmful cells are associated with many age-related diseases, including cardiovascular disease. Zombie cells that refuse to die As we age, our bodies accumulate senescent cells, often
Protecting Mass-Produced Stem Cells from the Immune System
May 11, 2023
Researchers publishing in Nature Biotechnology have demonstrated a method of protecting mass-produced stem cells from the immune system, with strongly positive results in two different animal models. Fake ID for the immune system While it would be ideal to create stem cells from each person’s existing
Gene Therapy Ameliorates Sarcopenia in Old Mice
May 8, 2023
A paper published in Aging has detailed how gene therapy has been used to treat sarcopenia in wild-type mice, and the results are positive. A lack of effective treatments As expected with papers of this kind, the researchers begin by discussing frailty and sarcopenia, the age-related
Flavonols, Especially Quercetin, Linked to Less Frailty
May 2, 2023
In a new prospective cohort study, a higher intake of flavonols, and quercetin in particular, was linked to a significant decrease in the risk of frailty [1]. Flavonoids: not just flavor Flavonoids are a class of polyphenolic compounds that include flavanols, flavonols, flavones, anthocyanins, and some
Netrin-1 Rescues Blood Stem Cells in Mice
April 28, 2023
Scientists have discovered that the protein Netrin-1 alleviates the age-related decline in hematopoietic stem cell function in mice, enhancing HSC transplantation and protecting these mice from the harmful effects of chemotherapy [1]. (Not) a niche problem Declining stem cell function (stem cell exhaustion) is linked to
Hair Pigment Stem Cells May Work Differently
April 27, 2023
Researchers publishing in Nature have made the surprising discovery that pigmentation cells (melanocytes) can naturally transition back into the stem cell state in a process called dedifferentiation. A kinship with hair follicle cells These researchers begin their study by discussing stem cells and their proliferation. In